Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | |
Human | DYNLRB2 | 83657 | dynein, light chain, roadblock-type 2 | Among the total 68 liver cancer samples tested, DNLC2B was down-regulated in 28 cases |
Human | MOB2 | 81532 | MOB kinase activator 2 | Title:Cloning of liver cancer-related gene HCCA2 and association of that gene with liver cancer|Association:Y|Conclusion:The novel gene HCCA2 may be related with the infiltration and proliferation of liver cancer. |
Human | TP53AIP1 | 63970 | tumor protein p53 regulated apoptosis inducing protein 1 | expression of the p53 mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect |
Human | NDRG2 | 57447 | NDRG family member 2 | NDRG2 gene might express differently between normal tissues and cancer tissues, and might play an important role in the development of pancreatic cancer and liver cancer |
Human | GSDMB | 55876 | gasdermin B | GSDML may be a secretory or metabolic product involved in a secretory pathway, and changes in the regulation of GSDML splicing variant transcription and translation may be seen in the development and/or progression of gastrointestinal and hepatic cancers |
Human | YY1AP1 | 55249 | YY1 associated protein 1 | human liver cancer associated gene |
Human | UGT1A3 | 54659 | UDP glucuronosyltransferase 1 family, polypeptide A3 | Title:Variation of hepatic glucuronidation: Novelfunctional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.|Association:Not Found|Conclusion:Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. |
Human | UGT1A9 | 54600 | UDP glucuronosyltransferase 1 family, polypeptide A9 | Title:Variation of hepatic glucuronidation: Novelfunctional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.|Association:Not Found|Conclusion:Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. Title:A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity.|Association:Not Found|Conclusion:In conclusion, the mutant allele with one base insertion in the promoter region of the UGT1A9 gene would alter the level of enzyme expression and the metabolism of those drugs that are substrates of UGT1A9. |
Human | UGT1A7 | 54577 | UDP glucuronosyltransferase 1 family, polypeptide A7 | Title:UDP-Glucuronosyltransferase 1A7 Genetic Polymorphisms Are Associated with Hepatocellular Carcinoma in Japanese Patients with Hepatitis C Virus Infection|Association:Y|Conclusion:The UGT1A7 polymorphisms together with IL-1 beta were associated with the presence of HCC in Japanese HCV-infected patients. Title:UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age.|Association:Y|Conclusion:An inverse dose-response relationship was demonstrated between the detoxifying activity of the UGT1A7 genotypes and HCC. Of the male HCC patients, median onset age for those carrying an UGT1A7 low-activity genotype was 9 yr lower than those bearing the high-activity variant. |
Human | UGT1A8 | 54576 | UDP glucuronosyltransferase 1 family, polypeptide A8 | Title:Variation of hepatic glucuronidation: Novelfunctional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.|Association:Not Found|Conclusion:Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. |
Human | MAT2B | 27430 | methionine adenosyltransferase II, beta | Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B |
Human | GNMT | 27232 | glycine N-methyltransferase | GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models |
Human | GNL3 | 26354 | guanine nucleotide binding protein-like 3 (nucleolar) | Data suggest that nucleostemin can help regulate the proliferation of both cancer cells and stem cells, and may play an important role in the growth regulation of gastric cancer, liver cancer and other cancers |
Human | PEG10 | 23089 | paternally expressed 10 | Overexpression of PEG10 is associated with hepatic cancer |
Human | DLC1 | 10395 | deleted in liver cancer 1 | Involved in signal transduction pathway regulating cell proliferation, cell morphology, and cell migration in liver cancers |
Human | FSTL3 | 10272 | follistatin-like 3 (secreted glycoprotein) | Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver. in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer |
Human | SLC9A3R1 | 9368 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | the EBP50/beta-catenin complex promotes Wnt signaling, and over-expression of EBP50 may work cooperatively with beta-catenin in the development of liver cancer |
Human | DIRAS3 | 9077 | DIRAS family, GTP-binding RAS-like 3 | provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens |
Human | ABCB11 | 8647 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Increased risk of hepatocellular carcinoma |
Human | PARG | 8505 | poly (ADP-ribose) glycohydrolase | PPAR gamma ligands inhibit growth and induce apoptosis of liver cancer cell |
Human | AXIN1 | 8312 | axin 1 | |
Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | in liver cancers ADAM12 expression is associated with tumor aggressiveness and progression |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Title:Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity.|Association:Not Found|Conclusion:Our findings suggest that genetic modulation of carcinogen metabolism and DNA repair can alter susceptibility to HCC and that these effects may be modified by environmental factors. |
Human | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | analysis of Wnt/beta-catenin and Myc signaling in liver cancer |