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Genes (36)
Species: human : 36 | |
Human | IL24 | 11009 | interleukin 24 | polymorphisms investigated are not associated with chronic periodontitis | Human | SMC3 | 9126 | structural maintenance of chromosomes 3 | There were greater levels of chondroitin sulphate WF6 epitope in gingival crevicular fluid from destructive sites of patients with chronic periodontitis compared with non-destructive sites of patients with gingivitis or chronic periodontitis | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | RANKL levels appeared to be greater in the smokers with chronic periodontitis than in non-smokers with chronic periodontitis | Human | IL1R2 | 7850 | interleukin 1 receptor, type II | was detected more often in chronic periodontitis gingival crevicular fluid than in aggressive periodontitis gingival crevicular fluid, and there was no correlation between gingival crevicular fluid concentration and clinical parameters | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | The VDR haplotype constructed from the ApaI, BsmI, and FokI polymorphisms is related to the risk of severe chronic periodontitis in Japanese men | Human | TNF | 7124 | tumor necrosis factor | This study failed to observe a significant difference in the -308TNF-alpha single-nucleotide polymorphism between chronic periodontitis patients and controls single nucleotide polymorphisms appear to be associated with severe adult periodontitis in Japanese populations | Human | TLR4 | 7099 | toll-like receptor 4 | TLR4 gene polymoprhisms are not associated with susceptibility to chronic periodontitis in Turkish patients The Asp299Gly TLR4 gene polymorphism is associated with a decreased risk of aggressive periodontitis but not chronic periodontitis TLR4 gene polymorphisms are not significantly associated with the susceptibility to, or severity of, chronic periodontitis in a Czech population | Human | TLR2 | 7097 | toll-like receptor 2 | TLR2 gene polymorphisms are not associated with susceptibility to chronic periodontitis in Turkish patients | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied augmented in gingival crevicular fluid of smokers with chronic periodontitis These findings suggest that the TGF-beta1 (+915C) polymorphic allele might be associated with chronic periodontitis in the Turkish population | Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | polymorphisms investigated are not associated with chronic periodontitis | Human | PLAT | 5327 | plasminogen activator, tissue | Plasminogen activator inhibitor type 1 genotypes are not associated with susceptibility to chronic periodontitis in Turkish subjects | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | relationships among adult periodontitis, smoking, and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene Tissue plasminogen activator genotypes are not associated with susceptibility to chronic periodontitis in Turkish subjects | Human | OSM | 5008 | oncostatin M | OSM may play a role in modulating the inflammatory cascade of chronic periodontitis | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Salivary osteoprotegerin (OPG) concentration was significantly lower and the sRANKL/OPG ratio was higher in smokers with chronic periodontitis than in non-smokers with chronic periodontitis No association between the OPG polymorphisms and chronic periodontitis could be found | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | polymorphisms are not associated with the susceptibility to chronic periodontitis in the Czech population; however, the promoter variant may influence the severity of the disease in men Non-surgical periodontal treatment was effective in reducing the levels of MMP9 in gingival crevicular fluid from diabetic patients with chronic periodontitis | Human | MMP8 | 4317 | matrix metallopeptidase 8 (neutrophil collagenase) | Non-surgical periodontal treatment was effective in reducing the levels of MMP8 in gingival crevicular fluid from diabetic patients with chronic periodontitis | Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607bp may be associated with severe chronic periodontitis in a Chinese population a polymorphism in the promoter region is associated with the severe chronic periodontitis phenotype in non-smokers Data suggest that the -1607 2G polymorphic allele of the MMP-1 gene could be associated with susceptibility to severe chronic periodontitis; the -519AG and GG genotypes may play a role in the outcome of periodontal therapy Title:MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population.|Association:Y|Conclusion:These results show that a polymorphism in the promoter region of MMP-1 gene is associated with the severe chronic periodontitis phenotype in non-smokers. | Human | LTA | 4049 | lymphotoxin alpha | Title:Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population.|Association:Not Found|Conclusion:Our data suggest that combined genotypes composed of the TNF-alpha and LT-alpha gene polymorphisms may influence the susceptibility to chronic periodontitis. We also showed that, comparing the two genes, the 1/1 genotype of the NcoI polymorphism in the first intron of the LT-alpha gene is a more informative marker and it may be one of the protective genetic factors against chronic periodontitis in our population. | Human | INPP5D | 3635 | inositol polyphosphate-5-phosphatase, 145kDa | Upregulated in oral mucosa during chronic periodontitis compared to its level during gingival health | Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Levels were higher in patients with chronic periodontitis compared with patients with gingivitis | Human | IL12RB2 | 3595 | interleukin 12 receptor, beta 2 | frequencies of variant alleles were significantly higher in aggressive periodontitis patients as compared with healthy controls or chronic periodontitis patients | Human | IL10 | 3586 | interleukin 10 | expression in chronic periodontitis lesions is associated with a distinct genotype This study failed to observe a significant difference in the -1082IL-10 single-nucleotide polymorphism between chronic periodontitis patients and controls | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | The -174IL-6 single-nucleotide polymorphism are associated with susceptibility to chronic periodontitis in the population studied IL-6 may play a role in modulating the inflammatory cascade of chronic periodontitis -572 G/C polymorphism may be one of the protective factors associated with lower susceptibility to chronic periodontitis | Human | IL4 | 3565 | interleukin 4 | The IL-4 gene locus (-590 C-->T polymorphism and 70 bp repeat polymorphism) contributes little to the interindividual susceptibility for adult periodontitis in a Korean population | Human | IL2RA | 3559 | interleukin 2 receptor, alpha | Results showed that patients with chronic periodontitis presented increased frequency of T lymphocytes and CD4+CD25+ T cells in the inflammatory infiltrate of gingival tissues |
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