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Genes (12)
Species: human : 11 mouse : 1 | |
| Mouse | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Here we show that osteoprotegerin, a secreted ;decoy; receptor that inhibits osteoclast activity, also blocks behaviors indicative of pain in mice with bone cancer. Osteoprotegerin diminishes advanced bone cancer pain. | | Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | disruption of the RANKL-RANK axis with OPG inhibited tumor-induced osteoclastogenesis and decreased bone cancer pain Having established that RANK ligand contributed to cancer-induced osteoclastogenesis, it was determined that disruption of the RANKL-RANK axis with OPG inhibited tumor-induced osteoclastogenesis and decreased bone cancer pain. | | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | Abnormalities of the RANKL/OPG system have been implicated in the pathogenesis of postmenopausal osteoporosis, rheumatoid arthritis, Pagets disease, periodontal disease, benign and malignant bone tumors, bone metastases, and hypercalcemia of malignancy, while administration of OPG has been demonstrated to prevent or mitigate these disorders in animal models. | | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Title:Analysis of Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Collagen Ialpha1 Genes and Their Relationship With Height in Children With Bone Cancer|Association:Not Found|Conclusion:Children with bone cancer are significantly taller than the reference population, which may be influenced by the genotype for the Fok I polymorphism of the VDR gene. Children with bone cancer are significantly taller than the reference population, which may be influenced by the genotype for the Fok I polymorphism of the VDR gene | | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Having established that RANK ligand contributed to cancer-induced osteoclastogenesis, it was determined that disruption of the RANKL-RANK axis with OPG inhibited tumor-induced osteoclastogenesis and decreased bone cancer pain. These results demonstrate that excessive tumor-induced bone destruction is involved in the generation of bone cancer pain and that osteoprotegerin may provide an effective treatment for this common human condition. This review examines the current evidence indicating that OPG increases bone mass, and discusses other possible beneficial effects of OPG, such as inhibition of tumour growth and relief from bone cancer pain. Abnormalities of the RANKL/OPG system have been implicated in the pathogenesis of postmenopausal osteoporosis, rheumatoid arthritis, Paget;s disease, periodontal disease, benign and malignant bone tumors, bone metastases, and hypercalcemia of malignancy, while administration of OPG has been demonstrated to prevent or mitigate these disorders in animal models. Bone cancer pain and the role of RANKL/OPG. To determine whether this mouse model of bone cancer could be used to define the basic mechanisms giving rise to bone cancer pain, we targeted excessive osteoclast activity using osteoprotegerin, a secreted decoy receptor that inhibits osteoclast activity. | | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Expression levels of nm23 protein in 72 malignant bone tumors comprising 41 osteosarcomas, 22 chondrosarcomas, 6 Ewings sarcomas, and 2 malignant fibrous histiocytomas were examined immunohistochemically, using anti-nm23 protein polyclonal antibody, and compared with 51 cases of benign bone tumors or tumor-like lesions. [Association of nm23-H1 with orthopedic oncological conditions] OBJECTIVE: To explore the correlation between nm23-H1 gene and malignant and semi-malignant bone tumors. Immunohistochemical analysis of nm23 protein expression in malignant bone tumors. Malignant bone tumors showed significantly higher nm23 protein expression than benign bone tumors or tumor-like lesions (P < 0.0001). | | Human | GHRHR | 2692 | growth hormone releasing hormone receptor | expression of mRNA and splice variants of this receptor in human malignant bone tumors | | Human | GHRH | 2691 | growth hormone releasing hormone | The direct antiproliferative effects of GHRH antagonists on malignant bone tumors appear to be exerted through the SV(1) of GHRH receptors on tumoral cells. | | Human | ESR1 | 2099 | estrogen receptor 1 | Title:Analysis of Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Collagen Ialpha1 Genes and Their Relationship With Height in Children With Bone Cancer|Association:Not Found|Conclusion:Children with bone cancer are significantly taller than the reference population, which may be influenced by the genotype for the Fok I polymorphism of the VDR gene. | | Human | COL1A1 | 1277 | collagen, type I, alpha 1 | Title:Analysis of Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Collagen Ialpha1 Genes and Their Relationship With Height in Children With Bone Cancer|Association:Not Found|Conclusion:Children with bone cancer are significantly taller than the reference population, which may be influenced by the genotype for the Fok I polymorphism of the VDR gene. | | Human | CDH17 | 1015 | cadherin 17, LI cadherin (liver-intestine) | AIMS: Members of the cadherin and catenin families are involved in chondrogenesis and catenin gene mutations have been detected in malignant tumours of bone. | | Human | CALCB | 797 | calcitonin-related polypeptide beta | In this study, expression of the CALC-II gene was demonstrated by Northern blot hybridization analysis in four of six cell lines established from different Ewing sarcomas, a malignant neoplasm of bone. |
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