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Details
Link-It Detail - Disease - Leukemia, Myelomonocytic, Juvenile
Debug Stats
  • ### Total Build Time: 68 ms 58.443 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 428 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 573 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1,014 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 2.806 KB
  • CONCEPT_RELATIONSHIPS gt=37 ms Completed: 37 ms rowSize= 16.797 KB
  • CONCEPT_GENES gt=15 ms Completed: 15 ms rowSize= 35.487 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.168 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Leukemia, Myelomonocytic, Juvenile C0349639
Juvenile Myelomonocytic Leukemia
Definition (1)
A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic proliferation is seen in the bone marrow and the blood. The leukemic cells may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory tract are the most common sites of involvement. The prognosis is usually poor. (WHO, 2001)
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Leukemia, Myeloid C0023470
img Myelodysplastic-Myeloproliferative Diseases C1301355
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Leukemia, Myeloid C0023470
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Myelodysplastic-Myeloproliferative Diseases C1301355
Relationships (58)

Relation Types:
diso_​to_​anat : 10
diso_​to_​chem : 4
diso_​to_​diso : 31
diso_​to_​gene : 6
diso_​to_​phen : 5
diso_​to_​phys : 2


Relationships:
none : 11
gene_​associated_​with_​disease : 4
is_​abnormal_​cell_​of_​disease : 4
is_​associated_​anatomic_​site_​of : 2
is_​associated_​disease_​of : 1
is_​finding_​of_​disease : 6
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​cytogenetic_​abnormality_​of_​disease : 2
is_​not_​finding_​of_​disease : 1
is_​not_​molecular_​abnormality_​of_​disease : 1
may_​be_​associated_​disease_​of_​disease : 3
may_​be_​cytogenetic_​abnormality_​of_​disease : 1
may_​be_​finding_​of_​disease : 13
may_​be_​molecular_​abnormality_​of_​disease : 2
permuted_​term_​of : 1
related_​to : 2
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN58img genetic aspects C0017399
DISO_to_DISO19img Complication Aspects C1171258
DISO_to_PHYS16img Mutation C0026882
DISO_to_DISO10img Dysmyelopoietic Syndromes C0026986
DISO_to_CHEM7img CBL E3 Ubiquitin Protein Ligase C0139026
DISO_to_CHEM7img Protein Tyrosine Phosphatase, Non-Receptor Type 11 C0656342
DISO_to_CHEM7img Proto-Oncogene Proteins c-cbl C0139026
DISO_to_CHEM5img Granulocyte-Macrophage Colony-Stimulating Factor C0079460
DISO_to_DISO5img Noonan Syndrome C0028326
DISO_to_GENE5img Genes, ras C0034677
DISO_to_PHYS5img Germ-Line Mutation C0206530
DISO_to_ANATis_associated_anatomic_site_ofimg Bone Marrow C0005953
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow Stem Cell C1511246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Haematopoietic tissue C0229619
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Myeloid Cell C1514039
DISO_to_DISOis_associated_disease_ofimg Anemia C0002871
DISO_to_DISOis_not_finding_of_diseaseimg Auer Rods Present C1332354
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg BCR-ABL1 Fusion Protein Expression C1516132
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Bronchitis C0006277
Genes (24)

Species:
human : 24
SpeciesGeneGeneIdGene NameEvidence
HumanSPECC192521sperm antigen with calponin homology and coiled-coil domains 1
img NCI, Score=801, Pubmed Id: 15087372, UMLKSK CUI: C0349639
HumanARHGAP2623092Rho GTPase activating protein 26
img NCI, Score=801, Pubmed Id: 15382263, UMLKSK CUI: C0349639
HumanCD839308CD83 molecule
img NCI, Score=801, Pubmed Id: 12522453, UMLKSK CUI: C0349639
HumanCCL226367chemokine (C-C motif) ligand 22
img NCI, Score=801, Pubmed Id: 12522453, UMLKSK CUI: C0349639
HumanPTPN115781protein tyrosine phosphatase, non-receptor type 11
Click here to display 35 evidence detail records.
HumanPDGFRB5159platelet-derived growth factor receptor, beta polypeptide
img NCI, Score=801, Pubmed Id: 15087372, UMLKSK CUI: C0349639
HumanMX14599myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
img NCI, Score=801, Pubmed Id: 15454834, UMLKSK CUI: C0349639
HumanMPL4352myeloproliferative leukemia virus oncogene
img NCI, Score=801, Pubmed Id: 9596651, UMLKSK CUI: C0349639
HumanIRF23660interferon regulatory factor 2
img NCI, Score=801, Pubmed Id: 10609788, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 10609788, UMLKSK CUI: C0349639
HumanIL13RA23598interleukin 13 receptor, alpha 2
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
HumanIL133596interleukin 13
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
HumanIL33562interleukin 3 (colony-stimulating factor, multiple)
img NCI, Score=801, Pubmed Id: 1886426, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 1915702, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 8641332, UMLKSK CUI: C0349639
HumanIL1A3552interleukin 1, alpha
img NCI, Score=801, Pubmed Id: 1915702, UMLKSK CUI: C0349639
HumanHBA23040hemoglobin, alpha 2
img NCI, Score=801, Pubmed Id: 7795240, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 7795240, UMLKSK CUI: C0349639
HumanFANCG2189Fanconi anemia, complementation group G
img NCI, Score=801, Pubmed Id: 10994546, UMLKSK CUI: C0349639
HumanFANCA2175Fanconi anemia, complementation group A
img NCI, Score=801, Pubmed Id: 10994546, UMLKSK CUI: C0349639
HumanCSF1R1436colony stimulating factor 1 receptor
img NCI, Score=801, Pubmed Id: 2968914, UMLKSK CUI: C0349639
HumanCPOX1371coproporphyrinogen oxidase
img NCI, Score=801, Pubmed Id: 10609786, UMLKSK CUI: C0349639
HumanCD38952CD38 molecule
img NCI, Score=801, Pubmed Id: 8839860, UMLKSK CUI: C0349639
HumanCD80941CD80 molecule
img NCI, Score=801, Pubmed Id: 12522453, UMLKSK CUI: C0349639
HumanCD14929CD14 molecule
img NCI, Score=801, Pubmed Id: 9012477, UMLKSK CUI: C0349639
HumanCD1D912CD1d molecule
img NCI, Score=801, Pubmed Id: 12764370, UMLKSK CUI: C0349639
HumanCA1759carbonic anhydrase I
img NCI, Score=801, Pubmed Id: 807771, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 807771, UMLKSK CUI: C0349639
HumanANXA2302annexin A2
img NCI, Score=801, Pubmed Id: 12699894, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 12699894, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 12699894, UMLKSK CUI: C0349639
img NCI, Score=801, Pubmed Id: 12699894, UMLKSK CUI: C0349639
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0349639Leukemia, Myelomonocytic, Juvenile0self