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Details
Link-It Detail - Disease - Primary Systemic Amyloidosis
Debug Stats
  • ### Total Build Time: 88 ms 21.592 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 354 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 451 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=62 ms Completed: 62 ms rowSize= 15.055 KB
  • CONCEPT_GENES gt=15 ms Completed: 15 ms rowSize= 4.519 KB
  • CONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.162 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Primary Systemic Amyloidosis C0281479
Definition (1)
A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits in various tissues and forms a beta-pleated sheet structure that binds Congo red dye with characteristic birefringence. The sites of involvement include heart, liver, kidney, gut, tongue, nerves, and bone. (WHO, 2001)
Relationships (32)

Relation Types:
diso_​to_​anat : 18
diso_​to_​diso : 13
diso_​to_​phen : 1


Relationships:
clinically_​similar : 1
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 5
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​normal_​cell_​origin_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 1
may_​be_​associated_​disease_​of_​disease : 6
may_​be_​finding_​of_​disease : 2
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg B lymphoblast C1516097
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B-Lymphocytes C0004561
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Lymphatic Tissue C0024296
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Lymphocyte C0024264
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Mature B-Cell C1513019
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Myeloid Cells C0887899
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic B-Lymphocyte C1513929
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Lymphocyte C1514011
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Plasma Cell C1514058
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Plasma Cells C0032112
DISO_to_DISOis_finding_of_diseaseimg Amorphus, Eosinophilic, and Acellular Deposit C1705760
DISO_to_DISOis_finding_of_diseaseimg Apple Green Dichromism Present in Polarized Congo-Red Stained Sections C1706838
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Congestive heart failure C0018802
DISO_to_DISOmay_be_finding_of_diseaseimg Enlarged Liver C0019209
DISO_to_DISOis_finding_of_diseaseimg Immunoglobulin Deposition C1512663
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Kidney Failure C0035078
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Malabsorption Syndrome C0024523
Genes (4)

Species:
human : 4
SpeciesGeneGeneIdGene NameEvidence
HumanTNFRSF1A7132tumor necrosis factor receptor superfamily, member 1A
img OMIM, Score=1000, UMLKSK CUI: C0281479
HumanLYZ4069lysozyme
img GENERIF, Score=913, Pubmed Id: 16329101, UMLKSK CUI: C0281479
HumanFGA2243fibrinogen alpha chain
img GENERIF, Score=901, Pubmed Id: 16468976, UMLKSK CUI: C0281479
HumanAPOA1335apolipoprotein A-I
img GENERIF, Score=1000, Pubmed Id: 12421824, UMLKSK CUI: C0281479
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0281479Primary Systemic Amyloidosis0self