GATACA

Credits

Hide Credits

Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Adenocarcinoma of Pancreas

Debug Stats

### Total Build Time: 27 ms 36.601 KB
CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 350 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 307 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
CONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 34.625 KB
CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.160 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Adenocarcinoma of Pancreas C0281361

Definition (1)

An adenocarcinoma which arises from the exocrine pancreas. Ductal adenocarcinoma and its variants are the most common types of pancreatic adenocarcinoma.

Genes (173)

Species:

human : 169

mouse : 4

Page Size

Current 25

100

250

ALL

Page 1 of 7

Prior Page

Current 1

Species	Gene	GeneId	Gene Name	Evidence
Mouse	PTK2	5747	protein tyrosine kinase 2	NCI, Score=801, Pubmed Id: 15118593, UMLKSK CUI: C0281361 CONCLUSION: FAK gene silencing suppresses anoikis resistance in pancreatic adenocarcinoma cells.
Mouse	CEACAM6	4680	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	NCI, Score=801, Pubmed Id: 15081416, UMLKSK CUI: C0281361 Using pancreatic adenocarcinoma as a model, we show that crosslinking CEACAM6 induces its cytoplasmic accumulation and that this effect can be utilized to increase the efficacy of antibody-mediated delivery of the ribosomal inhibitory protein saporin.
Mouse	IGF1R	3480	insulin-like growth factor 1 receptor	NCI, Score=801, Pubmed Id: 10640145, UMLKSK CUI: C0281361 DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma.
Mouse	FGF1	2246	fibroblast growth factor 1 (acidic)	NCI, Score=801, Pubmed Id: 11316575, UMLKSK CUI: C0281361 These results suggest an interdependent role between FGF-1 and ONOO(-) during the development and progression of pancreatic adenocarcinoma.
Human	GGT2	728441	gamma-glutamyltransferase 2	NCI, Score=801, Pubmed Id: 10088549, UMLKSK CUI: C0281361 These included renal cell carcinomas, hepatocellular and cholangiocarcinomas, and carcinomas of the prostate and thyroid whereas both pancreatic adenocarcinomas and infiltrating carcinomas of the breast showed a wide range of GGT expression.
Human	SARNP	84324	SAP domain containing ribonucleoprotein	NCI, Score=801, Pubmed Id: 11356193, UMLKSK CUI: C0281361 Hcc-1 cDNA level was increased in pancreatic adenocarcinoma.
Human	CDC73	79577	cell division cycle 73	OMIM, Score=1000, UMLKSK CUI: C0281361 Pancreatic adenocarcinoma
Human	HHIP	64399	hedgehog interacting protein	NCI, Score=801, Pubmed Id: 15970691, UMLKSK CUI: C0281361 These results indicate in some pancreatic adenocarcinomas that HHIP is epigenetically inactivated by promoter methylation, and its silencing could contribute to the increased Hedgehog signaling observed in pancreatic neoplasms.
Human	MUC3B	57876	mucin 3B, cell surface associated	NCI, Score=801, Pubmed Id: 12657964, UMLKSK CUI: C0281361 CONCLUSION: Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.
Human	FBXW7	55294	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	NCI, Score=801, Pubmed Id: 14507635, UMLKSK CUI: C0281361 Both BRAF and FBXW7 mutations functionally activate kinase effectors important in pancreatic cancer and extend the potential options for therapeutic targeting of kinases in the treatment of phenotypically distinct pancreatic adenocarcinoma subsets. GENERIF, Score=861, Pubmed Id: 14507635, UMLKSK CUI: C0281361 Both BRAF and FBXW7 mutations functionally activate kinase effectors important in pancreatic cancer and extend the potential options for therapeutic targeting of kinases in the treatment of phenotypically distinct pancreatic adenocarcinoma subsets NCI, Score=801, Pubmed Id: 14507635, UMLKSK CUI: C0281361 Both BRAF and FBXW7 mutations functionally activate kinase effectors important in pancreatic cancer and extend the potential options for therapeutic targeting of kinases in the treatment of phenotypically distinct pancreatic adenocarcinoma subsets.
Human	LUZP4	51213	leucine zipper protein 4	NCI, Score=801, Pubmed Id: 14991579, UMLKSK CUI: C0281361 In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Human	LSM1	27257	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	NCI, Score=801, Pubmed Id: 15727932, UMLKSK CUI: C0281361 Establishing a Murine Pancreatic Cancer CaSm Model: Up-regulation of CaSm Is Required for the Transformed Phenotype of Murine Pancreatic Adenocarcinoma. NCI, Score=801, Pubmed Id: 15727932, UMLKSK CUI: C0281361 We have recently shown that the cancer-associated Sm-like protein (CaSm) is overexpressed in human pancreatic adenocarcinoma (PC).
