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Genes (36)
Species: human : 36 | |
| Human | IL24 | 11009 | interleukin 24 | polymorphisms investigated are not associated with chronic periodontitis | | Human | SMC3 | 9126 | structural maintenance of chromosomes 3 | There were greater levels of chondroitin sulphate WF6 epitope in gingival crevicular fluid from destructive sites of patients with chronic periodontitis compared with non-destructive sites of patients with gingivitis or chronic periodontitis | | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | RANKL levels appeared to be greater in the smokers with chronic periodontitis than in non-smokers with chronic periodontitis | | Human | IL1R2 | 7850 | interleukin 1 receptor, type II | was detected more often in chronic periodontitis gingival crevicular fluid than in aggressive periodontitis gingival crevicular fluid, and there was no correlation between gingival crevicular fluid concentration and clinical parameters | | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | The VDR haplotype constructed from the ApaI, BsmI, and FokI polymorphisms is related to the risk of severe chronic periodontitis in Japanese men | | Human | TNF | 7124 | tumor necrosis factor | This study failed to observe a significant difference in the -308TNF-alpha single-nucleotide polymorphism between chronic periodontitis patients and controls single nucleotide polymorphisms appear to be associated with severe adult periodontitis in Japanese populations | | Human | TLR4 | 7099 | toll-like receptor 4 | TLR4 gene polymoprhisms are not associated with susceptibility to chronic periodontitis in Turkish patients TLR4 gene polymorphisms are not significantly associated with the susceptibility to, or severity of, chronic periodontitis in a Czech population The Asp299Gly TLR4 gene polymorphism is associated with a decreased risk of aggressive periodontitis but not chronic periodontitis | | Human | TLR2 | 7097 | toll-like receptor 2 | TLR2 gene polymorphisms are not associated with susceptibility to chronic periodontitis in Turkish patients | | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied These findings suggest that the TGF-beta1 (+915C) polymorphic allele might be associated with chronic periodontitis in the Turkish population augmented in gingival crevicular fluid of smokers with chronic periodontitis | | Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | polymorphisms investigated are not associated with chronic periodontitis | | Human | PLAT | 5327 | plasminogen activator, tissue | Plasminogen activator inhibitor type 1 genotypes are not associated with susceptibility to chronic periodontitis in Turkish subjects | | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | relationships among adult periodontitis, smoking, and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene Tissue plasminogen activator genotypes are not associated with susceptibility to chronic periodontitis in Turkish subjects | | Human | OSM | 5008 | oncostatin M | OSM may play a role in modulating the inflammatory cascade of chronic periodontitis | | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | No association between the OPG polymorphisms and chronic periodontitis could be found Salivary osteoprotegerin (OPG) concentration was significantly lower and the sRANKL/OPG ratio was higher in smokers with chronic periodontitis than in non-smokers with chronic periodontitis | | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Non-surgical periodontal treatment was effective in reducing the levels of MMP9 in gingival crevicular fluid from diabetic patients with chronic periodontitis polymorphisms are not associated with the susceptibility to chronic periodontitis in the Czech population; however, the promoter variant may influence the severity of the disease in men | | Human | MMP8 | 4317 | matrix metallopeptidase 8 (neutrophil collagenase) | Non-surgical periodontal treatment was effective in reducing the levels of MMP8 in gingival crevicular fluid from diabetic patients with chronic periodontitis | | Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607bp may be associated with severe chronic periodontitis in a Chinese population Data suggest that the -1607 2G polymorphic allele of the MMP-1 gene could be associated with susceptibility to severe chronic periodontitis; the -519AG and GG genotypes may play a role in the outcome of periodontal therapy Title:MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population.|Association:Y|Conclusion:These results show that a polymorphism in the promoter region of MMP-1 gene is associated with the severe chronic periodontitis phenotype in non-smokers. a polymorphism in the promoter region is associated with the severe chronic periodontitis phenotype in non-smokers | | Human | LTA | 4049 | lymphotoxin alpha | Title:Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population.|Association:Not Found|Conclusion:Our data suggest that combined genotypes composed of the TNF-alpha and LT-alpha gene polymorphisms may influence the susceptibility to chronic periodontitis. We also showed that, comparing the two genes, the 1/1 genotype of the NcoI polymorphism in the first intron of the LT-alpha gene is a more informative marker and it may be one of the protective genetic factors against chronic periodontitis in our population. | | Human | INPP5D | 3635 | inositol polyphosphate-5-phosphatase, 145kDa | Upregulated in oral mucosa during chronic periodontitis compared to its level during gingival health | | Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Levels were higher in patients with chronic periodontitis compared with patients with gingivitis | | Human | IL12RB2 | 3595 | interleukin 12 receptor, beta 2 | frequencies of variant alleles were significantly higher in aggressive periodontitis patients as compared with healthy controls or chronic periodontitis patients | | Human | IL10 | 3586 | interleukin 10 | expression in chronic periodontitis lesions is associated with a distinct genotype This study failed to observe a significant difference in the -1082IL-10 single-nucleotide polymorphism between chronic periodontitis patients and controls | | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL-6 may play a role in modulating the inflammatory cascade of chronic periodontitis -572 G/C polymorphism may be one of the protective factors associated with lower susceptibility to chronic periodontitis The -174IL-6 single-nucleotide polymorphism are associated with susceptibility to chronic periodontitis in the population studied | | Human | IL4 | 3565 | interleukin 4 | The IL-4 gene locus (-590 C-->T polymorphism and 70 bp repeat polymorphism) contributes little to the interindividual susceptibility for adult periodontitis in a Korean population | | Human | IL2RA | 3559 | interleukin 2 receptor, alpha | Results showed that patients with chronic periodontitis presented increased frequency of T lymphocytes and CD4+CD25+ T cells in the inflammatory infiltrate of gingival tissues |
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