Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | common variation in the P2Y12 gene predicts restenosis in percutaneous coronary intervention-treated patients |
Human | RETN | 56729 | resistin | Serum resistin may prove to be a useful biological marker for coronary artery disease and restenosis in patients with type 2 diabetes mellitus |
Human | IL1F5 | 26525 | interleukin 36 receptor antagonist | The commnon variants in the IL-1 cluster gene are not associated with incidence of restenosis in patients after PTCA |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | increased leptin and decreased adiponectin levels were present in subjects with restenosis restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Overexpression of hPLA2G7 by adenoviral gene transfer in mice diminished the neointima formation (restenosis) induced by a wire-guided denudation of endothelium of the common left carotid and spontaneous atherosclerosis in aortic roots |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Gene transfer of VEGF during PTCA and stenting shows that intracoronary gene transfer can be performed safely; no differences in restenosis rate or lumen diameter were present after 6-month follow-up, and increased myocardial perfusion was detected These findings indicate that the development of restenosis depends on both complement activation regulated by the MBL2 gene and pathologic processes leading to enhanced production of VEGF and PDGF during the very early postoperative period |
Human | UCP3 | 7352 | uncoupling protein 3 (mitochondrial, proton carrier) | Determination of the genotype for UCP3 may thus contribute to assessment of the genetic risk for recurrent in-stent restenosis |
Human | TP53 | 7157 | tumor protein p53 | TP53 polymorphisms were characterized in a cohort of 779 patients, of whom 342 cases had developed restenosis at six months post PTCA Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | TNF | 7124 | tumor necrosis factor | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | high plasma levels of OPN in patients with a history of percutaneous coronary intervention were associated with the presence of restenosis, suggesting that OPN may play a role in the development of restenosis after percutaneous coronary intervention |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | Adenovirus-mediated gene transfer of superoxide dismutase and catalase reduced oxidative stress, restenosis, collagen accumulation, and inflammation and improved endothelial function after angioplasty |
Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | The periprocedural evaluation of sP-selectin and sE-selectin in peripheral venous blood in patients undergoing elective coronary stenting provides no prognostic information in terms of clinical restenosis prediction |
Human | SELE | 6401 | selectin E | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. Title:The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty.|Association:Y|Conclusion:The 128Arg allele of E-selectin may be related to increased endothelial responses to injury, thereby potentially serving as a risk factor for post-angioplasty restenosis in patients with CAD.The development of restenosis remains a problem in patients with CAD. The Ser128Arg polymorphism of E-selectin was analyzed in 101 (derivation) and 92 (validation) CAD patients. Patients with restenosis (54/101 and 43/92) had a higher frequency of the 128Arg allele (14.81 and 17.44%) than those without (5.32%, p=0.027 and 7.14%, p=0.031). In logistic regression, the 128Arg allele emerged as a predictor of restenosis in both studies (p<0.05). The E-selectin 128Arg allele may serve as a risk factor for the development of restenosis. |
Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis Increased expression in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty |
Human | SCNN1A | 6337 | sodium channel, non-voltage-gated 1 alpha subunit | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | ROS1 | 6098 | c-ros oncogene 1 , receptor tyrosine kinase | the G --> A polymorphism of ROS1 genotype was independently associated with in-stent restenosis in a Japanese population |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | polymorphisms of the PPARg gene are not associated with the incidence of restenosis and adverse clinical events at 30 days or 1 year after coronary artery stenting in patients with diabetes mellitus |
Human | PON2 | 5445 | paraoxonase 2 | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | PON1 | 5444 | paraoxonase 1 | data collected in a cohort of 779 patients of whom 342 had developed restenosis indicate that the common variants for CETP and PON are not associated with incidence of restenosis after PTCA Title:New data on the world distribution of paraoxonase (PON1 Gln 192 --> Arg) gene frequencies|Association:Not Found|Conclusion:The data show a large variability in allele frequencies, and, in particular, that PON1 allele distribution depends on membership to different geographic populations. Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. |
Human | PDE1A | 5136 | phosphodiesterase 1A, calmodulin-dependent | PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis ofcommon complex disease.|Association:Not Found|Conclusion:Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities. Plasminogen activator inhibitor-1 has a role in coronary in-stent restenosis of drug-eluting stents If the effect of oncostatin M on PAI-1 in smooth muscle cells is operative in vivo, it could, via fibrinolysis and proteolysis, be involved in plaque progression, destabilization, thrombus formation, restenosis, and neointima formation |