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Details
Link-It Detail - Disease - Diffuse Astrocytoma
Debug Stats
  • ### Total Build Time: 22 ms 43.393 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 336 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 678 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=17 ms Completed: 17 ms rowSize= 41.075 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Diffuse Astrocytoma C0280785
Definition (1)
A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures. These lesions typically affect young adults and have an intrinsic tendency for malignant progression to anaplastic astrocytoma and, ultimately, glioblastoma. According to the prevailing cells type, three major variants can be distinguished: fibrillary astrocytoma, gemistocytic astrocytoma, and protoplasmic astrocytoma. (Adapted from WHO)
Genes (40)

Species:
human : 40
Page Size
Current 25
  Page 1 of 2
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanSOX655553SRY (sex determining region Y)-box 6
img NCI, Score=801, Pubmed Id: 15696967, UMLKSK CUI: C0280785
HumanADAM2810863ADAM metallopeptidase domain 28
img NCI, Score=801, Pubmed Id: 15862898, UMLKSK CUI: C0280785
HumanOLIG210215oligodendrocyte lineage transcription factor 2
img NCI, Score=801, Pubmed Id: 14730454, UMLKSK CUI: C0280785
HumanTNFRSF6B8771tumor necrosis factor receptor superfamily, member 6b, decoy
img NCI, Score=801, Pubmed Id: 11289159, UMLKSK CUI: C0280785
HumanHRK8739harakiri, BCL2 interacting protein (contains only BH3 domain)
img NCI, Score=801, Pubmed Id: 16155764, UMLKSK CUI: C0280785
HumanTXN7295thioredoxin
img NCI, Score=801, Pubmed Id: 12744469, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 12744469, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 12744469, UMLKSK CUI: C0280785
HumanTOP2A7153topoisomerase (DNA) II alpha 170kDa
img NCI, Score=801, Pubmed Id: 12937144, UMLKSK CUI: C0280785
HumanTERC7012telomerase RNA component
img NCI, Score=801, Pubmed Id: 9094971, UMLKSK CUI: C0280785
HumanTCF126938transcription factor 12
img NCI, Score=801, Pubmed Id: 14730454, UMLKSK CUI: C0280785
HumanTCF36929transcription factor 3
img NCI, Score=801, Pubmed Id: 14730454, UMLKSK CUI: C0280785
HumanSYP6855synaptophysin
img NCI, Score=801, Pubmed Id: 11922706, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 11484825, UMLKSK CUI: C0280785
HumanSOD26648superoxide dismutase 2, mitochondrial
img NCI, Score=801, Pubmed Id: 12744469, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 12744469, UMLKSK CUI: C0280785
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 16868662, UMLKSK CUI: C0280785
HumanPAX55079paired box 5
img NCI, Score=801, Pubmed Id: 8521821, UMLKSK CUI: C0280785
HumanNME44833NME/NM23 nucleoside diphosphate kinase 4
img NCI, Score=801, Pubmed Id: 11156382, UMLKSK CUI: C0280785
HumanNME34832NME/NM23 nucleoside diphosphate kinase 3
img NCI, Score=801, Pubmed Id: 11156382, UMLKSK CUI: C0280785
HumanNME14830NME/NM23 nucleoside diphosphate kinase 1
img NCI, Score=801, Pubmed Id: 17057884, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 17057884, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 17057884, UMLKSK CUI: C0280785
HumanMGMT4255O-6-methylguanine-DNA methyltransferase
img GENERIF, Score=1000, Pubmed Id: 17965865, UMLKSK CUI: C0280785
HumanMCM34172minichromosome maintenance complex component 3
img NCI, Score=801, Pubmed Id: 15671553, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 15671553, UMLKSK CUI: C0280785
HumanMCM24171minichromosome maintenance complex component 2
img NCI, Score=801, Pubmed Id: 16150117, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 16150117, UMLKSK CUI: C0280785
HumanMAP24133microtubule-associated protein 2
img NCI, Score=801, Pubmed Id: 15034726, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 11922706, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 11922706, UMLKSK CUI: C0280785
HumanIGFBP43487insulin-like growth factor binding protein 4
img NCI, Score=801, Pubmed Id: 12937144, UMLKSK CUI: C0280785
HumanIGFBP23485insulin-like growth factor binding protein 2, 36kDa
img NCI, Score=801, Pubmed Id: 11118044, UMLKSK CUI: C0280785
HumanIDH13417isocitrate dehydrogenase 1 (NADP+), soluble
img GENERIF, Score=1000, Pubmed Id: 18985363, UMLKSK CUI: C0280785
HumanHIF1A3091hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
img NCI, Score=801, Pubmed Id: 15175080, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 15175080, UMLKSK CUI: C0280785
img GENERIF, Score=1000, Pubmed Id: 15175080, UMLKSK CUI: C0280785
img NCI, Score=801, Pubmed Id: 15175080, UMLKSK CUI: C0280785
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0280785Diffuse Astrocytoma0self