Genes (58)
Species: human : 57 mouse : 1 | |
Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | After immunization of mice with viable cells of a metastasis of a laryngeal squamous cell carcinoma, a monoclonal antibody E 48 was obtained that detects an epitope present exclusively in squamous and transitional epithelium and their neoplastic counterparts. | Human | LGALS7B | 653499 | lectin, galactoside-binding, soluble, 7B | An association was seen between the level of presence of galectins-1 and -7 and neoplastic progression of hypopharyngeal and laryngeal squamous cell carcinomas | Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | Results decribethe loss IGF2/H19 imprinting,loss of heterozygosity of IGF2R and CTCF, and incidental H. pylori infections in laryngeal squamous cell carcinoma | Human | MAGEC3 | 139081 | melanoma antigen family C, 3 | HLA class I and beta-2-microglobulin (beta2m) expression in a moderately differentiated laryngeal squamous cell carcinoma appeared to be downregulated when analyzed by immunohistochemical procedures using the monomorphic anti-HLA class I monoclonal antibody (mAb; W6/32), locus-specific (HCA2 and HC10) and allele-specific (LT129.11 and KRE501) mAbs and anti-beta2m mAbs. | Human | BMF | 90427 | Bcl2 modifying factor | data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma | Human | BCL2L14 | 79370 | BCL2-like 14 (apoptosis facilitator) | data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | Prognostic significance of jab1 expression in laryngeal squamous cell carcinomas. The purpose of this study is to investigate whether Jab1 expression is correlated with p27(kip1) level and cell proliferation, as well as whether Jab1 expression is associated with clinicopathologic variables and prognosis of laryngeal squamous cell carcinoma (LSCC).EXPERIMENTAL DESIGN: Immunohistochemical and/or Western blot analysis was done in HEp-2 cells and 102 cases of LSCCs.RESULTS: Jab1 expression was negatively associated with p27(kip1) expression and was positively associated with cell proliferation both in HEp-2 cells and LSCCs. Jab1 protein may contribute to the tumor progression in laryngeal squamous cell carcinomas | Human | MSLN | 10232 | mesothelin | With the aim of identifying tumor-associated antigens that could be potential markers and/or targets of diagnostic and/or therapeutic approaches, we studied the occurrence of circulating IgG antibodies to human stromelysin-3, collagenase-3, galectin-3 and mesothelin, by Western blot against their purified recombinant forms, in the sera of 50 patients with pharynx/larynx squamous cell carcinoma (PLSCC), as well as in the sera of 50 healthy blood donors. Circulating IgG response to stromelysin-3, collagenase-3, galectin-3 and mesothelin in patients with pharynx/larynx squamous cell carcinoma. | Human | PTGES | 9536 | prostaglandin E synthase | Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. | Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | To define the frequency of Bcl10 mutations in laryngeal squamous cell carcinoma and their possible association with tumour progression, we investigated a large panel of tumours representative of all grades and stages of malignancy. Lack of Bcl10 gene mutations in laryngeal squamous cell carcinoma. To define the frequency of Bcl10 mutations in laryngeal squamous cell carcinoma and their possible association with tumour progression, we investigated a large panel of tumours representative of all grades and stages of malignancy. Lack of Bcl10 gene mutations in laryngeal squamous cell carcinoma. | Human | TNFRSF10D | 8793 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | [The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma] OBJECTIVE: To study the expression of tumor necrosis factor related apoptosis induce ligand (TRAIL) receptors (DR4, DR5, DcR1, DcR2) in human laryngeal squamous cell carcinoma(LSCC). | Human | TP63 | 8626 | tumor protein p63 | p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity. We evaluated for the first time the prevalence and clinical implications of p63 immunoreactivity (IR) and mRNA expression in laryngeal squamous cell carcinomas (LSCCs). prevalence and clinical implications of p63 immunoreactivity (IR) and mRNA expression in laryngeal squamous cell carcinomas | Human | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | After immunization of mice with viable cells of a metastasis of a laryngeal squamous cell carcinoma, a monoclonal antibody E 48 was obtained that detects an epitope present exclusively in squamous and transitional epithelium and their neoplastic counterparts. | Human | TP53 | 7157 | tumor protein p53 | A possible correlation between overexpression of p53, proliferating cell nuclear antigen (PCNA), and c-erbB-2, and the clinicopathologic features of laryngeal squamous cell carcinoma, was investigated | Human | TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | findings suggest that high Topo II-alpha expression may be a useful indicator of tumor aggressiveness and poor outcome in laryngeal squamous cell carcinoma | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | In this study, immunohistochemical staining for MMP-1, TIMP-1, and Type I collagen was performed on paraffin-embedded sections from 83 laryngeal squamous cell carcinomas. Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas. | Human | SPP1 | 6696 | secreted phosphoprotein 1 | Results identify osteopontin as a marker and a potential therapeutic target in cases of aggressive laryngeal squamous cell carcinomas | Human | HLTF | 6596 | helicase-like transcription factor | There is an association between the presence of helicase-like transcription factor and neoplastic progression of hypopharyngeal and laryngeal squamous cell carcinomas | Human | SLC3A2 | 6520 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | Relationship of 4F2 antigen with local growth and metastatic potential of squamous cell carcinoma of the larynx. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-node metastases, corresponding to six primary tumors, for 4F2 expression. | Human | SKP2 | 6502 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications. S-phase kinase-associated protein 2 overexpression is associated with laryngeal squamous cell carcinomas [Expression of Skp2 and p27 proteins in laryngeal squamous cell carcinoma and their significances] OBJECTIVE: To investigate the expression of Skp2 and p27 and their association with clinical, histologic characteristics and prognosis in laryngeal squamous cell carcinoma (LSCC), the correlation between expression of Skp2 and p27 in LSCC. However, the clinical significance of Skp2 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. | Human | S100A2 | 6273 | S100 calcium binding protein A2 | Prognostic significance of the Ca(2+) binding protein S100A2 in laryngeal squamous-cell carcinoma. We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). | Human | RB1 | 5925 | retinoblastoma 1 | Gene aberrations at chromosome 13 are involved in the progression of laryngeal squamous cell carcinoma; results provided further evidence for the putative role of the RB1 gene alterations in the metastatic process | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | There was a statistically significant correlation between COX-2 immunoreactivity and the cytoplasmic HuR expression level in laryngeal squamous cell carcinoma | Human | SERPINB5 | 5268 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | MASPIN nuclear location was not a good prognostic factor in laryngeal squamous cell carcinoma | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Click here to display 11 evidence detail records. |
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