Human | UTS2D | 257313 | | Elevated serum urotensin II is associated with chronic liver disease and portal hypertension |
Human | MIA2 | 117153 | melanoma inhibitory activity 2 | Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases |
Human | AICDA | 57379 | activation-induced cytidine deaminase | Findings suggest that the aberrant expression of AID is observed in human hepatocytes with several pathological settings, including chronic liver disease and hepatocellular carcinoma |
Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | CLD (chronic liver disease) is associated with alterations in RANKL/OPG serum levels, which could modulate bone loss in CLD |
Human | TP53 | 7157 | tumor protein p53 | study examined the presence of mutations in TP53 at codon 249 (Ser-249, considered as a hallmark of mutagenesis by aflatoxin) and in CTNNB1 in circulating free DNA of patients with hepatocellular carcinoma or chronic liver disease from Alexandria, Egypt |
Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | TNFalphaRII levels were assessed in chronic liver diseases as possible marker to assess severity of disease/response to treatment |
Human | THPO | 7066 | thrombopoietin | Report thrombopoietin level in patients with chronic liver diseases |
Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | P-selectin elevation in chronic liver disease may suggest a possible pathogenetic role in the course of liver cirrhosis |
Human | PON1 | 5444 | paraoxonase 1 | active role of PON1 in the regulation of oxidative stress, fibrosis and hepatic cell apoptosis in chronic liver diseases |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | MMP-9 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases |
Human | MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | MMP-3 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases |
Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | MMP-1 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases |
Human | KRT8 | 3856 | keratin 8 | A study of 1668 liver disease patients showed that there is no association between the KRT8 mutations Y54H and G62C and chronic liver disease |
Human | IL10 | 3586 | interleukin 10 | Il-10 levels were assessed in chronic liver diseases as possible marker to assess severity of disease/response to treatment |
Human | IL6ST | 3572 | interleukin 6 signal transducer (gp130, oncostatin M receptor) | involvement of IL-6 in the pathogenesis of liver diseases and suggest a protective role of IL-6/gp130-dependent pathways in nonparenchymal liver cells during fibrosis progression in chronic liver diseases |
Human | HFE | 3077 | hemochromatosis | Iron overload is not related to H63D mutation but is positively correlated with biochemical activity and Child-Pugh score in chronic liver diseases |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | GST-pi can be used as a diagnostic marker for hepatocellular carcinoma as well as in detecting other chronic liver diseases |
Human | GHR | 2690 | growth hormone receptor | The increase in nuclear expression of GHR with advanced stages of chronic liver disease suggests that GH may act directly at the nuclear level to promote hepatocyte proliferation/regeneration |
Human | F2 | 2147 | coagulation factor II (thrombin) | Protein induced by vitamin K absence or antagonist-II (PIVKA-II) ia as useful surveillance tool for differentiating hepatocellular carcinoma from chronic liver disease |
Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | study examined the presence of mutations in TP53 at codon 249 (Ser-249, considered as a hallmark of mutagenesis by aflatoxin) and in CTNNB1 in circulating free DNA of patients with hepatocellular carcinoma or chronic liver disease from Alexandria, Egypt |
Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | results suggested that p21 is up-regulated by the stress of inflammation and fibrosis in hepatitis C virus (HCV)-associated chronic liver diseases and that high p21 expression might be related to hepatocarcinogenesis in cirrhotic patients |
Human | CD40 | 958 | CD40 molecule, TNF receptor superfamily member 5 | Results suggest that hepatocyte over-expression of CD40 might play an important role in regulating hepatocyte survival and death in HCV-associated chronic liver diseases |
Human | CD34 | 947 | CD34 molecule | CD34 antigen may play a role in hepatocarcinogenesis in patients with HBV-associated chronic liver diseases |
Human | C5 | 727 | complement component 5 | There is no evidence that these C5 single nucleotide polymorphisms are genetic risk factors for the development of advanced fibrosis in chronic HCV infection or other chronic liver diseases |