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Genes (31)
Species: human : 31 | |
Human | PNPLA3 | 80339 | patatin-like phospholipase domain containing 3 | Variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to nonalcoholic fatty liver disease | Human | RETN | 56729 | resistin | Increased resistin in non-alcoholic fatty liver patients is related to the histological severity of the disease, but do not support a link between resistin and insulin resistance or body mass index in these patients | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Insulin resistance is a major factor controlling ghrelin levels in subjects with and without nonalcoholic fatty liver disease | Human | PPARGC1A | 10891 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PPARGC1A polymorphism and lower expression of PPARGC1A mRNA in the liver are an important genetic contribution to etiology of nonalcoholic fatty liver disease | Human | SLC25A13 | 10165 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | Patients presenting with non-alcoholic fatty liver unrelated to obesity and metabolic syndrome might have citrin deficiency, caused by SLC25A13 gene mutations | Human | CLOCK | 9575 | clock circadian regulator | Our study suggests a potential role of the CLOCK polymorphisms and their haplotypes in susceptibility to nonalcoholic fatty liver disease and disease severity | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | SNPs 45TT and 276GT are significantly more prevalent in nonalcoholic fatty liver disease than in the general population; they are associated with blunted postprandial adiponectin response Decreased levels of blood adiponecin in nonalcoholic fatty liver are related to hepatic insulin sensitivity and to the amount of hepatic fat content | Human | TNF | 7124 | tumor necrosis factor | TNF polymorphisms, which influence TNF production, might be associated with the progression of non-alcoholic fatty liver disease elevated production of IL-1alpha and TNF-alpha by in vitro stimulated whole blood cell cultures occurs in non-alcoholic fatty liver disease obese patients | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | The combination of high AT and TGF-beta1 producing polymorphisms is associated with advanced hepatic fibrosis in obese patients with non-alcoholic fatty liver disease Data show no difference between serum concentrations of transforming growth factor-beta1 and ferritin in fatty liver and non-alcoholic steatohepatitis, suggesting that these forms share more common aspects than previously thought | Human | SREBF1 | 6720 | sterol regulatory element binding transcription factor 1 | in nonalcoholic fatty liver disease, insulin signaling via IRS-1 causes the up-regulation of SREBP1-c, leading to the increased synthesis of fatty acids | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of non-alcoholic steatohepatitis | Human | RBP4 | 5950 | retinol binding protein 4, plasma | Retinol binding protein 4 may contribute to the pathogenesis of nonalcoholic fatty liver disease in type 2 diabetics | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Single nucleotide polymorphismss in the PPAR-gamma, but not PGC-1alpha, gene are associated with non-alcoholic fatty liver disease susceptibility possibly through the adiponectin pathway Both non-alcoholic fatty liver disease and colon cancer may result from distorted mechanisms of PPARg regulation | Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | PPAR-alpha val227ala polymorphism may be involved in the pathogenesis of non-alcoholic fatty liver disease and play a protective role in obesity | Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | The PiMZ alpha1ATD heterozygous state may have a role in worsening liver disease due to hepatitis C virus or nonalcoholic fatty liver disease | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | patients with biopsy-proven non-alcoholic steatohepatitis had higher PAI-1 and lower TAFI-Ag expression than controls | Human | MTTP | 4547 | microsomal triglyceride transfer protein | functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of non-alcoholic steatohepatitis | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | according to this study, the MTHFR C677T mutation does not seem to be a risk factor for the progression of nonalcoholic fatty liver disease to nonalcoholic steatohepatitis | Human | LEPR | 3953 | leptin receptor | Mean serum leptin level and body mass index in the non-alcoholic fatty liver disease (NAFLD) group were significantly higher than in the controls, but mean soluble leptin receptor level was lower in the NAFLD group when compared to the controls | Human | LEP | 3952 | leptin | In nonalcoholic fatty liver disease no relationship between leptin levels and fibrosis stage was demonstrated Findings show a preventive effect of leptin against progressive liver injury in non-alcoholic fatty liver disease | Human | IL1A | 3552 | interleukin 1, alpha | elevated production of IL-1alpha and TNF-alpha by in vitro stimulated whole blood cell cultures occurs in non-alcoholic fatty liver disease obese patients | Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | The induction of HO-1 is an adaptive response against oxidative damage elicited by lipid peroxidation and it may be critical in the progression of non-alcoholic fatty liver | Human | HGF | 3082 | hepatocyte growth factor (hepapoietin A; scatter factor) | Serum HGF levels were higher in non-alcoholic steatohepatitis patients than in the controls | Human | HFE | 3077 | hemochromatosis | HFE mutations may not contribute to iron accumulation in chronic hepatitis C or nonalcoholic fatty liver disease The mild iron overload associated with heterozygosity for C282Y HFE mutation confers susceptibility to nonalcoholic fatty liver disease The presence of H63D mutation found, either heterozygote or homozygote, among the nonalcoholic fatty liver disease patients with peripheral iron overload We review the literature regarding the prevalence, hepatic distribution and possible therapeutic implications of iron overload in chronic hepatitis C, hepatitis B, alcoholic and non-alcoholic fatty liver diseases and porphyria cutanea tarda | Human | GPT | 2875 | glutamic-pyruvate transaminase (alanine aminotransferase) | In obese patients with NAFLD (nonalcoholic fatty liver disease), OSA (obstructive sleep apnea) was associated with elevated alanine aminotransferase levels and a trend toward histologic evidence of progressive liver disease Non-alcoholic fatty liver disease is the most common cause of persistently elevated serum alanine aminotransferase level among the general population of Iran Weight reduction secondary to a hypocaloric diet were associated with improvement in hypertransaminasemia and insulin resistance in nonalcoholic fatty liver disease Histology of nonalcoholic fatty liver disease in individuals with normal ALT values, not significantly different from those with elevated ALT levels, and low normal value does not guarantee freedom from steatohepatitis with advanced fibrosis May serve as a useful marker for non-alcoholic fatty liver disease or diabetes risk in Filipino women |
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