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Details
Link-It Detail - Disease - Lymphoma, Mantle-Cell
Debug Stats
  • ### Total Build Time: 291 ms 57.774 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 340 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 648 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=11 ms Completed: 11 ms rowSize= 557 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 4.072 KB
  • CONCEPT_RELATIONSHIPS gt=183 ms Completed: 183 ms rowSize= 15.415 KB
  • CONCEPT_GENES gt=72 ms Completed: 72 ms rowSize= 35.404 KB
  • CONCEPT_XREFS gt=9 ms Completed: 9 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Lymphoma, Mantle-Cell C0334634
Definition (1)
An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Lymphoma, Non-Hodgkin C0024305
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210706img Lymphoma, Non-Hodgkin C0024305
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242286img Lymphoma, Non-Hodgkin C0024305
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Lymphoma, Non-Hodgkin C0024305
Relationships (94)

Relation Types:
diso_​to_​anat : 25
diso_​to_​chem : 22
diso_​to_​diso : 39
diso_​to_​phen : 2
diso_​to_​phys : 6


Relationships:
none : 50
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 3
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 14
may_​be_​cytogenetic_​abnormality_​of_​disease : 4
may_​be_​finding_​of_​disease : 2
may_​be_​molecular_​abnormality_​of_​disease : 2
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN167img genetic aspects C0017399
DISO_to_PHEN163img genetic aspects C0017399
DISO_to_CHEM75img Antineoplastic Agents C0003392
DISO_to_DISO58img Complication Aspects C1171258
DISO_to_CHEM51img Antibodies, Monoclonal C0003250
DISO_to_DISO45img Complication Aspects C1171258
DISO_to_CHEM43img Antibodies, Monoclonal C0003250
DISO_to_CHEM42img Acids, Boronic C0006032
DISO_to_CHEM42img Pyrazines C0034240
DISO_to_CHEM41img Antineoplastic Agents C0003392
DISO_to_CHEM33img Cyclin D1 C0174680
DISO_to_CHEM32img Cyclin D1 C0174680
DISO_to_DISO32img Lymphoma, Follicular C0024301
DISO_to_DISO30img Chronic Lymphocytic Leukemia C0023434
DISO_to_DISO28img Chromosomal translocation C0040715
DISO_to_CHEM27img BIOCHEM TUMOR MARKERS C0041366
DISO_to_DISO26img B-Cell Lymphomas C0079731
DISO_to_DISO26img Lymphoma, Follicular C0024301
DISO_to_DISO25img Chronic Lymphocytic Leukemia C0023434
DISO_to_PHYS23img Apoptosis C0162638
DISO_to_ANAT22img Chromosome 11 C0008653
DISO_to_PHYS22img GENE EXPRESSION REG NEOPL C0017268
DISO_to_DISO20img B-Cell Lymphomas C0079731
DISO_to_DISO20img LOCAL NEOPL RECURRENCE C0027643
DISO_to_DISO19img Diffuse Large B-Cell Lymphoma C0079744
Genes (100)

Species:
human : 100
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
img NCI, Score=801, Pubmed Id: 16025281, UMLKSK CUI: C0334634
HumanZNF804A91752zinc finger protein 804A
img NCI, Score=801, Pubmed Id: 12970790, UMLKSK CUI: C0334634
HumanMUM184939melanoma associated antigen (mutated) 1
img NCI, Score=801, Pubmed Id: 16918993, UMLKSK CUI: C0334634
HumanWNT10A80326wingless-type MMTV integration site family, member 10A
img GENERIF, Score=923, Pubmed Id: 18787224, UMLKSK CUI: C0334634
HumanAICDA57379activation-induced cytidine deaminase
img GENERIF, Score=1000, Pubmed Id: 14551145, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 15781912, UMLKSK CUI: C0334634
HumanPBK55872PDZ binding kinase
img NCI, Score=801, Pubmed Id: 14757441, UMLKSK CUI: C0334634
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
img NCI, Score=801, Pubmed Id: 15163014, UMLKSK CUI: C0334634
HumanCHEK211200checkpoint kinase 2
img NCI, Score=801, Pubmed Id: 15020270, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 12393693, UMLKSK CUI: C0334634
HumanMALT110892mucosa associated lymphoid tissue lymphoma translocation gene 1
img NCI, Score=801, Pubmed Id: 14997743, UMLKSK CUI: C0334634
HumanSEMA4D10507sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0334634
HumanTUBGCP310426tubulin, gamma complex associated protein 3
img NCI, Score=801, Pubmed Id: 17236200, UMLKSK CUI: C0334634
img NCI, Score=801, Pubmed Id: 17236200, UMLKSK CUI: C0334634
HumanAPOBEC3B9582apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
img NCI, Score=801, Pubmed Id: 16042692, UMLKSK CUI: C0334634
HumanLITAF9516lipopolysaccharide-induced TNF factor
img NCI, Score=801, Pubmed Id: 16960149, UMLKSK CUI: C0334634
HumanABCG29429ATP-binding cassette, sub-family G (WHITE), member 2
img GENERIF, Score=1000, Pubmed Id: 17701580, UMLKSK CUI: C0334634
HumanBCL108915B-cell CLL/lymphoma 10
Click here to display 8 evidence detail records.
HumanDLEU28847deleted in lymphocytic leukemia 2 (non-protein coding)
img NCI, Score=801, Pubmed Id: 11072235, UMLKSK CUI: C0334634
HumanTNFRSF10A8797tumor necrosis factor receptor superfamily, member 10a
img GENERIF, Score=1000, Pubmed Id: 16217763, UMLKSK CUI: C0334634
HumanNR0B28431nuclear receptor subfamily 0, group B, member 2
img NCI, Score=801, Pubmed Id: 14614518, UMLKSK CUI: C0334634
HumanTCL1A8115T-cell leukemia/lymphoma 1A
img NCI, Score=801, Pubmed Id: 10786666, UMLKSK CUI: C0334634
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 11368435, UMLKSK CUI: C0334634
HumanTTK7272TTK protein kinase
img GENERIF, Score=923, Pubmed Id: 16080195, UMLKSK CUI: C0334634
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 18467333, UMLKSK CUI: C0334634
HumanTOP2A7153topoisomerase (DNA) II alpha 170kDa
img GENERIF, Score=1000, Pubmed Id: 15201855, UMLKSK CUI: C0334634
HumanTERF27014telomeric repeat binding factor 2
img NCI, Score=801, Pubmed Id: 15476325, UMLKSK CUI: C0334634
HumanTAL16886T-cell acute lymphocytic leukemia 1
img NCI, Score=801, Pubmed Id: 11781220, UMLKSK CUI: C0334634
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0334634Lymphoma, Mantle-Cell0self