Debug Stats | ### Total Build Time: 31 ms 36.414 KB CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 356 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 388 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=1 ms Completed: 1 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=13 ms Completed: 13 ms rowSize= 15.412 KBCONCEPT_GENES gt=6 ms Completed: 6 ms rowSize= 19.042 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.163 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
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Relationships (43)
Relation Types: diso_to_anat : 12 diso_to_diso : 29 diso_to_phen : 2
Relationships: is_abnormal_cell_of_disease : 5 is_associated_anatomic_site_of : 2 is_finding_of_disease : 4 is_normal_cell_origin_of_disease : 2 is_normal_tissue_origin_of_disease : 2 is_not_cytogenetic_abnormality_of_disease : 2 is_not_finding_of_disease : 3 is_not_molecular_abnormality_of_disease : 9 may_be_associated_disease_of_disease : 3 may_be_cytogenetic_abnormality_of_disease : 6 may_be_finding_of_disease : 4 may_be_normal_cell_origin_of_disease : 1 | |
DISO_to_ANAT | | is_associated_anatomic_site_of |
Bone Marrow C0005953 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Bone Marrow Stem Cell C1511246 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Cancer Cell C0334227 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
HEMOLYMPHORETICULAR TISSUE C1512398 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Haematopoietic tissue C0229619 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Hematopoietic and Lymphatic System C1512394 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Hematopoietic and Lymphoid Cell C1512385 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Leukemic Cell C1517806 | DISO_to_ANAT | | may_be_normal_cell_origin_of_disease |
Multipotent Bone Marrow Stem Cell C1513753 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Hematopoietic and Lymphoid Cell C1513983 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Myeloid Cell C1514039 | DISO_to_DISO | | is_not_finding_of_disease |
Acute Clinical Course C1332147 | DISO_to_DISO | | is_not_molecular_abnormality_of_disease |
BCR-ABL1 Fusion Protein Expression C1516132 | DISO_to_DISO | | is_not_molecular_abnormality_of_disease |
BCR-FGFR1 Fusion Protein Expression C1516133 | DISO_to_DISO | | is_not_molecular_abnormality_of_disease |
BCR-PDGFRA Fusion Protein Expression C1516135 | DISO_to_DISO | | may_be_finding_of_disease |
Charcot-Leyden Crystals Formation C1516443 | DISO_to_DISO | | may_be_cytogenetic_abnormality_of_disease |
Chromosome 13q deletion C2930913 | DISO_to_DISO | | may_be_finding_of_disease |
Chronic Clinical Course C1333035 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Constrictive endocarditis C0264834 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Endomyocardial Fibrosis C0553980 | DISO_to_DISO | | may_be_finding_of_disease |
Enlarged Liver C0019209 | DISO_to_DISO | | may_be_finding_of_disease |
Enlarged Spleen C0038002 | DISO_to_DISO | | is_finding_of_disease |
Eosinophil count raised (finding) C2240374 | DISO_to_DISO | | is_not_molecular_abnormality_of_disease |
FGFR1 Gene Activation C1517090 |
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Genes (12)
Species: human : 12 | |
Human | FIP1L1 | 81608 | factor interacting with PAPOLA and CPSF1 | Fusion protein is detected in hypereosinophilic syndrome and chronic eosinophilic leukemia FIP1L1 and PDGFRalpha have roles in response to imatinib mesylate in chronic eosinophilic leukemia | Human | WT1 | 7490 | Wilms tumor 1 | distinguish between idiopathic hypereosinophilic syndromes/chronic eosinophilic leukemia and reactive hypereosinophilia based on WT1 transcript amount | Human | TCN1 | 6947 | transcobalamin I (vitamin B12 binding protein, R binder family) | Cyclic eosinophilic leukocytosis in eosinophilic leukemia with observations on transcobalamin I and eosinophils. | Human | RNASE3 | 6037 | ribonuclease, RNase A family, 3 | The inhibitory effects of azelastine hydrochloride on PAF-induced and fMLP-induced Ca2+ influx, actin polymerization and calcium ionophore A23187-induced and aggregated IgG-induced release of eosinophil cationic protein (ECP) of an eosinophilic leukaemia cell line, EoL-1, were examined. | Human | RASA1 | 5921 | RAS p21 protein activator (GTPase activating protein) 1 | We report a patient with a myeloproliferative disorder characterized by chronic eosinophilic leukaemia complicated by autoimmune haemolytic anaemia and a previously unreported translocation (3;5)(p13;q13), and discuss the possible contribution of the RASA gene, localized to 5q13.3, to the development of the malignant phenotype. | Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | FIP1L1 and PDGFRalpha have roles in response to imatinib mesylate in chronic eosinophilic leukemia The presence of the FIP1L1-PDGFRA fusion gene is detected in chronic eosinophilic leukemia These results indicate that the fusion of FIP1L1 to PDGFRA occurs rarely in leukemia cell lines, but they identify EOL-1 as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia and for the analysis of small molecule inhibitors of FIP1L1-PDGFRalpha. | Human | ITGB2 | 3689 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | The effects of several cytokines and phorbol myristate acetate (PMA) on LFA-1 and ICAM-1 expression on a human eosinophilic leukemia cell line, EoL-3, were investigated and compared with those of a human monocytic leukemia cell line, U937. | Human | ITGAL | 3683 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | The effects of several cytokines and phorbol myristate acetate (PMA) on LFA-1 and ICAM-1 expression on a human eosinophilic leukemia cell line, EoL-3, were investigated and compared with those of a human monocytic leukemia cell line, U937. Regulation of the expression of leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) on a human eosinophilic leukemia cell line EoL-3. | Human | FCER2 | 2208 | Fc fragment of IgE, low affinity II, receptor for (CD23) | A subclone of the EoL-3 human eosinophilic leukemia cell line (EoL-3.12) was selected for its high inducibility of CD23 (low affinity IgE receptor/Fc epsilon RII) by IL-4. Differential regulation of the low affinity Fc receptor for IgE (Fc epsilon R2/CD23) and the IL-2 receptor (Tac/p55) on eosinophilic leukemia cell line (EoL-1 and EoL-3). Eosinophils from different hypereosinophilic patients as well as the eosinophilic leukemia cell line EoL-3, analyzed by RT-PCR, expressed both CD23 a and b isoforms. The effects of interferon-alpha (IFN-alpha), INF-gamma, transforming growth factor beta (TGF-beta) and dexamethasone on low-affinity Fc receptors for IgE (Fc epsilon R2/CD23) expression on a human eosinophilic leukemia cell line, Eol-3, were examined. | Human | CX3CR1 | 1524 | chemokine (C-X3-C motif) receptor 1 | A human cDNA encoding a putative G protein-coupled receptor designated chemokine beta receptor-like 1 (CMKBRL1) was isolated from an eosinophilic leukemia library. | Human | CSF2 | 1437 | colony stimulating factor 2 (granulocyte-macrophage) | Recombinant GM-CSF stimulation of either eosinophilic leukemia (EoL-1) cells or blood eosinophils in vitro results in reorganization of actin and translocation of alpha-fodrin to the plasma membrane | Human | CD14 | 929 | CD14 molecule | Induction of eosinophilic granules, nonspecific esterase activity and CD14 expression in the human eosinophilic leukemia cell line, EOL-1. |
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