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human : 400
mouse : 2
|Mouse||S100P||6286||S100 calcium binding protein P|
Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells.
|Mouse||MCM7||4176||minichromosome maintenance complex component 7|
Furthermore, E7 induced cervical cancer formation even when the E7-pRb interaction was disrupted by the use of a knock-in mouse carrying an E7-resistant mutant Rb allele. pRb inactivation was necessary but not sufficient for E7 to overcome differentiation-induced or DNA damage-induced cell cycle arrest, and expression patterns of the E2F-responsive genes Mcm7 and cyclin E indicate that other E2F regulators besides pRb are important targets of E7.
We then used our mouse model to identify minichromosome maintenance protein 7 (MCM7), an E2F-induced cellular DNA replication factor, as a novel biomarker for cervical cancer.
Title:Analysis of the entire HLA region in susceptibility for cervical cancer: a comprehensive study.|Association:Not Found|Conclusion:There is an association of the region containing the HLA-DQ and HLA-DR genes with the risk of developing squamous cell carcinoma. An increased risk was observed for carriers of allele 184 at the MICA locus, in particular for homozygotes, suggesting a recessive effect.
active MICA motifs have roles in immune activation in cervical cancer
|Human||CCR2||729230||chemokine (C-C motif) receptor 2|
Title:Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinoma.|Association:Y|Conclusion:These findings suggest that CCR2-64I polymorphism might have a protective role in the evolution from high-grade SIL to ICC.
The CCR-2 64I variant was associated with decreased risk of cervical cancer; homozygote carriers of the 64I variant had an odds ratio of 0.31 (0.12-0.77)
In cervical cancer, CEA and GGT reflected tumor burden, while PLAP showed just the reverse--the highest degree of positivity being present in minimal disease.
Combinations of carcinoembryonic antigen (CEA), gamma glutamyl transpeptidase (GGT), pregnancy-associated macroglobulin (PAM) and placenta-like alkaline phosphatase (PLAP) were studied in groups of patients with ovarian and cervical cancer.
|Human||HES5||388585||hairy and enhancer of split 5 (Drosophila)|
expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia
|Human||SGMS1||259230||sphingomyelin synthase 1|
Data show that sphingomyelin synthases SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively
|Human||PAOX||196743||polyamine oxidase (exo-N4-amino)|
Click here to display 3 evidence detail records.
|Human||ZNF384||171017||zinc finger protein 384|
expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas
|Human||DTX3L||151636||deltex 3-like (Drosophila)|
Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 are associated with cervical cancer
|Human||GIPC3||126326||GIPC PDZ domain containing family, member 3|
GIPC3 mRNA was expressed in cervical cancer cell line HeLa S3, chronic myelogenous leukemia cell line K-562, and melanoma cell line G-361.
|Human||HIST4H4||121504||histone cluster 4, H4|
Furthermore, our data indicate that HiNF-P/H4TF-2 may functionally compensate for HiNF-M/IRF-2 at Site II to regulate histone H4 gene transcription in HeLa S3 cervical carcinoma cells during early S phase.
The human cervical carcinoma, Yumoto, which also induced cachexia in recipiant animals, showed expression of PIF in tumour, serum and urine in control and vehicle-treated mice, but was absent in mice treated with 5-dFUrd.
|Human||KIR3DL3||115653||killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3|
Title:A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.|Association:Not Found|Conclusion:It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia.
|Human||TMEM54||113452||transmembrane protein 54|
Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta-casein.
|Human||NACC1||112939||nucleus accumbens associated 1, BEN and BTB (POZ) domain containing|
NAC-1 may play an important role in cervical carcinomas
|Human||MYLK3||91807||myosin light chain kinase 3|
Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells.
|Human||RBM17||84991||RNA binding motif protein 17|
overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine
Interestingly, this study revealed that overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine, two chemotherapeutic drugs commonly used in cancer.
|Human||INHBE||83729||inhibin, beta E|
By RT-PCR, the expression of specific messenger RNAs (mRNAs) for the inhibin alpha, activin betaA and betaB subunits, and activin receptor type II and type IIB was investigated: 1) in primary cultures of endometrial (stroma and epithelium) or cervical (epithelium) cells from healthy women; and 2) in specimens of endometrial or cervical carcinoma.
|Human||WNT10A||80326||wingless-type MMTV integration site family, member 10A|
In addition to SW480, WNT10A was strongly expressed in HL-60 (promyelocytic leukemia) and Raji (Burkitt;s lymphoma), and WNT6 in HeLa S3 (cervical cancer).
|Human||RNF26||79102||ring finger protein 26|
Our results indicate that a major region of LOH in cervical cancer exists within a 3.6-Mb stretch of DNA on 11q23.3-q24.1 and that somatic mutations in RNF26, USP2, TRIM29, POU2F3, or PPP2R1B probably are not important for cervical carcinogenesis.
|Human||SMYD3||64754||SET and MYND domain containing 3|
SMYD3 plays crucial roles in HeLa cell proliferation and migration/invasion, and that it may be a useful therapeutic target in human cervical carcinomas
|Human||SLC46A2||57864||solute carrier family 46, member 2|
Affected sib-pairs with cervical cancer susceptibility and high mean age at diagnosis show increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to maximum lod-score of 2.74 for TSCOT single nucleotide polymorphisms
|Human||AKR1B10||57016||aldo-keto reductase family 1, member B10 (aldose reductase)|
associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma in cervical cancer but not endometrial cancer
Our findings indicate that treatment with the aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (EBPC), enhances the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells.
|Human||DIABLO||56616||diablo, IAP-binding mitochondrial protein|
Click here to display 9 evidence detail records.