Human | EBF3 | 253738 | early B-cell factor 3 | Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Mir-21 is a putative oncogenic microRNA in Head and Neck Squamous Cell Carcinoma (HNSCC) |
Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | Frequent methylation of SLC5A8 gene is associated with head and neck squamous cell carcinoma |
Human | GPBAR1 | 151306 | G protein-coupled bile acid receptor 1 | Combined blockade of both epidermal growth factor receptors and GPCRs may be a rational strategy to treat cancers, including head and neck squamous cell carcinoma that shows cross-talk between GPCR and EGFR signaling pathways |
Human | CD109 | 135228 | CD109 molecule | CD109 expression in squamous cell carcinoma of the uterine cervix. The result demonstrated that CD109 expression is significantly higher in cervical squamous cell carcinomas than in endometrial adenocarcinomas and normal cervix and endometrium. In the present study CD109 expression in cervical squamous cell carcinoma was compared with that in endometrial adenocarcinoma by reverse transcription polymerase chain reaction (RT-PCR). |
Human | IRX1 | 79192 | iroquois homeobox 1 | Frequent methylation of IRX1 gene is associated with head and neck squamous cell carcinoma |
Human | HPSE2 | 60495 | heparanase 2 | Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas |
Human | CCNL1 | 57018 | cyclin L1 | study suggests that cyclin l1 may have a role in RNA processing complex anc ould participate in tumor progression of head and neck squamous cell carcinoma |
Human | EGLN1 | 54583 | egl-9 family hypoxia-inducible factor 1 | PHD2 shows strongly elevated expression both at the mRNA and protein level in head and neck squamous cell carcinoma |
Human | DDIT4 | 54541 | DNA-damage-inducible transcript 4 | results suggest a novel mechanism by which AMPK activation after hypoxia-induced energy stress may be crucial in regulating REDD1 expression to control the mTOR pathway in head and neck squamous cell carcinoma |
Human | FXYD5 | 53827 | FXYD domain containing ion transport regulator 5 | Click here to display 5 evidence detail records. |
Human | PLCE1 | 51196 | phospholipase C, epsilon 1 | CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression |
Human | CADM1 | 23705 | cell adhesion molecule 1 | We detected TSLC1 promoter hypermethylation in seven (35%, 95% CI = 15% to 59%) of 20 high-grade CIN lesions (i.e., CIN II and III) and in 30 (58%, 95% CI = 43% to 71%) of 52 cervical squamous cell carcinomas compared with none (0%, 95% CI = 0% to 34%) of nine normal cervical epithelial biopsy samples and none (0%, 95% CI = 0% to 22%) of 12 CIN I lesions (P<.001 for cervical squamous cell cancer versus normal epithelial biopsy samples plus CIN I lesions). |
Human | ARHGEF12 | 23365 | Rho guanine nucleotide exchange factor (GEF) 12 | CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | promoter methylation studied in 80 patients with head and neck squamous cell carcinoma (HNSCC) |
Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | We showed that LEKTI is a potent inhibitor of a family of serine proteinases involved in extracellular matrix remodeling and its expression is downregulated in head and neck squamous cell carcinomas |
Human | SEMA4D | 10507 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | Data show that semaphorin 4D (Sema4D), a protein originally shown to regulate axonal growth cone guidance in the developing central nervous system, is highly expressed in cell lines derived from head and neck squamous cell carcinomas |
Human | AKT3 | 10000 | v-akt murine thymoma viral oncogene homolog 3 | Dysregulation of the PI 3-K/AKT/PTEN pathway may contribute to early head neck squamous cell carcinoma tumorigenesis |
Human | MRC2 | 9902 | mannose receptor, C type 2 | Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen |
Human | RHOBTB1 | 9886 | Rho-related BTB domain containing 1 | Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma) |
Human | CXCL14 | 9547 | chemokine (C-X-C motif) ligand 14 | Expression in tumors was heterogeneous, with the majority of HNSCCs and some cervical squamous cell carcinomas (SCCs) showing loss of BRAK mRNA. The majority of head and neck squamous cell carcinoma (HNSCC) and some cervical squamous cell carcinoma do not express CXCL14 mRNA, as opposed to constitutive expression by normal oral squamous epithelium. |
Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | promoter methylation and subsequent transcript downregulation of SOCS-3 transcripts and, to a much lesser extent, SOCS-1 are involved in the multistep carcinogenesis of head and neck squamous cell carcinoma |
Human | CFLAR | 8837 | CASP8 and FADD-like apoptosis regulator | Overexpression of cFLIP(L) is a frequent event in head and neck squamous cell carcinoma |
Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | TNFRSF10A is more frequent in CLL, mantle cell lymphoma, prostate cancer, bladder cancer and head and neck squamous cell carcinoma |
Human | SOCS1 | 8651 | suppressor of cytokine signaling 1 | Hypermethylation of SOCS-1 was found in about one-third of human head and neck squamous cell carcinomas tissues,SOCS-1 methylation status can differentially affect STAT3 activation |