Human | PRDM16 | 63976 | PR domain containing 16 | structure, expression pattern, and function of MEL1 in leukemia cells; overexpression of the zinc finger protein lacking the PR domain (EVI1 and MEL1S)is likely one of the causative factors in the pathogenesis of myeloid leukemia |
Human | SETD8P1 | 57108 | SET domain containing 8 pseudogene 1 | Results support the hypothesis that methylation of H4 lysine 20 by PR/Set7 maintains silent chromatin, in part, by precluding neighboring acetylation on the H4 tail |
Human | WWOX | 51741 | WW domain containing oxidoreductase | Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response |
Human | TBX21 | 30009 | T-box 21 | The expression patterns of T-Bet and GATA-3 oppose progesteron receptor, suggesting antagonistic function and/or regulation between PR and T-Bet/GATA-3 |
Human | PRDM2 | 7799 | PR domain containing 2, with ZNF domain | Tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers |
Human | XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | The snp XRCC2 rs3218536 showd some evidence of a protective association for the rare allele in progesterone receptor positive breast neoplasms |
Human | TFAP2C | 7022 | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response |
Human | STAT5A | 6776 | signal transducer and activator of transcription 5A | a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene |
Human | SOX9 | 6662 | SRY (sex determining region Y)-box 9 | These findings suggest that non-syndromic PRS may be caused by both SOX9 and KCNJ2 dysregulation |
Human | PGR | 5241 | progesterone receptor | Click here to display 39 evidence detail records. |
Human | NR3C2 | 4306 | nuclear receptor subfamily 3, group C, member 2 | glucocorticoid and mineralocorticoid cross-talk with PR to produce progesterone-like effects in breast cancer cells |
Human | HDAC2 | 3066 | histone deacetylase 2 | depletion of HDAC2 results in simultaneous depletion of ER and PR, and potentiates the effects of antihormonal therapy in ER-positive cells |
Human | NR3C1 | 2908 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene |
Human | GPER | 2852 | | GPR30 expression is downregulated in infiltrating ductal carcinoma of the breast; GPR30 is preferentially co-expressed with ER and/or PR but is lowly expressed in HER-2/neu(+) tumors |
Human | GATA3 | 2625 | GATA binding protein 3 | The expression patterns of T-Bet and GATA-3 oppose progesterone receptor, suggesting antagonistic function and/or regulation between PR and T-Bet/GATA-3 |
Human | FKBP4 | 2288 | FK506 binding protein 4, 59kDa | FKBP52 is an essential regulator of PR-A action in the uterus |
Human | ESR1 | 2099 | estrogen receptor 1 | Most adult granulosa cell tumors and Sertoli-Leydig cell tumors share overlapping patterns of expression of ERalpha and PR with each other, but a subset of cases in each tumor category exhibits unique ERalpha/PR immunoprofiles depletion of HDAC2 results in simultaneous depletion of ER and PR, and potentiates the effects of antihormonal therapy in ER-positive cells The association between Akt activation and PR negative expression was observed even in the ER-positive cases luminal ER(+)PR(+) breast tumors contain a minor ER(-)PR(-)CK5(+) population that has the capacity to generate the majority of ER(+)PR(+)CK18(+)CK5(-) cells |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Findings suggest a strong age-related selective growth advantage for breast tumour cells belonging to the ER+PR+HER-2+ subgroup |
Human | AKR1C2 | 1646 | aldo-keto reductase family 1, member C2 | Loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors |
Human | CSN2 | 1447 | casein beta | a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene |
Human | PRDM1 | 639 | PR domain containing 1, with ZNF domain | PRDI-BF1 beta is abundantly expressed in myeloma cell lines through alternative transcription initiation, has a disrupted PR domain and a significantly impaired transcription repressor function on multiple target genes |