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Details
Link-It Detail - Disease - Lymphoma, Mantle-Cell
Debug Stats
  • ### Total Build Time: 42 ms 57.727 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 440 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 519 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 557 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=3 ms Completed: 3 ms rowSize= 4.072 KB
  • CONCEPT_RELATIONSHIPS gt=12 ms Completed: 12 ms rowSize= 15.415 KB
  • CONCEPT_GENES gt=21 ms Completed: 21 ms rowSize= 35.385 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Lymphoma, Mantle-Cell C0334634
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
Definition (1)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Lymphoma, Non-Hodgkin C0024305
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210706img Lymphoma, Non-Hodgkin C0024305
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242286img Lymphoma, Non-Hodgkin C0024305
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Lymphoma, Non-Hodgkin C0024305
Relationships (93)

Relation Types:
diso_​to_​anat : 25
diso_​to_​chem : 21
diso_​to_​diso : 39
diso_​to_​phen : 2
diso_​to_​phys : 6


Relationships:
none : 49
entry_​version_​of : 1
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 3
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 14
may_​be_​cytogenetic_​abnormality_​of_​disease : 4
may_​be_​finding_​of_​disease : 2
may_​be_​molecular_​abnormality_​of_​disease : 2
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN167img genetic aspects C0017399
DISO_to_PHEN163img genetic aspects C0017399
DISO_to_CHEM75img Antineoplastic Agents C0003392
DISO_to_DISO58img Complication Aspects C1171258
DISO_to_CHEM51img Antibodies, Monoclonal C0003250
DISO_to_DISO45img Complication Aspects C1171258
DISO_to_CHEM43img Antibodies, Monoclonal C0003250
DISO_to_CHEM42img Acids, Boronic C0006032
DISO_to_CHEM42img Pyrazines C0034240
DISO_to_CHEM41img Antineoplastic Agents C0003392
DISO_to_CHEM33img Cyclin D1 C0174680
DISO_to_CHEM32img Cyclin D1 C0174680
DISO_to_DISO32img Lymphoma, Follicular C0024301
DISO_to_DISO30img Chronic Lymphocytic Leukemia C0023434
DISO_to_DISO28img Chromosomal translocation C0040715
DISO_to_CHEM27img BIOCHEM TUMOR MARKERS C0041366
DISO_to_DISO26img B-Cell Lymphomas C0079731
DISO_to_DISO26img Lymphoma, Follicular C0024301
DISO_to_DISO25img Chronic Lymphocytic Leukemia C0023434
DISO_to_PHYS23img Apoptosis C0162638
DISO_to_ANAT22img Chromosome 11 C0008653
DISO_to_PHYS22img GENE EXPRESSION REG NEOPL C0017268
DISO_to_DISO20img B-Cell Lymphomas C0079731
DISO_to_DISO20img LOCAL NEOPL RECURRENCE C0027643
DISO_to_DISO19img Diffuse Large B-Cell Lymphoma C0079744
Genes (100)

Species:
human : 100
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
img NCI, Score=801, Pubmed Id: 16025281, UMLKSK CUI: C0334634
HumanZNF804A91752zinc finger protein 804A
img NCI, Score=801, Pubmed Id: 12970790, UMLKSK CUI: C0334634
HumanMUM184939melanoma associated antigen (mutated) 1
img NCI, Score=801, Pubmed Id: 16918993, UMLKSK CUI: C0334634
HumanWNT10A80326wingless-type MMTV integration site family, member 10A
img GENERIF, Score=923, Pubmed Id: 18787224, UMLKSK CUI: C0334634
HumanAICDA57379activation-induced cytidine deaminase
img NCI, Score=801, Pubmed Id: 15781912, UMLKSK CUI: C0334634
img GENERIF, Score=1000, Pubmed Id: 14551145, UMLKSK CUI: C0334634
HumanPBK55872PDZ binding kinase
img NCI, Score=801, Pubmed Id: 14757441, UMLKSK CUI: C0334634
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
img NCI, Score=801, Pubmed Id: 15163014, UMLKSK CUI: C0334634
HumanCHEK211200checkpoint kinase 2
img NCI, Score=801, Pubmed Id: 15020270, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 12393693, UMLKSK CUI: C0334634
HumanMALT110892mucosa associated lymphoid tissue lymphoma translocation gene 1
img NCI, Score=801, Pubmed Id: 14997743, UMLKSK CUI: C0334634
HumanSEMA4D10507sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0334634
HumanTUBGCP310426tubulin, gamma complex associated protein 3
img NCI, Score=801, Pubmed Id: 17236200, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 17236200, UMLKSK CUI: C0334634
HumanAPOBEC3B9582apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
img NCI, Score=801, Pubmed Id: 16042692, UMLKSK CUI: C0334634
HumanLITAF9516lipopolysaccharide-induced TNF factor
img NCI, Score=801, Pubmed Id: 16960149, UMLKSK CUI: C0334634
HumanABCG29429ATP-binding cassette, sub-family G (WHITE), member 2
img GENERIF, Score=1000, Pubmed Id: 17701580, UMLKSK CUI: C0334634
HumanBCL108915B-cell CLL/lymphoma 10
Click here to display 8 evidence detail records.
HumanDLEU28847deleted in lymphocytic leukemia 2 (non-protein coding)
img NCI, Score=801, Pubmed Id: 11072235, UMLKSK CUI: C0334634
HumanTNFRSF10A8797tumor necrosis factor receptor superfamily, member 10a
img GENERIF, Score=1000, Pubmed Id: 16217763, UMLKSK CUI: C0334634
HumanNR0B28431nuclear receptor subfamily 0, group B, member 2
img NCI, Score=801, Pubmed Id: 14614518, UMLKSK CUI: C0334634
HumanTCL1A8115T-cell leukemia/lymphoma 1A
img NCI, Score=801, Pubmed Id: 10786666, UMLKSK CUI: C0334634
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 11368435, UMLKSK CUI: C0334634
HumanTTK7272TTK protein kinase
img GENERIF, Score=923, Pubmed Id: 16080195, UMLKSK CUI: C0334634
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 18467333, UMLKSK CUI: C0334634
HumanTOP2A7153topoisomerase (DNA) II alpha 170kDa
img GENERIF, Score=1000, Pubmed Id: 15201855, UMLKSK CUI: C0334634
HumanTERF27014telomeric repeat binding factor 2
img NCI, Score=801, Pubmed Id: 15476325, UMLKSK CUI: C0334634
HumanTAL16886T-cell acute lymphocytic leukemia 1
img NCI, Score=801, Pubmed Id: 11781220, UMLKSK CUI: C0334634
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0334634Lymphoma, Mantle-Cell0self