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Genes (13)
Species: human : 13 | |
Human | ERVK7 | 449619 | | HERV-K expression was also common to testicular carcinoma in situ as well as gonocytes of dysgenetic gonads. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | The promoter methylation status of ten candidate genes-CDH13, DLX6, EMX2, HOXA9, HOXB5, MSX1, MSX2, RASSF1A, RUNX3, and SCGB3A1 (alias HIN-1)-was assessed by methylation-specific PCR in seven intratubular germ cell neoplasias and 55 primary TGCTs. | Human | NANOG | 79923 | Nanog homeobox | Hoei-Hansen C E, Almstrup K, Nielsen J E, Brask Sonne S, Graem N, Skakkebaek N E, Leffers H -De Meyts E (2005) Histopathology47, 48-56 Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumoursAims : NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. | Human | ERVK6 | 64006 | | HERV-K expression was also common to testicular carcinoma in situ as well as gonocytes of dysgenetic gonads. | Human | NES | 10763 | nestin | In testicular malignancies, nestin was localised in the Sertoli cells of the seminiferous tubules affected with intratubular germ cell neoplasia, in the hyperplastic Leydig cells associated with these tumours and in some components (mesenchymal and neuroepithelial cells) of teratomas; spermatocytic and non-spermatocytic seminomas were unstained. | Human | TSPY1 | 7258 | testis specific protein, Y-linked 1 | TSPY was also strongly immunostained in early testicular carcinoma in situ (CIS), while seminomatous tumour cells stained less intensely. | Human | ZNF354A | 6940 | zinc finger protein 354A | An initial precursor stage, intratubular germ cell neoplasia (IGCN), is characterized by triploidization and an upregulation of KIT, ALPP, CCDN2, and ZNF354A, and a downregulation of CDKN2D. An initial precursor stage, intratubular germ cell neoplasia (IGCN), is characterized by triploidization and an upregulation of KIT, ALPP, CCDN2, and ZNF354A, and a downregulation of CDKN2D. | Human | NKX3-1 | 4824 | | In the present study we examined the methylation status of the NKX3.1 promoter in relevant primary tumors and cell lines: primary TGCTs (n = 55), intratubular germ cell neoplasias (n = 7), germ cell tumor cell lines (n = 3), primary prostate adenocarcinomas (n = 20), and prostate cancer cell lines (n = 3) by methylation-specific PCR and bisulphite sequencing. | Human | LIPE | 3991 | lipase, hormone-sensitive | Seminiferous tubules with intratubular germ cell neoplasia exhibited intense immunolabeling to the 3 lipid receptors in the surface of neoplastic cells and to HSL in the nucleus. | Human | HOXA9 | 3205 | homeobox A9 | The promoter methylation status of ten candidate genes-CDH13, DLX6, EMX2, HOXA9, HOXB5, MSX1, MSX2, RASSF1A, RUNX3, and SCGB3A1 (alias HIN-1)-was assessed by methylation-specific PCR in seven intratubular germ cell neoplasias and 55 primary TGCTs. | Human | ERVK3 | 2088 | | HERV-K expression was also common to testicular carcinoma in situ as well as gonocytes of dysgenetic gonads. | Human | DAZL | 1618 | deleted in azoospermia-like | Our results demonstrated that expression of DAZL1 protein was consistently observed in scattered cells in all intratubular germ cell neoplasias (IGCN) of the unclassified type, as well as in some of the intratubular seminomas. | Human | CTAG1B | 1485 | cancer/testis antigen 1B | The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. |
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