Debug Stats | ### Total Build Time: 35 ms 42.373 KB CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 408 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 554 bytes- Skipping details on:
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CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1.396 KBCONCEPT_CHILDREN gt=1 ms Completed: 1 ms rowSize= 566 bytesCONCEPT_ANCESTRAL_ROOTS gt=10 ms Completed: 10 ms rowSize= 7.927 KBCONCEPT_RELATIONSHIPS gt=5 ms Completed: 5 ms rowSize= 9.391 KBCONCEPT_GENES gt=11 ms Completed: 11 ms rowSize= 20.798 KBCONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.160 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
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Genes (16)
Species: human : 16 | |
Human | MALAT1 | 378938 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | JAZF1 | 221895 | JAZF zinc finger 1 | The JAFZ1-JJAZ1 fusion gene is present in the endometrial stromal and smooth muscle components of endometrial stromal tumors Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Both benign and malignant forms of endometrial stromal tumor have the JAZF1-JJAZ1 fusion, but only the malignant form also exhibits exclusion of the unrearranged JJAZ1 allele Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes. Endometrial stromal tumors (ESTs), including low-grade endometrial stromal sarcomas (LGESSs) and endometrial stromal nodules (ESNs) of classic histology, exhibit characteristic morphologic features and contain the nonrandom t(7;17)(p15; q21), which results in the fusion of two novel genes, JAZF1 and JJAZ1. The JAZF1-JJAZ1 fusion is a frequent, although nonuniform, feature of endometrial stromal neoplasia In comparison to published data, our results identified the JAZF1/JJAZ1 gene fusion more frequently in endometrial stromal tumors than hitherto presumed. | Human | SUZ12 | 23512 | SUZ12 polycomb repressive complex 2 subunit | Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. In comparison to published data, our results identified the JAZF1/JJAZ1 gene fusion more frequently in endometrial stromal tumors than hitherto presumed. Endometrial stromal tumors (ESTs), including low-grade endometrial stromal sarcomas (LGESSs) and endometrial stromal nodules (ESNs) of classic histology, exhibit characteristic morphologic features and contain the nonrandom t(7;17)(p15; q21), which results in the fusion of two novel genes, JAZF1 and JJAZ1. Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes. | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | SFRP4 | 6424 | secreted frizzled-related protein 4 | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | SDHD | 6392 | succinate dehydrogenase complex, subunit D, integral membrane protein | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | SDHC | 6391 | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | SDHB | 6390 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | MME | 4311 | membrane metallo-endopeptidase | CD10 may play a useful role in aiding the differential between endometrial stromal tumors in the ovary and SCST and stromal tumors | Human | CD99 | 4267 | CD99 molecule | The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle tumors, three endometrial stromal tumors, two mixed endometrial stromal and smooth muscle tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. | Human | INHA | 3623 | inhibin, alpha | Inhibin alpha immunostaining was identified in 46 (81%) of 57 gonadal stromal tumors, one (14%) of seven endometrial stromal tumors, and one (50%) of two primary ovarian carcinoid tumors. | Human | GNRHR | 2798 | gonadotropin-releasing hormone receptor | INFERRED, Score=800, UMLKSK CUI: C0334695 | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | nuclear beta-catenin immunostaining can serve as a sensitive immunohistochemical marker for the diagnosis of endometrial stromal tumors | Human | ACTC1 | 70 | actin, alpha, cardiac muscle 1 | INFERRED, Score=800, UMLKSK CUI: C0334695 |
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