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Details
Link-It Detail - Disease - Laryngeal Squamous Cell Carcinoma
Debug Stats
  • ### Total Build Time: 180 ms 59.307 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 364 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 778 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=122 ms Completed: 122 ms rowSize= 15.570 KB
  • CONCEPT_GENES gt=45 ms Completed: 45 ms rowSize= 41.384 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.167 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Laryngeal Squamous Cell Carcinoma C0280324
Definition (1)
A squamous cell carcinoma arising from the larynx. It is the most common type of laryngeal carcinoma. The site of origin within the larynx influences the symptoms, histologic characteristics, and clinical behavior of squamous cell carcinoma. The laryngeal squamous cell carcinomas can be glottic, supraglottic, and transglottic. Glottic carcinoma is the most frequent form of laryngeal carcinoma in the United States. Microscopically, squamous cell carcinomas of the larynx are similar in their appearance to squamous cell carcinomas arising elsewhere (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999).
Relationships (50)

Relation Types:
diso_​to_​anat : 17
diso_​to_​chem : 1
diso_​to_​diso : 30
diso_​to_​gene : 2


Relationships:
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 3
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 14
may_​be_​cytogenetic_​abnormality_​of_​disease : 12
may_​be_​molecular_​abnormality_​of_​disease : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Anterior portion of neck C0230069
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelium, Laryngeal C0751258
DISO_to_ANATis_associated_anatomic_site_ofimg Head and neck structure C0460004
DISO_to_ANATis_associated_anatomic_site_ofimg Larynx C0023078
DISO_to_ANATis_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Neck C0027530
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Glandular Cell C1513973
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Squamous Cell C1514101
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Squamous Cell C0221910
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg Cyclin B1 C0385333
DISO_to_DISOis_finding_of_diseaseimg Carcinomatous Component Present C1707292
DISO_to_DISOisaimg Epidermoid Carcinoma in situ of Larynx C1336090
DISO_to_DISOisaimg Epidermoid Carcinoma of Glottis C0280325
DISO_to_DISOisaimg Epidermoid Carcinoma of Subglottis C0280326
DISO_to_DISOisaimg Epidermoid Carcinoma of Supraglottis C0749163
DISO_to_DISOis_finding_of_diseaseimg Epithelial Component Present C1707933
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Gain of Chromosome 11q13 C1708165
Genes (58)

Species:
human : 57
mouse : 1
Page Size
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SpeciesGeneGeneIdGene NameEvidence
MouseLY6D8581lymphocyte antigen 6 complex, locus D
img NCI, Score=801, Pubmed Id: 2297047, UMLKSK CUI: C0280324
HumanLGALS7B653499lectin, galactoside-binding, soluble, 7B
img GENERIF, Score=988, Pubmed Id: 18315601, UMLKSK CUI: C0280324
HumanH19283120H19, imprinted maternally expressed transcript (non-protein coding)
img GENERIF, Score=1000, Pubmed Id: 18604514, UMLKSK CUI: C0280324
HumanMAGEC3139081melanoma antigen family C, 3
img NCI, Score=801, Pubmed Id: 10564583, UMLKSK CUI: C0280324
HumanBMF90427Bcl2 modifying factor
img GENERIF, Score=1000, Pubmed Id: 17557568, UMLKSK CUI: C0280324
HumanBCL2L1479370BCL2-like 14 (apoptosis facilitator)
img GENERIF, Score=1000, Pubmed Id: 17557568, UMLKSK CUI: C0280324
HumanCOPS510987COP9 signalosome subunit 5
img NCI, Score=801, Pubmed Id: 15671554, UMLKSK CUI: C0280324
img GENERIF, Score=988, Pubmed Id: 15671554, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 15671554, UMLKSK CUI: C0280324
HumanMSLN10232mesothelin
img NCI, Score=801, Pubmed Id: 11848542, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 11848542, UMLKSK CUI: C0280324
HumanPTGES9536prostaglandin E synthase
img NCI, Score=801, Pubmed Id: 16720448, UMLKSK CUI: C0280324
HumanBCL108915B-cell CLL/lymphoma 10
img NCI, Score=801, Pubmed Id: 12389689, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12389689, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12389689, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12389689, UMLKSK CUI: C0280324
HumanTNFRSF10D8793tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
img NCI, Score=801, Pubmed Id: 17357513, UMLKSK CUI: C0280324
HumanTP638626tumor protein p63
img GENERIF, Score=988, Pubmed Id: 12379767, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12379767, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12379767, UMLKSK CUI: C0280324
HumanLY6D8581lymphocyte antigen 6 complex, locus D
img NCI, Score=801, Pubmed Id: 2297047, UMLKSK CUI: C0280324
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 18509272, UMLKSK CUI: C0280324
HumanTOP2A7153topoisomerase (DNA) II alpha 170kDa
img GENERIF, Score=1000, Pubmed Id: 19019771, UMLKSK CUI: C0280324
HumanTIMP17076TIMP metallopeptidase inhibitor 1
img NCI, Score=801, Pubmed Id: 12739032, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 9758368, UMLKSK CUI: C0280324
HumanSPP16696secreted phosphoprotein 1
img GENERIF, Score=926, Pubmed Id: 16299231, UMLKSK CUI: C0280324
HumanHLTF6596helicase-like transcription factor
img GENERIF, Score=988, Pubmed Id: 18825407, UMLKSK CUI: C0280324
HumanSLC3A26520solute carrier family 3 (amino acid transporter heavy chain), member 2
img NCI, Score=801, Pubmed Id: 2208000, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 2208000, UMLKSK CUI: C0280324
HumanSKP26502S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
img NCI, Score=801, Pubmed Id: 16075976, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12579266, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 16075976, UMLKSK CUI: C0280324
img GENERIF, Score=988, Pubmed Id: 12579266, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 12579266, UMLKSK CUI: C0280324
HumanS100A26273S100 calcium binding protein A2
img NCI, Score=801, Pubmed Id: 10956408, UMLKSK CUI: C0280324
img NCI, Score=801, Pubmed Id: 10956408, UMLKSK CUI: C0280324
HumanRB15925retinoblastoma 1
img GENERIF, Score=1000, Pubmed Id: 12377414, UMLKSK CUI: C0280324
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 18027256, UMLKSK CUI: C0280324
HumanSERPINB55268serpin peptidase inhibitor, clade B (ovalbumin), member 5
img GENERIF, Score=1000, Pubmed Id: 18236066, UMLKSK CUI: C0280324
HumanNME14830NME/NM23 nucleoside diphosphate kinase 1
Click here to display 11 evidence detail records.
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0280324Laryngeal Squamous Cell Carcinoma0self