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Details
Link-It Detail - Disease - Chronic eosinophilic leukemia
Debug Stats
  • [ From Cache ]
  • ### Total Build Time: 223 ms 41.545 KB
  • CONCEPT_NAME gt=8 ms Completed: 7 ms rowSize= 356 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 388 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=179 ms Completed: 179 ms rowSize= 20.543 KB
  • CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 19.042 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Chronic eosinophilic leukemia C0346421
Definition (1)
A disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. Chronic eosinophilic leukemia may stay the same for many years, or it may progress quickly to acute leukemia.
Relationships (44)

Relation Types:
diso_​to_​anat : 12
diso_​to_​diso : 30
diso_​to_​phen : 2


Relationships:
is_​abnormal_​cell_​of_​disease : 5
is_​finding_​of_​disease : 4
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​cytogenetic_​abnormality_​of_​disease : 2
is_​not_​finding_​of_​disease : 3
is_​not_​molecular_​abnormality_​of_​disease : 9
is_​primary_​anatomic_​site_​of_​disease : 2
may_​be_​associated_​disease_​of_​disease : 3
may_​be_​cytogenetic_​abnormality_​of_​disease : 6
may_​be_​finding_​of_​disease : 5
may_​be_​normal_​cell_​origin_​of_​disease : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Bone Marrow C0005953
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow Stem Cell C1511246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Haematopoietic tissue C0229619
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATmay_be_normal_cell_origin_of_diseaseimg Multipotent Bone Marrow Stem Cell C1513753
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Myeloid Cell C1514039
DISO_to_DISOis_not_finding_of_diseaseimg Acute Clinical Course C1332147
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg BCR-ABL1 Fusion Protein Expression C1516132
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg BCR-FGFR1 Fusion Protein Expression C1516133
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg BCR-PDGFRA Fusion Protein Expression C1516135
DISO_to_DISOmay_be_finding_of_diseaseimg Charcot-Leyden Crystals Formation C1516443
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Chromosome 13q deletion C2930913
DISO_to_DISOmay_be_finding_of_diseaseimg Chronic Clinical Course C1333035
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Constrictive endocarditis C0264834
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Endomyocardial Fibrosis C0553980
DISO_to_DISOmay_be_finding_of_diseaseimg Enlarged Liver C0019209
DISO_to_DISOmay_be_finding_of_diseaseimg Enlarged Spleen C0038002
DISO_to_DISOis_finding_of_diseaseimg Eosinophil count raised (finding) C2240374
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg FGFR1 Gene Activation C1517090
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg FIP1L1-PDGFRA Fusion Protein Expression C1517097
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Gain of Chromosome 8 C1517422
DISO_to_DISOmay_be_finding_of_diseaseimg Hepatomegaly C0019209
DISO_to_DISOis_finding_of_diseaseimg Hypercellular bone marrow C1334068
DISO_to_DISOis_not_finding_of_diseaseimg Ineffective Hematopoiesis C1334171
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Loss of Chromosome 20q C1517974
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Neuropathy C0442874
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg PDGFRA Gene Mutation C1518782
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg PDGFRA Gene Rearrangement C2707644
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg PDGFRB Gene Rearrangement C2827357
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg PDGFRalpha Protein Overexpression C1518783
DISO_to_DISOis_not_cytogenetic_abnormality_of_diseaseimg Philadelphia Chromosome C0031526
DISO_to_DISOis_not_finding_of_diseaseimg Solid Growth Pattern C1336028
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg del(4)(q12) C1515597
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg t(6;8)(q27;p11) C1515780
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg t(8;9)(p11;q32-34) C1515799
DISO_to_DISOis_not_cytogenetic_abnormality_of_diseaseimg t(9;22)(q34;q11) C1515809
DISO_to_PHENis_finding_of_diseaseimg Blasts Under 20 Percent of Bone Marrow Nucleated Cells C1511213
DISO_to_PHENis_finding_of_diseaseimg Clonal Eosinophils Present C1516668
Genes (12)

Species:
human : 12
SpeciesGeneGeneIdGene NameEvidence
HumanFIP1L181608factor interacting with PAPOLA and CPSF1
img GENERIF, Score=1000, Pubmed Id: 17299092, UMLKSK CUI: C0346421
img GENERIF, Score=1000, Pubmed Id: 16502585, UMLKSK CUI: C0346421
HumanWT17490Wilms tumor 1
img GENERIF, Score=1000, Pubmed Id: 17508006, UMLKSK CUI: C0346421
HumanTCN16947transcobalamin I (vitamin B12 binding protein, R binder family)
img NCI, Score=801, Pubmed Id: 6205742, UMLKSK CUI: C0346421
HumanRNASE36037ribonuclease, RNase A family, 3
img NCI, Score=801, Pubmed Id: 8222744, UMLKSK CUI: C0346421
HumanRASA15921RAS p21 protein activator (GTPase activating protein) 1
img NCI, Score=801, Pubmed Id: 8943895, UMLKSK CUI: C0346421
HumanPDGFRA5156platelet-derived growth factor receptor, alpha polypeptide
img NCI, Score=801, Pubmed Id: 14630792, UMLKSK CUI: C0346421
img GENERIF, Score=1000, Pubmed Id: 17299092, UMLKSK CUI: C0346421
img GENERIF, Score=1000, Pubmed Id: 17137731, UMLKSK CUI: C0346421
HumanITGB23689integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
img NCI, Score=801, Pubmed Id: 1355014, UMLKSK CUI: C0346421
HumanITGAL3683integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
img NCI, Score=801, Pubmed Id: 1355014, UMLKSK CUI: C0346421
img NCI, Score=801, Pubmed Id: 1355014, UMLKSK CUI: C0346421
HumanFCER22208Fc fragment of IgE, low affinity II, receptor for (CD23)
img NCI, Score=801, Pubmed Id: 9620595, UMLKSK CUI: C0346421
img NCI, Score=801, Pubmed Id: 2525145, UMLKSK CUI: C0346421
img NCI, Score=801, Pubmed Id: 1701160, UMLKSK CUI: C0346421
img NCI, Score=801, Pubmed Id: 8589271, UMLKSK CUI: C0346421
HumanCX3CR11524chemokine (C-X3-C motif) receptor 1
img NCI, Score=801, Pubmed Id: 7646814, UMLKSK CUI: C0346421
HumanCSF21437colony stimulating factor 2 (granulocyte-macrophage)
img GENERIF, Score=734, Pubmed Id: 19050289, UMLKSK CUI: C0346421
HumanCD14929CD14 molecule
img NCI, Score=801, Pubmed Id: 7525448, UMLKSK CUI: C0346421
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0346421Chronic eosinophilic leukemia0self