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Genes (20)
Species:
human : 19 mouse : 1 | |
| Mouse | EZR | 7430 | ezrin | In a mouse model of osteosarcoma, a highly metastatic pediatric cancer, we found ezrin to be necessary for metastasis. | | Human | PALB2 | 79728 | partner and localizer of BRCA2 | We identified pathogenic mutations in PALB2 (also known as FANCN) in seven families affected with Fanconi anemia and cancer in early childhood, demonstrating that biallelic PALB2 mutations cause a new subtype of Fanconi anemia, FA-N, and, similar to biallelic BRCA2 mutations, confer a high risk of childhood cancer. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. | | Human | AXIN1 | 8312 | axin 1 | a tumor-associated mutation of the Axin gene is generally a rare event in pediatric neoplasms | | Human | EZR | 7430 | ezrin | Moreover, Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers. The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer. | | Human | SIX1 | 6495 | SIX homeobox 1 | The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer. | | Human | SHH | 6469 | sonic hedgehog | The Sonic hedgehog (Shh) signaling pathway plays a critical role in normal cerebellar development and has been implicated in medulloblastomas, common malignant childhood tumors of the cerebellum. | | Human | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | information on the phenotype associated with PMS2 mutations in childhood cancer in 13 patients from six families of Pakistani origin living in the United Kingdom PMS2 mutations in childhood cancer. Apparently, not only MLH1, MSH2 and PMS2, but also MSH6 is involved in the syndrome of childhood cancer and signs of neurofibromatosis type 1. PMS2 mutations in childhood cancer. PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome provide further evidence for childhood cancer syndrome in six children from two consanguineous families carrying homozygous PMS2 germline mutations | | Human | PAX7 | 5081 | paired box 7 | In the pediatric cancer alveolar rhabdomyosarcoma, the common 2;13 and less frequent 1;13 translocations fuse PAX3 and PAX7, respectively, with FKHR to produce chimeric genes. | | Human | PAX3 | 5077 | paired box 3 | In the pediatric cancer alveolar rhabdomyosarcoma, the (2;13)(q35;q14) translocation juxtaposes PAX3 and FKHR to produce a chimeric PAX3-FKHR gene. In the pediatric cancer alveolar rhabdomyosarcoma (ARMS), the 2;13 chromosomal translocation juxtaposes the PAX3 and FKHR genes to generate a chimeric transcription factor. In the pediatric cancer alveolar rhabdomyosarcoma, characteristic t(2;13)(q35;q14) or variant t(1;13)(p36;q14) chromosomal translocations generate PAX3-FKHR or PAX7-FKHR fusion genes. In the pediatric cancer alveolar rhabdomyosarcoma, the common 2;13 and less frequent 1;13 translocations fuse PAX3 and PAX7, respectively, with FKHR to produce chimeric genes. | | Human | MYCN | 4613 | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | We have recently shown that although a majority of human neuroblastomas (NBs), a childhood cancer, express high levels of CD44H, high stages and tumors with amplification of the NMYC proto-oncogene fail to express CD44. In the childhood cancer neuroblastoma (NB), the level of expression of the multidrug resistance-associated protein (MRP1) gene is strongly correlated with expression of the MYCN oncogene in primary NB tumors, suggesting that MRP1 may be a target for MYCN-mediated gene regulation. | | Human | LEPR | 3953 | leptin receptor | Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. | | Human | JAK3 | 3718 | Janus kinase 3 | The high potency and selectivity of WHI-P131 for JAK3 makes it a promising candidate for new treatment strategies against ALL, the most common form of childhood cancer. Potent and specific inhibitors of JAK3 such as WHI-P131 may provide the basis for the design of new treatment strategies against acute lymphoblastic leukemia, the most common form of childhood cancer. | | Human | IGFBP5 | 3488 | insulin-like growth factor binding protein 5 | In neuroblastoma (NB), a malignant childhood tumor, we found that IGFBP-5 is frequently expressed. | | Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Several lines of evidence now indicate that type 1 insulin-like growth factor receptor (IGF1R) function may be particularly important in the pathogenesis of the pediatric cancer neuroblastoma. | | Human | FOXO1 | 2308 | forkhead box O1 | In the pediatric cancer alveolar rhabdomyosarcoma (ARMS), the 2;13 chromosomal translocation juxtaposes the PAX3 and FKHR genes to generate a chimeric transcription factor. In the pediatric cancer alveolar rhabdomyosarcoma, the (2;13)(q35;q14) translocation juxtaposes PAX3 and FKHR to produce a chimeric PAX3-FKHR gene. In the pediatric cancer alveolar rhabdomyosarcoma, the common 2;13 and less frequent 1;13 translocations fuse PAX3 and PAX7, respectively, with FKHR to produce chimeric genes. | | Human | COL1A1 | 1277 | collagen, type I, alpha 1 | COLIA1 genotype may affect bone accrual in a population treated for childhood cancer Association of collagen type I alpha1 gene polymorphism with bone density in survivors of childhood cancer--preliminary report. | | Human | CD80 | 941 | CD80 molecule | Lower percentages of monocytes with CD80, CD86 and HLA-DR molecule expression in pediatric cancer. | | Human | CAT | 847 | catalase | The catalase gene is the closest genetic marker mapped to Wilms tumor, one of the most prevalent of childhood cancers. | | Human | BUB1B | 701 | BUB1 mitotic checkpoint serine/threonine kinase B | However, recently we identified mutations in the mitotic checkpoint gene BUB1B in an autosomal recessive condition characterized by mosaic aneuploidies and childhood cancers. | | Human | ALPP | 250 | alkaline phosphatase, placental | Elevations of alkaline phosphatase is associated with therapy related pediatric cancer |
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