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Genes (167)
Species: human : 158 mouse : 9 | |
Mouse | DCD | 117159 | dermcidin | Human cachexia-associated protein (HCAP) was recently identified from a breast cancer library based on the available 20-amino acid sequence of proteolysis-inducing factor (PIF), which is a highly active cachectic factor isolated from mouse colon adenocarcinoma MAC16. | Mouse | ABCC3 | 8714 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Reduction of endogenous VDR expression in colon adenocarcinoma MCA-38 cells by siRNA transfection was associated with reduced constitutive and inducible expression of the Mrp3 gene. | Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | In athymic nude mice bearing subcutaneous human HT29 colon adenocarcinoma xenografts, Ku86 ASO-P85-g-PEI (2 kDa) administration (15 mg/kg, subcutaneously) with a Q1D x 7 treatment schedule, when combined with a single dose of IR (6 Gy), caused a significant inhibition of HT29 tumor growth compared with mismatch- and naked antisense-pretreated control groups (time from 200 to 1000 mm3, 126.9 versus 84.18 and 87.76 days, P<0.005). | Mouse | TNFSF4 | 7292 | tumor necrosis factor (ligand) superfamily, member 4 | To investigate this hypothesis, s.c. established tumors of three different mouse cancer cells (B16 melanoma, H-2b; Lewis lung carcinoma, H-2b; and Colon-26 colon adenocarcinoma, H-2d) were treated with intratumoral injection of a recombinant adenovirus vector expressing mouse OX40L (AdOX40L). | Mouse | SMAD3 | 4088 | SMAD family member 3 | Mice deficient in Smad3 develop colonic adenocarcinoma. | Mouse | ITGAL | 3683 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | The adhesion of anti-CD3-stimulated T cells to syngeneic MCA-38 mouse colon adenocarcinoma cells did not involve LFA-1 (alpha(L)beta(2)) or VLA-5 (alpha(5)beta(1)). | Mouse | IL15 | 3600 | interleukin 15 | Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells. | Mouse | GUCA2B | 2981 | guanylate cyclase activator 2B (uroguanylin) | Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. | Mouse | CSK | 1445 | c-src tyrosine kinase | Overexpression of Csk decreased Src tyrosine kinase activity in NL-17 cells, the highly metastatic clone of mouse colon adenocarcinoma 26. Overexpression of Csk decreased Src tyrosine kinase activity in NL-17 cells, the highly metastatic clone of mouse colon adenocarcinoma 26. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | The levels of mRNA corresponding to the MUC1, MUC2, MUC5AC, MUC5B, and MUC6 genes were determined in 19 human colon adenocarcinoma cell lines by the reverse transcriptase-polymerase chain reaction method using specific primers in an attempt to correlate to the levels of cell surface carbohydrate epitopes. Colon adenocarcinoma cell lines varied in MUC2 expression levels, and one colon adenocarcinoma cell line, HT-29, had higher levels of MUC5 than MUC2. | Human | SFTPA1 | 653509 | surfactant protein A1 | Hydrolyzed soybean isolates SP-A and SP-B (Abbott Laboratories, OH), developed for use in enteral nutritional products, were tested in cultures of C2BBe cells, a colonic adenocarcinoma cell line with enterocytic differentiation, to evaluate effects on cell growth, maturation and ability to resist infection by enteric bacteria. | Human | AASDH | 132949 | aminoadipate-semialdehyde dehydrogenase | Human 2-aminoadipic 6-semialdehyde dehydrogenase gene was cloned; its mRNA is ubiquitously expressed in adult tissues and is highly expressed in colon adenocarcinoma (CX-1) and colon adenocarcinoma (GI-112) cell lines | Human | CAMK2N2 | 94032 | calcium/calmodulin-dependent protein kinase II inhibitor 2 | To investigate its biological functions, full-length human CaM-KIIN was overexpressed in colon adenocarcinoma LoVo cells. | Human | MCM8 | 84515 | minichromosome maintenance complex component 8 | In several cases of colon adenocarcinoma MCM8 expression is greatly reduced relative to matched non-cancerous tissue. | Human | REG4 | 83998 | regenerating islet-derived family, member 4 | Methods: To determine the signaling pathway(s) responsive to Reg IV, we examined the effects of purified recombinant human Reg IV (rhR4) on HCT116 and HT29 colon adenocarcinoma cells. Reg IV Activates the Epidermal Growth Factor Receptor/Akt/AP-1 Signaling Pathway in Colon Adenocarcinomas. Addition of exogenous recombinant human Reg IV to human colon adenocarcinoma cells significantly increased Bcl-2 and Bcl-xL expression and induced resistance to ionizing radiation. | Human | QTRT1 | 81890 | queuine tRNA-ribosyltransferase 1 | Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | Increased MUC1, MUC2, and MUC3 epitopes were present in colon adenocarcinomas of all histological subtypes, with the greatest increase of MUC2 epitopes observed in colloid (mucinous) colon cancers. | Human | CGN | 57530 | cingulin | Cingulin was detected in a metastasis from a colon adenocarcinoma but not in nonepithelial tissues and neoplasias, suggesting that cingulin may be a useful marker in the characterization of colonic and probably other epithelial neoplasias. | Human | PPM1H | 57460 | protein phosphatase, Mg2+/Mn2+ dependent, 1H | PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein | Human | C21orf7 | 56911 | | TAKL was also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3. | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. | Human | UGT1A6 | 54578 | UDP glucuronosyltransferase 1 family, polypeptide A6 | While UGT1A6 induction was clearly detectable in NAD(P)H:quinone oxidoreductase 1 (NQO1)-deficient Caco-2 cells, it was not induced in NQO1-efficient HT-29 colon adenocarcinoma cells. | Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells were engineered using retroviral vectors to release single-chain IL-23 (scIL-23) to evaluate its antitumor activity. | Human | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | We investigated TWEAK sensitivity, TWEAK effects on nuclear factor-kappaB activation, and expression of TWEAK in the HT-29, LS180, SK-CO-1 and SW480 human colonic adenocarcinoma cell lines, all of which express the TWEAK receptor (Fn14). In contrast, TWEAK binding to Fn14/TweakR activated the NF-kappa B and c-Jun N-terminal kinase pathways but induced only a weak activation of MAPK in HT-29 human colon adenocarcinoma cells expressing endogenous Fn14/TweakR. | Human | LRP12 | 29967 | low density lipoprotein receptor-related protein 12 | To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. |
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