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Details
Link-It Detail - Disease - Epidermoid Carcinoma of Oropharynx
Debug Stats
  • ### Total Build Time: 19 ms 28.532 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 366 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1,010 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=7 ms Completed: 7 ms rowSize= 14.187 KB
  • CONCEPT_GENES gt=6 ms Completed: 6 ms rowSize= 11.764 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.168 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Epidermoid Carcinoma of Oropharynx C0280313
Definition (1)
A squamous cell carcinoma arising from the oropharynx. It predominantly affects adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with locally advanced disease. Signs and symptoms include mucosal ulceration, pain, bleeding, weight loss, neck swelling, and difficulty speaking, chewing, and swallowing. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.
Relationships (31)

Relation Types:
diso_​to_​anat : 18
diso_​to_​diso : 13


Relationships:
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 3
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 3
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 10
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Anterior portion of neck C0230069
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelium of oropharynx C1179158
DISO_to_ANATis_associated_anatomic_site_ofimg Head and neck structure C0460004
DISO_to_ANATis_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Neck C0027530
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Glandular Cell C1513973
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Squamous Cell C1514101
DISO_to_ANATis_associated_anatomic_site_ofimg Oropharyngeal C0521367
DISO_to_ANATis_associated_anatomic_site_ofimg Pharyngeal structure C0031354
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Squamous Cell C0221910
DISO_to_DISOis_finding_of_diseaseimg Carcinomatous Component Present C1707292
DISO_to_DISOisaimg Epidermoid Carcinoma in situ of Oropharynx C0861725
DISO_to_DISOis_finding_of_diseaseimg Epithelial Component Present C1707933
DISO_to_DISOisaimg HPV-Associated Oropharyngeal Squamous Cell Carcinoma C2828150
DISO_to_DISOis_not_finding_of_diseaseimg Mixed Neoplastic Glandular and Squamous Cell Population C1881876
DISO_to_DISOisaimg Recurrent Epidermoid Carcinoma of Oropharynx C0280376
DISO_to_DISOisaimg SCC of Soft Palate C0747154
Genes (10)

Species:
human : 10
SpeciesGeneGeneIdGene NameEvidence
HumanCSMD164478CUB and Sushi multiple domains 1
img GENERIF, Score=1000, Pubmed Id: 12696061, UMLKSK CUI: C0280313
HumanTP537157tumor protein p53
img GENERIF, Score=937, Pubmed Id: 14759115, UMLKSK CUI: C0280313
HumanRAP1GAP5909RAP1 GTPase activating protein
img GENERIF, Score=1000, Pubmed Id: 16436672, UMLKSK CUI: C0280313
HumanMMP194327matrix metallopeptidase 19
img GENERIF, Score=1000, Pubmed Id: 18161657, UMLKSK CUI: C0280313
HumanJUP3728junction plakoglobin
img NCI, Score=801, Pubmed Id: 11271788, UMLKSK CUI: C0280313
HumanGALR12587galanin receptor 1
img NCI, Score=801, Pubmed Id: 15767248, UMLKSK CUI: C0280313
img NCI, Score=801, Pubmed Id: 15767248, UMLKSK CUI: C0280313
HumanERBB22064v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
img GENERIF, Score=1000, Pubmed Id: 11839675, UMLKSK CUI: C0280313
HumanCST61474cystatin E/M
img NCI, Score=801, Pubmed Id: 12798398, UMLKSK CUI: C0280313
HumanCCR71236chemokine (C-C motif) receptor 7
img GENERIF, Score=988, Pubmed Id: 16223574, UMLKSK CUI: C0280313
HumanCCND1595cyclin D1
img GENERIF, Score=937, Pubmed Id: 14759115, UMLKSK CUI: C0280313
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0280313Epidermoid Carcinoma of Oropharynx0self