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Details
Link-It Detail - Disease - Malignant Bone Neoplasm
Debug Stats
  • ### Total Build Time: 63 ms 38.686 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 344 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=1 ms Completed: 1 ms rowSize= 971 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=39 ms Completed: 39 ms rowSize= 13.250 KB
  • CONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 22.924 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.157 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Malignant Bone Neoplasm C0279530
Definition (1)

Cancer that starts in a bone is rare. Cancer that has spread to the bone from another part of the body is more common.

There are three types of bone cancer:

  • Osteosarcoma - develops in growing bones, usually between ages 10 and 25
  • Chondrosarcoma - starts in cartilage, usually after age 50
  • Ewing's sarcoma - begins in nerve tissue in bone marrow of young people, often after treatment of another condition with radiation or chemotherapy

The most common symptom of bone cancer is pain. Other symptoms may vary depending on the location and size of the cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy and radiation.

NIH: National Cancer Institute

Relationships (33)

Relation Types:
diso_​to_​anat : 4
diso_​to_​diso : 29


Relationships:
associated_​with : 1
is_​abnormal_​cell_​of_​disease : 2
is_​associated_​anatomic_​site_​of : 2
is_​not_​finding_​of_​disease : 1
isa : 25
related_​to : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_associated_anatomic_site_ofimg Connective and Soft Tissue C1516798
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_associated_anatomic_site_ofimg Skeletal bone C0262950
DISO_to_DISOisaimg Adamantinoma C1367554
DISO_to_DISOisaimg BONE NEOPLASM SECONDARY C0153690
DISO_to_DISOrelated_toimg Bone Diseases C0005940
DISO_to_DISOisaimg Bone Lymphoma C1332582
DISO_to_DISOused_forimg Bone Neoplasms C0005967
DISO_to_DISOisaimg Bone Sarcoma C1704327
DISO_to_DISOisaimg Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor of Bone C1333481
DISO_to_DISOis_not_finding_of_diseaseimg Indolent Clinical Course C1334168
DISO_to_DISOisaimg Local recurrence of malignant tumor of bone C1282484
DISO_to_DISOisaimg Malignant Bone Neoplasm of Chest Wall C1334572
DISO_to_DISOassociated_withimg Malignant Neoplasms C0006826
DISO_to_DISOisaimg Malignant neoplasm of Xiphoid process C0346676
DISO_to_DISOisaimg Malignant neoplasm of bone of lower limb C0559061
DISO_to_DISOisaimg Malignant neoplasm of bones of skull and face C0346653
DISO_to_DISOisaimg Malignant neoplasm of carpal C0346684
DISO_to_DISOisaimg Malignant neoplasm of hand bones C0346683
DISO_to_DISOisaimg Malignant neoplasm of laryngeal cartilage C0153486
DISO_to_DISOisaimg Malignant neoplasm of mandible C0153511
DISO_to_DISOisaimg Malignant neoplasm of pelvic bones, sacrum and coccyx C0153516
DISO_to_DISOisaimg Malignant neoplasm of ribs, sternum and clavicle C0153513
DISO_to_DISOisaimg Malignant neoplasm of scapula and long bones of upper arm C0346677
Genes (12)

Species:
human : 11
mouse : 1
SpeciesGeneGeneIdGene NameEvidence
MouseTNFRSF11B4982tumor necrosis factor receptor superfamily, member 11b
img NCI, Score=801, Pubmed Id: 10802707, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 11358823, UMLKSK CUI: C0279530
HumanTNFRSF11A8792tumor necrosis factor receptor superfamily, member 11a, NFKB activator
img NCI, Score=801, Pubmed Id: 15615497, UMLKSK CUI: C0279530
img GENERIF, Score=694, Pubmed Id: 15615497, UMLKSK CUI: C0279530
HumanTNFSF118600tumor necrosis factor (ligand) superfamily, member 11
img NCI, Score=801, Pubmed Id: 11485016, UMLKSK CUI: C0279530
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
img GAD, Score=1000, Pubmed Id: 14528100, UMLKSK CUI: C0279530
img GENERIF, Score=1000, Pubmed Id: 14528100, UMLKSK CUI: C0279530
HumanTNFRSF11B4982tumor necrosis factor receptor superfamily, member 11b
img NCI, Score=801, Pubmed Id: 15101876, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 11485016, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 12564836, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 10802707, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 15615497, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 15615497, UMLKSK CUI: C0279530
HumanNME14830NME/NM23 nucleoside diphosphate kinase 1
img NCI, Score=801, Pubmed Id: 7593131, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 7593131, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 7593131, UMLKSK CUI: C0279530
img NCI, Score=801, Pubmed Id: 11825445, UMLKSK CUI: C0279530
HumanGHRHR2692growth hormone releasing hormone receptor
img GENERIF, Score=912, Pubmed Id: 12220726, UMLKSK CUI: C0279530
HumanGHRH2691growth hormone releasing hormone
img NCI, Score=801, Pubmed Id: 12220726, UMLKSK CUI: C0279530
HumanESR12099estrogen receptor 1
img GAD, Score=1000, Pubmed Id: 14528100, UMLKSK CUI: C0279530
HumanCOL1A11277collagen, type I, alpha 1
img GAD, Score=1000, Pubmed Id: 14528100, UMLKSK CUI: C0279530
HumanCDH171015cadherin 17, LI cadherin (liver-intestine)
img NCI, Score=801, Pubmed Id: 11903580, UMLKSK CUI: C0279530
HumanCALCB797calcitonin-related polypeptide beta
img NCI, Score=801, Pubmed Id: 3493259, UMLKSK CUI: C0279530
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0279530Malignant Bone Neoplasm0self