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Details
Link-It Detail - Disease - MPTP Poisoning
Debug Stats
  • ### Total Build Time: 25 ms 20.821 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 326 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 564 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 1,005 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 5.387 KB
  • CONCEPT_RELATIONSHIPS gt=8 ms Completed: 8 ms rowSize= 12.173 KB
  • CONCEPT_GENES gt=1 ms Completed: 1 ms rowSize= 45 bytes
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.148 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
MPTP Poisoning C0270730
Definition (1)
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Semantic Types (1)
Injury or Poisoning (T037)
Parents (2)
img Parkinson Disease, Secondary C0030569
img Neurotoxicity Syndromes C0235032
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076827img Parkinson Disease, Secondary C0030569
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Parkinson Disease, Secondary C0030569
img Mental Disorders C0004936img Substance-Related Disorders C02369695img Neurotoxicity Syndromes C0235032
img Nervous System Diseases C0027765img Neurotoxicity Syndromes C02350323img Neurotoxicity Syndromes C0235032
Relationships (38)

Relation Types:
diso_​to_​anat : 12
diso_​to_​chem : 14
diso_​to_​diso : 10
diso_​to_​phen : 2


Relationships:
none : 37
entry_​version_​of : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM50img Dopamine C0013030
DISO_to_CHEM47img Agents, Neuroprotective C0242912
DISO_to_ANAT44img Corpus Striatum C0010097
DISO_to_ANAT44img Neurons C0027882
DISO_to_ANAT33img Substantia Nigra C0038590
DISO_to_DISO32img chemically induced C0007994
DISO_to_ANAT29img Neurons C0027882
DISO_to_DISO27img Parkinson Disease C0030567
DISO_to_ANAT26img Corpus Striatum C0010097
DISO_to_CHEM26img Agents, Neuroprotective C0242912
DISO_to_CHEM24img 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) C0000097
DISO_to_CHEM23img 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) C0000097
DISO_to_CHEM23img Dopamine C0013030
DISO_to_DISO23img Parkinson Disease, Secondary C0030569
DISO_to_DISO22img Complication Aspects C1171258
DISO_to_ANAT21img Brain C0006104
DISO_to_PHEN21img genetic aspects C0017399
DISO_to_ANAT18img Substantia Nigra C0038590
DISO_to_DISO17img Degeneration, Nerve C0027746
DISO_to_ANAT16img Dopaminergic Cell C1512035
DISO_to_DISO15img Animal Disease Models C0012644
DISO_to_DISO15img chemically induced C0007994
DISO_to_CHEM14img (-)-3-(3,4-Dihydroxyphenyl)-L-alanine C0023570
DISO_to_CHEM14img Antiparkinson Agents C0003405
DISO_to_DISO13img Parkinsonian Disorders C0242422
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0270730MPTP Poisoning0self