Human | SLC12A8 | 84561 | solute carrier family 12, member 8 | Title:Systematic Linkage Disequilibrium Analysis of SLC12A8 at PSORS5 Confirms a Role in Susceptibility to Psoriasis Vulgaris.|Association:Not Found|Conclusion:We conclude that SLC12A8 is a susceptibility locus for PsV. In order to establish the exact nature of this association, efforts to identify the disease-causing variants are ongoing. SLC12A8 is a susceptibility locus for psoriasis vulgaris |
Human | LYNX1 | 66004 | Ly6/neurotoxin 1 | Up-regulated in psoriasis vulgaris |
Human | KIR2DL5A | 57292 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A | The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in psoriasis vulgaris cases compared with controls |
Human | DDX58 | 23586 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | RIG-I might operate not only as a RNA helicase but also as a mediator of the cytokine network in the inflammatory skin diseases, such as psoriasis vulgaris |
Human | TNF | 7124 | tumor necrosis factor | promoter polymorphisms associated with psoriasis vulgaris and psoriatic arthritis but not with pustulosis palmoplantaris study confirming the association between -238 G/A TNF-alpha promoter polymorphism & early-onset psoriasis vulgaris in northern Polish population suggests the -238A variant may contribute to predisposition to psoriasis vulgaris and to the disease phenotype |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta(1) gene polymorphism in codon 10 and 25 is not associated with susceptibility to psoriasis vulgaris, but may be important for the type of the disease |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | TAP1*D allele could lead to genetic susceptibility to psoriasis vulgaris in Poland |
Human | SLC14A1 | 6563 | solute carrier family 14 (urea transporter), member 1 | Title:A molecular genetic analysis of the Kidd blood group polymorphism in Taiwanese, Thais, and Filipinos.|Association:Not Found|Conclusion:The frequency of Jka and Jkb is 0.51 and 0.49 in Taiwanese, 0.44 and 0.56 in Thais, and 0.45 and 0.55 in Filipinos, respectively. |
Human | POU5F1 | 5460 | POU class 5 homeobox 1 | genetic association study shows that only a haplotype containing Cw*0602 is strongly associated with psoriasis vulgaris in Chinese; POU5F1 gene is unlikely to be the disease gene at PSORS1 locus |
Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | a marginal association between the NFKB1-94 ins/delATTG WW genotype and the increased psoriasis vulgaris risk and the association was more evident in the subgroups of onset age 20, male patients and sporadic patients in Chinese |
Human | KIR2DS1 | 3806 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 | The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in psoriasis vulgaris cases compared with controls |
Human | IRF2 | 3660 | interferon regulatory factor 2 | IFN-gamma-IRF system is involved in BPAG1 gene regulation in type-1 helper T-cell inflammatory skin conditions, such as psoriasis vulgaris |
Human | IRF1 | 3659 | interferon regulatory factor 1 | IFN-gamma-IRF system is involved in BPAG1 gene regulation in type-1 helper T-cell inflammatory skin conditions, such as psoriasis vulgaris |
Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | IL12B SNP is associated with susceptibility to atopic dermatitis and psoriasis vulgaris, presumably by affecting the Th1/Th2 balance |
Human | HLA-DRB1 | 3123 | | HLA-DRB1 haplotypes are associated in patients diagnosed with psoriasis vulgaris |
Human | HLA-DQA1 | 3117 | | HLA_DRB1 alleles are associated in patients diagnosed with psoriasis vulgaris |
Human | HLA-C | 3107 | | HLA-Cw6, overweight and higher waist-hip ratio are material risk factors of psoriasis vulgaris, especially the combined effects of HLA-Cw6 and BMI, WHR on psoriasis vulgaris in Chinese population protective gene telomeric to the HLA-C locus in psoriasis vulgaris |
Human | DARC | 2532 | Duffy blood group, atypical chemokine receptor | Duffy antigen may play a role at local level by binding locally produced chemokines in psoriasis vulgaris |
Human | FLG | 2312 | filaggrin | despite a markedly altered filaggrin expression in psoriatic skin, loss-of-function variants of the FLG gene are neither associated with psoriasis vulgaris nor with psoriatic arthritis |
Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | CTLA-4 gene, CT60A>G and +49A>G SNPs were studied in psoriasis vulgaris patients; the haplotype +49G, CT60G was significantly less frequent in the patient group with disease onset between the ages of 21 and 40 years than in controls |
Human | CDH13 | 1012 | cadherin 13 | T-cadherin acts as an endogenous negative regulator of keratinocyte proliferation and its inactivation is the cause for keratinocyte hyperproliferation in squamous cell carcinoma or in psoriasis vulgaris |
Human | C4B | 721 | complement component 4B (Chido blood group) | Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris |
Human | DST | 667 | dystonin | IFN-gamma-IRF system is involved in BPAG1 gene regulation in type-1 helper T-cell inflammatory skin conditions, such as psoriasis vulgaris |
Human | BCL2 | 596 | B-cell CLL/lymphoma 2 | Bcl-2 is expressed in dermal lymphocytes in lichen planus and psoriasis vulgaris |