Human | HAVCR2 | 84868 | hepatitis A virus cellular receptor 2 | the -574T > G polymorphism of Tim-3 might be associated with the susceptibility of atopic diseases |
Human | IL21 | 59067 | interleukin 21 | Our findings indicate that IL-21 may influence the production of both human IgE and IgG4, and thus contribute to the regulation of atopic reactions |
Human | CYSLTR2 | 57105 | cysteinyl leukotriene receptor 2 | Title:|Association:Y|Conclusion:Not Found Mutations in cysteinyl leukotriene 2 receptor is associated with atopy |
Human | TLR9 | 54106 | toll-like receptor 9 | Title:Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functionalrelevance.|Association:Not Found|Conclusion:We conclude that common genetic differences in the TLR9 gene exert no major influence on allergy susceptibility, and are unlikely to have on impact on clinical application of CpG-ODNs. |
Human | FOXP3 | 50943 | forkhead box P3 | |
Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | protective effects of hepatitis A virus on atopic disease depends on a common TIM-1 allele Review discusses recent studies demonstrating that the TIM family, particularly TIM-1, plays a critical role in immune responses that regulate the development of atopic diseases |
Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | Title:|Association:Y|Conclusion:Not Found |
Human | NOD1 | 10392 | nucleotide-binding oligomerization domain containing 1 | genetic variants within NOD1 are important determinants of atopy susceptibility |
Human | IL1RL1 | 9173 | interleukin 1 receptor-like 1 | study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations |
Human | SART1 | 9092 | squamous cell carcinoma antigen recognized by T cells | hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy |
Human | IL18R1 | 8809 | interleukin 18 receptor 1 | study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations |
Human | IL18RAP | 8807 | interleukin 18 receptor accessory protein | study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Strong association found between genetic variants of VDR locus and asthma/atopy in Quebec cohort |
Human | SCGB1A1 | 7356 | secretoglobin, family 1A, member 1 (uteroglobin) | study found that infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy |
Human | TNF | 7124 | tumor necrosis factor | tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy |
Human | TLR4 | 7099 | toll-like receptor 4 | Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | FcepsilonRI+ on dendritic cells is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases This largest study to date of genetic variation in TGFB1 and asthma and atopy adds to increasing evidence for a role in these disorders |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | Title:|Association:Not Found|Conclusion:Tunisian persons carrying the glycine-637 of the TAP1 protein may have an increased risk of atopy. Specific association was found between the homozygous TAP1 D/D genotype and allergic asthma. |
Human | STAT6 | 6778 | signal transducer and activator of transcription 6, interleukin-4 induced | genetic variants within STAT6 contribute significantly to IgE regulation and manifestation of atopic diseases As no exonic variants of STAT6 are known as yet, repeat polymorphisms in the regulatory regions and their haplotypes could be important in deciphering the genetic role of STAT6 in asthma and atopy |
Human | SLC11A1 | 6556 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | Title:Atopy in children in relation to BCG vaccination and genetic polymorphisms at SLC11A1 (formerly NRAMP1) and D2S1471.|Association:Not Found|Conclusion:Stratification by BCG vaccination unmasked a potential genetic risk factor for atopy in the region of the SLC11A1 locus, and point to the importance of genotype by environment interactions in determining disease susceptibility. |
Human | SFTPD | 6441 | surfactant protein D | Surfactant protein (SP) D-dependent innate immunity influences atopy and asthma |
Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | Title:Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.|Association:Y|Conclusion: |
Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | Title:|Association:Not Found|Conclusion:Not Found |
Human | RNASE3 | 6037 | ribonuclease, RNase A family, 3 | Presence of ECP in human milk is associated with development of cow milk allergy and atopic dermatitis in the breast-fed infant, but has no direct association with the maternal atopy |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | PTGS2.8473 polymorphism is associated with asthma, atopy and lung function but not plasma IgE in Chinese children |