Human | TLR4 | 7099 | toll-like receptor 4 | TLR4 may participate in cerebral ischemic injury through an MyD88-independent signal pathway |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | This study proposes a novel mechanism of TIMP-1 regulation, which ensures an increased supply of the inhibitor after brain injury, and limits extracellular matrix degradation |
Human | TGFBI | 7045 | transforming growth factor, beta-induced, 68kDa | Results suggest that alpha6beta4 integrin-mediated interactions of astrocytes with beta(ig)-h3 transduce intracellular signals through the focal adhesion proteins, which may regulate certain aspects of astrocyte response to brain injury |
Human | STC1 | 6781 | stanniocalcin 1 | Induced brain injury elicits a stronger STC-1 response in brains of transgenic mice, with targeted astroglial IL-6 expression, than in brains of wild-type mice |
Human | SLC8A1 | 6546 | solute carrier family 8 (sodium/calcium exchanger), member 1 | NKCC1 in conjunction with NCX1 plays a role in reperfusion-induced brain injury after ischemia |
Human | S100B | 6285 | S100 calcium binding protein B | This study provides evidence that circulating S100beta protein is increased in IUGR fetuses and correlates with cerebral hemodynamics, suggesting that it may represent an index of cerebral cell damage in the perinatal period Review summarizes current knowledge about S-100B serum measurements in severe head injury and concludes that S-100B belongs to a new generation of molecular serum markers of brain damage Serum S100beta levels may serve as a potentially useful early marker of postcraniotomy brain damage in patients undergoing elective meningioma resection S 100 B may be a reliable marker of brain damage in TBI without multiple trauma 24 h after trauma and thereafter preoperative S100B concentrations correlate inversely with the size of the ascending aorta in hypoplastic left heart syndrome and may serve as a marker for preexisting brain injury and mortality S100B has a role in exacerbating brain damage and periinfarct reactive gliosis (astrocytosis and microgliosis) during the subacute phase of middle cerebral artery occlusion Results in high-risk pregnancies demonstrated that S100B concentration increased in amniotic fluid and in cord blood of fetuses with brain damage [review] |
Human | PRNP | 5621 | prion protein | study suggests that PrPC has physiological relevance to cerebral ischemic injury and could be useful as a therapeutic target for the treatment of cerebral ischemia |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Astrocytes are a source of iNOS and may play a role in the evolution of pediatric brain injury days after the initial insult |
Human | NGF | 4803 | nerve growth factor (beta polypeptide) | NGF concentration in CSF is a useful marker of brain damage following severe TBI |
Human | MUT | 4594 | methylmalonyl CoA mutase | early hyperammonemia can lead to significant brain damage in methylmalonic acidemia |
Human | MPO | 4353 | myeloperoxidase | MPO polymorphism were associated with the extent of brain damage and the functional outcome rather than with the risk of developing brain infarction |
Human | MET | 4233 | met proto-oncogene | the HGF/c-MET axis has a role in guiding stem cells toward brain injury |
Human | MAPT | 4137 | microtubule-associated protein tau | INFERRED, Score=800, UMLKSK CUI: C0270611 |
Human | LEPR | 3953 | leptin receptor | study reports expression of the leptin receptor isoforms in osteocytes isolated from biopsies in brain injury-related heterotopic ossification |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices |
Human | HGF | 3082 | hepatocyte growth factor (hepapoietin A; scatter factor) | the HGF/c-MET axis has a role in guiding stem cells toward brain injury |
Human | GRN | 2896 | granulin | Increased PGRN expression by microglia may play a pivotal role in the response to brain injury, neuroinflammation and neurodegeneration |
Human | F13A1 | 2162 | coagulation factor XIII, A1 polypeptide | INFERRED, Score=800, UMLKSK CUI: C0270611 |
Human | EPO | 2056 | erythropoietin | Results show that recombinant human erythropoietin reduces brain injury, especially apoptotic cell death, after neonatal hypoxia-ischemia erythropoietin has a protective role against cancer and brain injury [review] |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | Data suggest that increased intrathecal release of Fas, but not FasL or caspase 3, in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation |
Human | CALM2 | 805 | calmodulin 2 (phosphorylase kinase, delta) | These results suggest that calmodulin plays a crucial role in the processes of Ca(2+)-induced neuronal cell death and the possibility that the blockage of calmodulin attenuates brain injury after cerebral ischemia |
Human | APOE | 348 | apolipoprotein E | Apoe4 affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 > apoE3 = apoE2) and is detected in neurons and astrocytes in the peri-infarct area of genetically engineered mice Evidence from these analyses supports current literature refuting the notion of relatively poorer neuropsychological functioning associated with the APOE-epsilon4 genotype among young adult participants shortly following mild or moderate brain injury |
Human | AGT | 183 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Title:|Association:Not Found|Conclusion:The B haplotype of the AGT promoter in the absence of the wild-type A haplotype might represent a genetic susceptibility factor for MARCD. |
Human | ADRB2 | 154 | adrenoceptor beta 2, surface | study demonstrated a significant decrease in beta2-adrenergic receptor mRNA level in brain injury-related heterotopic ossification samples and hypothesized a possible involvement of serum leptin variations in this decrease |
Human | ADM | 133 | adrenomedullin | ADM gene delivery protects against cerebral ischemic injury by promoting astrocyte migration and survival |