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Genes (18)
Species: human : 18 | |
Human | MIR184 | 406960 | microRNA 184 | overexpression of miR-184 might play an oncogenic role in the antiapoptotic and proliferative processes of tongue squamous cell carcinoma; in addition, plasma miR-184 levels were associated with the presence of primary tumor | Human | FXYD5 | 53827 | FXYD domain containing ion transport regulator 5 | Expressions of dysadherin and E-cadherin were investigated immunohistochemically in 91 patients with squamous cell carcinoma of the tongue to determine the correlation between the 2 molecules and their associations with the clinicopathologic features of the tumors and with patient survival. Increased dysadherin expression is a significant indicator of poor prognosis in patients with squamous cell carcinoma of the tongue. | Human | MVP | 9961 | major vault protein | [Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma] METHODS: The expression patterns of Pgp, MRP, LRP, GST-pi and Topo II alpha in 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohistochemically labelled streptavidin bioein method (LsAB). | Human | CXCL14 | 9547 | chemokine (C-X-C motif) ligand 14 | Using a peptide-specific antiserum, abundant expression of BRAK protein was found in suprabasal layers of normal tongue mucosa but consistently was absent in tongue SCC. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Therefore, in this study we investigated whether CXCR4 (receptor for stromal cell-derived factor-1) is expressed in squamous cell carcinoma of the tongue. Investigation of CXCR4 in squamous cell carcinoma of the tongue. | Human | VEGFC | 7424 | vascular endothelial growth factor C | OBJECTIVE: To detect the role of Vascular endothelial growth factor C (VEGF-C) in the interaction of tongue squamous cell carcinoma (TSCC) with the peri-carcinoma lymphatics. furin is responsible for VEGF-C processing in human oral tongue squamous cell carcinoma progression | Human | VEGFA | 7422 | vascular endothelial growth factor A | Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | This study was designed to analyze the role of TIMP-2 for activation of MMP-2 and its prognostic value in tongue squamous cell carcinoma (SCC). | Human | FURIN | 5045 | furin (paired basic amino acid cleaving enzyme) | furin is responsible for VEGF-C processing in human oral tongue squamous cell carcinoma progression | Human | NOTCH1 | 4851 | notch 1 | Background information. Involvement of Notch1 signalling in several cancers is well known, but its role in human tongue squamous cell carcinoma, one of the most common carcinomas of the human oral cavity, remains poorly characterized.Results. | Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I oral tongue squamous cell carcinoma | Human | LTA | 4049 | lymphotoxin alpha | An immunohistochemical study was performed to observe the aberrant expression of blood-related group antigens in squamous cell carcinomas of the tongue from 10 patients and 13 normal tongue tissues using seven monoclonal antibodies, A, B, H, X001, H001, Lea and Leb, and four lectins, PNA, VVA-B4, UEA-1 and LTA. | Human | LRP1 | 4035 | low density lipoprotein receptor-related protein 1 | METHODS: The expression patterns of Pgp, MRP, LRP, GST-pi and Topo II alpha in 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohistochemically labelled streptavidin bioein method (LsAB). | Human | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | As a result, interfering with HIF-1alpha pathways by antisense or siRNA strategy may provide a therapeutic target for human tongue squamous cell carcinomas. We investigated the effect of HIF-1alpha knockout on the in vitro survival and death of human tongue squamous cell carcinomas (SCC-4 and SCC-9). Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. | Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | p21WAF1/CIP1 may have a role in oral tongue squamous cell carcinoma progression | Human | CCNB1 | 891 | cyclin B1 | EXPERIMENTAL DESIGN: To determine the role of cyclin B1 in SCC of the tongue, we analyzed tumor specimens from 41 patients with stage II-IV SCC of the tongue who underwent curative surgery using immunohistochemistry. CONCLUSIONS: Our study indicates that cyclin B1 is overexpressed in a subset of SCC of the tongue and is associated with a more aggressive biological behavior of the disease. Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue. | Human | BIRC2 | 329 | baculoviral IAP repeat containing 2 | Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue squamous cell carcinomas | Human | AMFR | 267 | autocrine motility factor receptor, E3 ubiquitin protein ligase | The expression of c-Met, AMFR, and Ets-1 protein was analyzed by immunohistochemistry in 99 patients with tongue SCC. The evaluation of AMFR and c-Met in tongue SCC is valuable in identifying patients at high risk for recurrences and who should be treated as more advanced cases. |
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