Human	CADM1	23705	cell adhesion molecule 1	Click here to display 5 evidence detail records.
Human	AMACR	23600	alpha-methylacyl-CoA racemase	NCI, Score=801, Pubmed Id: 15725808, UMLKSK CUI: C0281361 Although p63 and AMACR are also specific for pancreatic adenocarcinoma, their low sensitivity limits their use in clinical practice.
Human	RPL13A	23521	ribosomal protein L13a	NCI, Score=801, Pubmed Id: 11704875, UMLKSK CUI: C0281361 Furthermore, we found dysregulated expression of genes not previously associated with pancreatic adenocarcinoma, such as Rac 1, GLG1, NEDD5, RPL-13a, RPS9 and members of the Wnt5A gene family.
Human	CES3	23491	carboxylesterase 3	NCI, Score=801, Pubmed Id: 12168825, UMLKSK CUI: C0281361 Except for lung and ovarian carcinoma, the BR-3 gene is expressed in breast carcinoma, colon adenocarcinoma, prostatic adenocarcinoma, and pancreatic adenocarcinoma tissue samples.
Human	PALLD	23022	palladin, cytoskeletal associated protein	GENERIF, Score=1000, Pubmed Id: 17228136, UMLKSK CUI: C0281361 Palladin RNA was overexpressed in the tissues from precancerous dysplasia and pancreatic adenocarcinoma in both the familial and the sporadic disease
Human	KLRK1	22914	killer cell lectin-like receptor subfamily K, member 1	GENERIF, Score=966, Pubmed Id: 17635809, UMLKSK CUI: C0281361 Results indicate for the first time that the NKG2D pathway is involved in the lysis of different melanomas, pancreatic adenocarcinomas, squamous cell carcinomas of the head and neck, and lung carcinoma
Human	PTPRT	11122	protein tyrosine phosphatase, receptor type, T	NCI, Score=801, Pubmed Id: 12501215, UMLKSK CUI: C0281361 We have previously identified a human receptor protein tyrosine phosphatase of the MAM domain family, termed PCP-2, in human pancreatic adenocarcinoma cells and found that this protein was colocalized with beta-catenin and E-cadherin at cell junctions [Wang, H.-Y., et al.
Human	OGFR	11054	opioid growth factor receptor	NCI, Score=801, Pubmed Id: 10601579, UMLKSK CUI: C0281361 Identification and characterization of opioid growth factor receptor in human pancreatic adenocarcinoma.
Human	HSPH1	10808	heat shock 105kDa/110kDa protein 1	NCI, Score=801, Pubmed Id: 14534695, UMLKSK CUI: C0281361 During immunohistochemical studies, we discovered that overexpression of hsp105 occurred not only in cases of colorectal and pancreatic adenocarcinoma, but also thyroid, esophageal, breast, and bladder carcinoma and islet cell tumor, gastric malignant lymphoma, pheochromocytoma, and seminoma. NCI, Score=801, Pubmed Id: 14534695, UMLKSK CUI: C0281361 We earlier reported that heat shock protein 105 (hsp105), which we identified by serological analyses of recombinant cDNA expression libraries (SEREX), was overexpressed in human colon and pancreatic adenocarcinoma.
Human	IGF2BP3	10643	insulin-like growth factor 2 mRNA binding protein 3	GENERIF, Score=1000, Pubmed Id: 18499984, UMLKSK CUI: C0281361 IMP3 is a promising new marker with high specificity and sensitivity for pancreatic adenocarcinoma
Human	TCIRG1	10312	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	NCI, Score=801, Pubmed Id: 10329006, UMLKSK CUI: C0281361 TIRC7 and OC116, a recently described putative subunit of the vacuolar proton pump that was demonstrated to be expressed in an osteoclastoma tumor as well as in a human pancreatic adenocarcinoma cell line, are demonstrated to be alternative transcripts of the same gene.
Human	MSLN	10232	mesothelin	Click here to display 14 evidence detail records.
Human	THOC1	9984	THO complex 1	NCI, Score=801, Pubmed Id: 16465385, UMLKSK CUI: C0281361 Combination gene therapy with p53 and Thoc1/p84 is more effective than either single agent in an animal model of human pancreatic adenocarcinoma. NCI, Score=801, Pubmed Id: 16465385, UMLKSK CUI: C0281361 We have tested whether combination therapy with Thoc1/p84 and p53 is more effective than single gene therapy in a p53-resistant tumor model of human pancreatic adenocarcinoma.

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0281361	Adenocarcinoma of Pancreas	0		self

Gataca is supported by...