Human | DUOXA1 | 90527 | dual oxidase maturation factor 1 | Overexpression of ninein and the ninein-like protein NIP induces fragmentation of the Golgi and causes lysosomes to disperse toward the cell periphery |
Human | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | Pulsed-field gel electrophoresis of the mus81Delta mutant revealed an expansion of the rDNA locus depending on RAD52, in addition to fragmentation of Chr XII in the sgs1Deltamus81(ts) mutant at permissive temperature |
Human | GORASP1 | 64689 | golgi reassembly stacking protein 1, 65kDa | the GRASP domain alone of GRASP65 inhibits mitotic fragmentation of the Golgi apparatus |
Human | FIS1 | 51024 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | Changes correlate with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fis1 mutants with different effects on organelle shape and function hFis1 is a bifunctional protein that independently regulates mitochondrial fragmentation and endoplasmic reticulum-mediated apoptosis hFis1 induces mitochondrial fragmentation and perinuclear clustering in a state of calcium homeostasis |
Human | PRKD3 | 23683 | protein kinase D3 | Expression of constitutively activated PKCeta caused Golgi fragmentation |
Human | DHS | 10774 | dehydrated hereditary stomatocytosis | Fragmentation and clumping of deep dermis elastic tissue |
Human | DNM1L | 10059 | dynamin 1-like | Dnregulation of Drp1 delays but does not inhibit apoptosis, suggesting that mitochondrial fragmentation is not a prerequisite for apoptosis fragmentation of depolarized mitochondria depends on a loop involving sustained Ca(2+) rise, activation of calcineurin, and dephosphorylation of Drp1 and its translocation to the organelle Data show that BIK activates recruitment of DRP1 to the surface of the endoplasmic reticulum in intact cells, resulting in mitochondrial fragmentation but little release of cytochrome c to the cytosol |
Human | USO1 | 8615 | USO1 vesicle transport factor | Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation |
Human | SUMO1 | 7341 | small ubiquitin-like modifier 1 | unambiguously show that serine 2 of the endogenous SUMO-1 N-terminal protrusion is phosphorylated in vivo using very high mass accuracy mass spectrometry at both the MS and the MS/MS level and complementary fragmentation techniques |
Human | TOP1 | 7150 | topoisomerase (DNA) I | propose that arsenic trioxide induces topoisomerase I-DNA complexes that participate in chromatin fragmentation and programmed cell death during apoptosis |
Human | SURF4 | 6836 | surfeit 4 | Silencing Surf4 together with ERGIC-53 or silencing the p24 family member p25 induced an identical phenotype characterized by a reduced number of ERGIC clusters and fragmentation of the Golgi apparatus without effect on anterograde transport |
Human | SOD3 | 6649 | superoxide dismutase 3, extracellular | inhibition of oxidative hyaluronan fragmentation probably represents one mechanism by which EC-SOD inhibits inflammation in response to lung injury |
Human | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | MLC2 phosphorylation is regulated by both ROCK and MLC kinase and plays an important role in platelet biogenesis by controlling proplatelet formation and fragmentation |
Human | MAP2K1 | 5604 | mitogen-activated protein kinase kinase 1 | Plk3 may be a key protein kinase mediating MEK1 function in the Golgi fragmentation pathway during cell division |
Human | OPA1 | 4976 | optic atrophy 1 (autosomal dominant) | OPA1 has a role in release of cytochrome c and subsequent mitochondrial fragmentation during apoptosis mitochondrial fragmentation correlates with processing of large isoforms of OPA1 |
Human | MYBL2 | 4605 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | Chromosomal fragmentation and other aberrations, including shorter, thicker chromatids, end-to-end fusion, and loss of a chromatid, suggest that reduced B-Myb activity is also associated with structural chromosomal instability |
Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | Review: Exploring environmental causes of altered ras effects: fragmentation plus integration? |
Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | a structural change in the conformation of anti-GPIIIa49-66 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet fragmentation and aggregate dissolution |
Human | HTN3 | 3347 | histatin 3 | results suggest that the genesis of histatin 3-related peptides, being under the principal action of trypsin-like activities, is probably not a random process but rather follows a sequential fragmentation pathway; cleavage sites are identified |
Human | HSPG2 | 3339 | heparan sulfate proteoglycan 2 | Fragmentation of femoral epiphyses |
Human | DFFA | 1676 | DNA fragmentation factor, 45kDa, alpha polypeptide | Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation |
Human | CKB | 1152 | creatine kinase, brain | GM130 and BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | Results describe the role of carbohydrate moiety of bleomycin-A2 in caspase-3 activation and internucleosomal chromatin fragmentation in apoptosis of laryngeal carcinoma cells |
Human | BAX | 581 | BCL2-associated X protein | inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the fragmentation of the mitochondrial network |
Human | BAK1 | 578 | BCL2-antagonist/killer 1 | inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the fragmentation of the mitochondrial network |