Genes (162)
Species:
human : 160 mouse : 2 | |
| Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | The nm23 gene, a putative metastasis suppressor gene, was originally identified by its reduced expression in highly metastatic K-1735 murine melanoma cell lines, as compared to related, low metastatic melanoma cell lines. | | Mouse | NMB | 4828 | neuromedin B | Transfection of a partial nmb cDNA into a highly metastatic melanoma cell line (BLM) resulted, in 2 of 3 transfectants, in slower subcutaneous tumor growth and, in 1 of 3 transfectants, in reduction of the potential for spontaneous metastasis in nude mice. | | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | METHODS: In the present study we utilized the 2/60 clone of Me665/2 human metastatic melanoma, which displays high levels of GGT activity, in order to verify if the presence of this enzyme--through the promotion of redox processes--may influence the activation status of NF-kappaB. | | Human | CTHRC1 | 115908 | collagen triple helix repeat containing 1 | There was a further increase of CTHRC1 protein in metastatic melanoma specimens compared with nonmetastatic lesions (P _lt_ 0.01, chi(2) test). | | Human | TUBA1C | 84790 | tubulin, alpha 1c | The main difference between benign and malignant melanocytic tumors was found in the stromal cells: In melanocytic nevi, the stromal fibroblasts were entirely tubulin negative; whereas, adjacent to the invasive edge in primary and metastatic malignant melanoma, the stroma fibroblasts were strongly positive. | | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | Is MAGE-1 expression in metastatic malignant melanomas really helpful? We have analyzed the T cell responses of HLA-A1 metastatic melanoma patients with detectable disease, following vaccination with a recombinant ALVAC virus, which bears short MAGE-1 and MAGE-3 sequences coding for antigenic peptides presented by HLA-A1. | | Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | By analyzing the immune response of a metastatic melanoma patient who achieved a long-term response to vaccination, we identified melanoma inhibitor of apoptosis protein (ML-IAP) as a target for immune-mediated tumor destruction. | | Human | TRPC7 | 57113 | transient receptor potential cation channel, subfamily C, member 7 | We recently described a novel putative Ca(2+) channel gene, MTR1, which shows a high level of homology to the human TRPC7 gene and the melastatin 1 (MLSN1) gene, another Trp (transient receptor potential protein)-related gene whose transcript was found to be downregulated in metastatic melanomas. The highest homologies are observed with the human TRPC7 and with melastatin 1 ( MLSN1 ), whose transcript is downregulated in metastatic melanomas. | | Human | GSDMC | 56169 | gasdermin C | Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. | | Human | LEF1 | 51176 | lymphoid enhancer-binding factor 1 | We show that LEF-1 mRNA expression is predominant in highly migrating cells from metastatic melanomas. | | Human | FOXP3 | 50943 | forkhead box P3 | Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. | | Human | SPANXA1 | 30014 | sperm protein associated with the nucleus, X-linked, family member A1 | Over expression of SPAN-x protein is associated with nonlymphatic metastatic melanomas | | Human | TRPM5 | 29850 | transient receptor potential cation channel, subfamily M, member 5 | We recently described a novel putative Ca(2+) channel gene, MTR1, which shows a high level of homology to the human TRPC7 gene and the melastatin 1 (MLSN1) gene, another Trp (transient receptor potential protein)-related gene whose transcript was found to be downregulated in metastatic melanomas. | | Human | BBC3 | 27113 | BCL2 binding component 3 | Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P_lt_0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). We used tissue microarray and immunohistochemistry to examine PUMA expression in 107 primary melanomas, 51 metastatic melanomas, and 64 dysplastic nevi. | | Human | PHLDA1 | 22822 | pleckstrin homology-like domain, family A, member 1 | Monoclonal antibodies produced against the PHLDA1 protein revealed homogeneous strong expression by benign melanocytic nevi, and progressively reduced expression in primary and metastatic melanomas in vivo. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. | | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | Demonstration of activation in cells derived from two human metastatic melanomas and also in three of seven cutaneous metastatic melanoma tissues | | Human | PTP4A3 | 11156 | protein tyrosine phosphatase type IVA, member 3 | PRL-3 was also highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells. | | Human | OGFR | 11054 | opioid growth factor receptor | Using sera from a long-term surviving metastatic melanoma patient vaccinated with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), we identified an antigen reported to be a putative opioid growth factor receptor (OGFr). | | Human | IL24 | 11009 | interleukin 24 | Title:|Association:Y|Conclusion:Not Found | | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | Also, the relative high expression of Jab1 in metastatic melanoma, associated with low levels of p27, suggests that Jab1 may be involved in survival and proliferation of metastatic melanoma cells. High expression of Jab1 in metastatic melanoma suggests that Jab1 may be involved in survival and proliferation of metastatic melanoma cells In metastatic melanomas, there was a negative correlation between p27 and Jab1 expression (r=-0.166). Jab1 was expressed in 14 (82%) standard nevi, 18 (95%) dysplastic nevi, 17 (77%) melanomas, and 16 (53%) of the metastatic melanomas (P<0.01). | | Human | RAB32 | 10981 | RAB32, member RAS oncogene family | We show that in murine amelanotic in vitro transformed melanocytes as well as in human amelanotic metastatic melanoma cell lines, the expression of Rab32 is markedly reduced or absent, in parallel with the loss of expression of two key enzymes for the production of melanin, tyrosinase and Tyrp1. | | Human | HPSE | 10855 | heparanase | one of the roles CREB plays in the acquisition of melanoma cells metastatic phenotype is affecting HPSE-1 activity heparanase modifies FGF2 binding, signaling, and angiogenesis in metastatic melanoma cells | | Human | NES | 10763 | nestin | Nestin mRNA was detected in 24 of 34 metastatic melanomas and in 1 of 4 benign nevi, whereas the protein was expressed in 10 of 15 primary melanomas, in 29 of 34 metastatic tumors, and in 3 of 4 nevi. The high fraction of melanocytic tumors which express nestin, particularly the metastatic melanomas, suggests that nestin may be a useful marker for such malignancies. | | Human | GNA13 | 10672 | guanine nucleotide binding protein (G protein), alpha 13 | G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis | | Human | GNB2L1 | 10399 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | RACK1 overexpression detected in situ in human melanoma specimens characterized cutaneous and metastatic melanoma raising the possibility that RACK1 can be a potential marker of malignancy in human melanoma |
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