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Genes (143)
Species: human : 143 | |
Human | MIR27A | 407018 | microRNA 27a | MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin | Human | AMIGO2 | 347902 | adhesion molecule with Ig-like domain 2 | We have discovered DEGA, a novel cDNA differentially expressed in human gastric adenocarcinomas. | Human | GKN2 | 200504 | gastrokine 2 | GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype | Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | RESULTS: The expression rate of DARPP-32 protein in gastric adenocarcinoma tissue (92.7%) was significantly higher than that in normal gastric mucosa (52.6%, P < 0.05). As compared with adjacent non-carcinomatous gastric mucosa, both DARPP-32 and its truncated isoform t-DARPP were overexpressed in gastric adenocarcinoma tissue (t = 2.45, P = 0.015); and t-DARPP overexpression was more frequently seen. RESULTS: The expression rate of DARPP-32 protein in gastric adenocarcinoma tissue (92.7%) was significantly higher than that in normal gastric mucosa (52.6%, P _lt_ 0.05). As compared with adjacent non-carcinomatous gastric mucosa, both DARPP-32 and its truncated isoform t-DARPP were overexpressed in gastric adenocarcinoma tissue (t = 2.45, P = 0.015); and t-DARPP overexpression was more frequently seen. | Human | REG4 | 83998 | regenerating islet-derived family, member 4 | Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. Among 143 gastric adenocarcinomas, Reg IV expression was detected in 42 (29.4%) and was associated with both the intestinal mucin phenotype and neuroendocrine differentiation. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. Among 143 gastric adenocarcinomas, Reg IV expression was detected in 42 (29.4%) and was associated with both the intestinal mucin phenotype and neuroendocrine differentiation. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | Compared with corresponding normal tissue, MUC1 mRNA levels were increased in breast cancer and well-differentiated lung cancers, and MUC3 mRNA was increased in gastric adenocarcinomas. | Human | GKN1 | 56287 | gastrokine 1 | GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype | Human | XAF1 | 54739 | XIAP associated factor 1 | An increased expression ratio of XIAP to XAF1 in combination with a disturbed expression of the XAF1 splice variants could be shown in gastric adenocarcinomas | Human | PLUNC | 51297 | | PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma | Human | A4GNT | 51146 | alpha-1,4-N-acetylglucosaminyltransferase | Transfection of alpha4GnT cDNA into gastric adenocarcinoma AGS cells produced class III mucin, indicating that alpha4GnT is responsible for the formation of class III Con A reactivity. The specificity of the antibody was confirmed by analyses of human gastric adenocarcinoma AGS cells transfected by alpha4GnT cDNA. | Human | SH3GLB1 | 51100 | SH3-domain GRB2-like endophilin B1 | The aim of this study was to explore whether alteration of Bif-1 expression might be a characteristic of gastric cancer.Methods: We analysed the expression of Bif-1 protein in 60 gastric adenocarcinomas by immunohistochemistry using a tissue microarray approach.Results: In normal gastric mucosal cells, surface and glandular epithelial cells strongly expressed Bif-1. METHODS: We analysed the expression of Bif-1 protein in 60 gastric adenocarcinomas by immunohistochemistry using a tissue microarray approach. | Human | HTRA2 | 27429 | HtrA serine peptidase 2 | In the current study, we analyzed the expression of Omi/HtrA2 in 60 advanced gastric adenocarcinomas by immunohistochemistry using a tissue microarray approach. | Human | BBC3 | 27113 | BCL2 binding component 3 | Differential expression of PUMA between normal and neoplastic gastric cells suggests that regulation of PUMA expression might play a possible role in the development of gastric adenocarcinoma | Human | CKAP2 | 26586 | cytoskeleton associated protein 2 | CONCLUSION: When these points were taken together, we concluded that CKAP2 is up-regulated in primary human gastric adenocarcinomas at high frequency and might be useful for diagnosing and discriminating adenocarcinomas from tubular adenomas of the stomach. | Human | MYEOV | 26579 | myeloma overexpressed | The putative role for MYEOV genes may provide important targets for intervention in Gastric adenocarcinoma, evidenced by their role in promoting invasion and proliferation, key phenotypic hallmarks of cancer cells | Human | GNL3 | 26354 | guanine nucleotide binding protein-like 3 (nucleolar) | Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization. | Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. In gastric adenocarcinoma, hypermethylation frequently targets HPP1. We sought then to determine the prevalence of HPP1 silencing by DNA methylation in gastric adenocarcinomas and to define any association of this event with microsatellite instability (MSI) or hMLH1 hypermethylation. | Human | PRND | 23627 | prion protein 2 (dublet) | High levels of PRND were also found in non-glial malignant tumor samples, such as gastric adenocarcinoma and anaplastic meningioma. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | In addition, carcinomas arising from tissues normally not expressing AMACR were also positive for the antigen, including 17 of 18 (94%) prostate carcinomas, 9 of 29 (31%) of urothelial carcinomas, and 4 of 15 (27%) of gastric adenocarcinomas. | Human | IGAD1 | 10986 | immunoglobulin A (IgA) deficiency susceptibility 1 | associated with autoimmunity and cancer in humans(stomach adenocarcinoma)by interacting with immunoreceptors that bear ITAM motif | Human | NES | 10763 | nestin | Comparative evaluation of angiogenesis in gastric adenocarcinoma by nestin and CD34. | Human | UBE2E3 | 10477 | ubiquitin-conjugating enzyme E2E 3 | A cDNA encoding a third member of human class III ubiquitin-conjugating enzymes (E2s), UBE2E3, was cloned from a human gastric adenocarcinoma cDNA library. | Human | NET1 | 10276 | neuroepithelial cell transforming 1 | The putative role for NET1 genes may provide important targets for intervention in Gastric adenocarcinoma, evidenced by their role in promoting invasion and proliferation, key phenotypic hallmarks of cancer cells | Human | MVP | 9961 | major vault protein | In 20 gastric adenocarcinomas, 11 (55%), 2 (10%), and 0 (0%) were positive for MRP, LRP, and P-Gp. | Human | PTGES | 9536 | prostaglandin E synthase | Furthermore, mPGES-1 mRNA, protein and microsomal PGES activity were detected in gastric adenocarcinoma cell lines that originated from intestinal type tumors (MKN-7 and MKN-28). |
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