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Genes (402)
Species: human : 400 mouse : 2 | |
Mouse | S100P | 6286 | S100 calcium binding protein P | Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells. | Mouse | MCM7 | 4176 | minichromosome maintenance complex component 7 | We then used our mouse model to identify minichromosome maintenance protein 7 (MCM7), an E2F-induced cellular DNA replication factor, as a novel biomarker for cervical cancer. Furthermore, E7 induced cervical cancer formation even when the E7-pRb interaction was disrupted by the use of a knock-in mouse carrying an E7-resistant mutant Rb allele. pRb inactivation was necessary but not sufficient for E7 to overcome differentiation-induced or DNA damage-induced cell cycle arrest, and expression patterns of the E2F-responsive genes Mcm7 and cyclin E indicate that other E2F regulators besides pRb are important targets of E7. | Human | LOC100507436 | 100507436 | | active MICA motifs have roles in immune activation in cervical cancer Title:Analysis of the entire HLA region in susceptibility for cervical cancer: a comprehensive study.|Association:Not Found|Conclusion:There is an association of the region containing the HLA-DQ and HLA-DR genes with the risk of developing squamous cell carcinoma. An increased risk was observed for carriers of allele 184 at the MICA locus, in particular for homozygotes, suggesting a recessive effect. | Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | The CCR-2 64I variant was associated with decreased risk of cervical cancer; homozygote carriers of the 64I variant had an odds ratio of 0.31 (0.12-0.77) Title:Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinoma.|Association:Y|Conclusion:These findings suggest that CCR2-64I polymorphism might have a protective role in the evolution from high-grade SIL to ICC. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Combinations of carcinoembryonic antigen (CEA), gamma glutamyl transpeptidase (GGT), pregnancy-associated macroglobulin (PAM) and placenta-like alkaline phosphatase (PLAP) were studied in groups of patients with ovarian and cervical cancer. In cervical cancer, CEA and GGT reflected tumor burden, while PLAP showed just the reverse--the highest degree of positivity being present in minimal disease. | Human | HES5 | 388585 | hairy and enhancer of split 5 (Drosophila) | expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia | Human | SGMS1 | 259230 | sphingomyelin synthase 1 | Data show that sphingomyelin synthases SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively | Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | Click here to display 3 evidence detail records. | Human | ZNF384 | 171017 | zinc finger protein 384 | expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas | Human | DTX3L | 151636 | deltex 3-like (Drosophila) | Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 are associated with cervical cancer | Human | GIPC3 | 126326 | GIPC PDZ domain containing family, member 3 | GIPC3 mRNA was expressed in cervical cancer cell line HeLa S3, chronic myelogenous leukemia cell line K-562, and melanoma cell line G-361. | Human | HIST4H4 | 121504 | histone cluster 4, H4 | Furthermore, our data indicate that HiNF-P/H4TF-2 may functionally compensate for HiNF-M/IRF-2 at Site II to regulate histone H4 gene transcription in HeLa S3 cervical carcinoma cells during early S phase. | Human | DCD | 117159 | dermcidin | The human cervical carcinoma, Yumoto, which also induced cachexia in recipiant animals, showed expression of PIF in tumour, serum and urine in control and vehicle-treated mice, but was absent in mice treated with 5-dFUrd. | Human | KIR3DL3 | 115653 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | Title:A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.|Association:Not Found|Conclusion:It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia. | Human | TMEM54 | 113452 | transmembrane protein 54 | Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta-casein. | Human | NACC1 | 112939 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | NAC-1 may play an important role in cervical carcinomas | Human | MYLK3 | 91807 | myosin light chain kinase 3 | Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. | Human | RBM17 | 84991 | RNA binding motif protein 17 | overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine Interestingly, this study revealed that overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine, two chemotherapeutic drugs commonly used in cancer. | Human | INHBE | 83729 | inhibin, beta E | By RT-PCR, the expression of specific messenger RNAs (mRNAs) for the inhibin alpha, activin betaA and betaB subunits, and activin receptor type II and type IIB was investigated: 1) in primary cultures of endometrial (stroma and epithelium) or cervical (epithelium) cells from healthy women; and 2) in specimens of endometrial or cervical carcinoma. | Human | WNT10A | 80326 | wingless-type MMTV integration site family, member 10A | In addition to SW480, WNT10A was strongly expressed in HL-60 (promyelocytic leukemia) and Raji (Burkitt;s lymphoma), and WNT6 in HeLa S3 (cervical cancer). | Human | RNF26 | 79102 | ring finger protein 26 | Our results indicate that a major region of LOH in cervical cancer exists within a 3.6-Mb stretch of DNA on 11q23.3-q24.1 and that somatic mutations in RNF26, USP2, TRIM29, POU2F3, or PPP2R1B probably are not important for cervical carcinogenesis. | Human | SMYD3 | 64754 | SET and MYND domain containing 3 | SMYD3 plays crucial roles in HeLa cell proliferation and migration/invasion, and that it may be a useful therapeutic target in human cervical carcinomas | Human | SLC46A2 | 57864 | solute carrier family 46, member 2 | Affected sib-pairs with cervical cancer susceptibility and high mean age at diagnosis show increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to maximum lod-score of 2.74 for TSCOT single nucleotide polymorphisms | Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Our findings indicate that treatment with the aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (EBPC), enhances the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma in cervical cancer but not endometrial cancer | Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Click here to display 9 evidence detail records. |
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