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Genes (402)
Species: human : 400 mouse : 2 | |
Mouse | S100P | 6286 | S100 calcium binding protein P | Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells. | Mouse | MCM7 | 4176 | minichromosome maintenance complex component 7 | Furthermore, E7 induced cervical cancer formation even when the E7-pRb interaction was disrupted by the use of a knock-in mouse carrying an E7-resistant mutant Rb allele. pRb inactivation was necessary but not sufficient for E7 to overcome differentiation-induced or DNA damage-induced cell cycle arrest, and expression patterns of the E2F-responsive genes Mcm7 and cyclin E indicate that other E2F regulators besides pRb are important targets of E7. We then used our mouse model to identify minichromosome maintenance protein 7 (MCM7), an E2F-induced cellular DNA replication factor, as a novel biomarker for cervical cancer. | Human | LOC100507436 | 100507436 | | active MICA motifs have roles in immune activation in cervical cancer Title:Analysis of the entire HLA region in susceptibility for cervical cancer: a comprehensive study.|Association:Not Found|Conclusion:There is an association of the region containing the HLA-DQ and HLA-DR genes with the risk of developing squamous cell carcinoma. An increased risk was observed for carriers of allele 184 at the MICA locus, in particular for homozygotes, suggesting a recessive effect. | Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | The CCR-2 64I variant was associated with decreased risk of cervical cancer; homozygote carriers of the 64I variant had an odds ratio of 0.31 (0.12-0.77) Title:Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinoma.|Association:Y|Conclusion:These findings suggest that CCR2-64I polymorphism might have a protective role in the evolution from high-grade SIL to ICC. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | In cervical cancer, CEA and GGT reflected tumor burden, while PLAP showed just the reverse--the highest degree of positivity being present in minimal disease. Combinations of carcinoembryonic antigen (CEA), gamma glutamyl transpeptidase (GGT), pregnancy-associated macroglobulin (PAM) and placenta-like alkaline phosphatase (PLAP) were studied in groups of patients with ovarian and cervical cancer. | Human | HES5 | 388585 | hairy and enhancer of split 5 (Drosophila) | expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia | Human | SGMS1 | 259230 | sphingomyelin synthase 1 | Data show that sphingomyelin synthases SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively | Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | Click here to display 3 evidence detail records. | Human | ZNF384 | 171017 | zinc finger protein 384 | expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas | Human | DTX3L | 151636 | deltex 3-like (Drosophila) | Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 are associated with cervical cancer | Human | GIPC3 | 126326 | GIPC PDZ domain containing family, member 3 | GIPC3 mRNA was expressed in cervical cancer cell line HeLa S3, chronic myelogenous leukemia cell line K-562, and melanoma cell line G-361. | Human | HIST4H4 | 121504 | histone cluster 4, H4 | Furthermore, our data indicate that HiNF-P/H4TF-2 may functionally compensate for HiNF-M/IRF-2 at Site II to regulate histone H4 gene transcription in HeLa S3 cervical carcinoma cells during early S phase. | Human | DCD | 117159 | dermcidin | The human cervical carcinoma, Yumoto, which also induced cachexia in recipiant animals, showed expression of PIF in tumour, serum and urine in control and vehicle-treated mice, but was absent in mice treated with 5-dFUrd. | Human | KIR3DL3 | 115653 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | Title:A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.|Association:Not Found|Conclusion:It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia. | Human | TMEM54 | 113452 | transmembrane protein 54 | Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta-casein. | Human | NACC1 | 112939 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | NAC-1 may play an important role in cervical carcinomas | Human | MYLK3 | 91807 | myosin light chain kinase 3 | Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. | Human | RBM17 | 84991 | RNA binding motif protein 17 | overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine Interestingly, this study revealed that overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine, two chemotherapeutic drugs commonly used in cancer. | Human | INHBE | 83729 | inhibin, beta E | By RT-PCR, the expression of specific messenger RNAs (mRNAs) for the inhibin alpha, activin betaA and betaB subunits, and activin receptor type II and type IIB was investigated: 1) in primary cultures of endometrial (stroma and epithelium) or cervical (epithelium) cells from healthy women; and 2) in specimens of endometrial or cervical carcinoma. | Human | WNT10A | 80326 | wingless-type MMTV integration site family, member 10A | In addition to SW480, WNT10A was strongly expressed in HL-60 (promyelocytic leukemia) and Raji (Burkitt;s lymphoma), and WNT6 in HeLa S3 (cervical cancer). | Human | RNF26 | 79102 | ring finger protein 26 | Our results indicate that a major region of LOH in cervical cancer exists within a 3.6-Mb stretch of DNA on 11q23.3-q24.1 and that somatic mutations in RNF26, USP2, TRIM29, POU2F3, or PPP2R1B probably are not important for cervical carcinogenesis. | Human | SMYD3 | 64754 | SET and MYND domain containing 3 | SMYD3 plays crucial roles in HeLa cell proliferation and migration/invasion, and that it may be a useful therapeutic target in human cervical carcinomas | Human | SLC46A2 | 57864 | solute carrier family 46, member 2 | Affected sib-pairs with cervical cancer susceptibility and high mean age at diagnosis show increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to maximum lod-score of 2.74 for TSCOT single nucleotide polymorphisms | Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma in cervical cancer but not endometrial cancer Our findings indicate that treatment with the aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (EBPC), enhances the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. | Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Click here to display 9 evidence detail records. |
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