Human | NCF1C | 654817 | neutrophil cytosolic factor 1C pseudogene | Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease |
Human | SFTPA1 | 653509 | surfactant protein A1 | SP-A is a major microbial permeablizing factor in lavage fluid and that oxidative stress inhibits the antibacterial activity of SP-A by a mechanism that includes oxidative modification and functional inactivation of the protein |
Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | Increased expression of NAD(P)H oxidase-p47phox and nuclear factor-kappaB p65 may contribute to endothelial oxidative stress with aging in humans |
Human | LOC648998 | 648998 | | Overweight and obese adults demonstrate increased vascular endothelial expression of NAD(P)H oxidase-p47(phox) linked to oxidative stress |
Human | NEIL2 | 252969 | nei endonuclease VIII-like 2 (E. coli) | YB-1 thus appears to have a novel regulatory role in NEIL2-mediated repair under oxidative stress |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | study reports that C9orf10 (designated Ossa for oxidative stress-associated Src activator) is a novel RNA-binding protein that guards cancer cells from oxidative stress-induced apoptosis by activation of Src family kinases [Ossa] |
Human | RDH12 | 145226 | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) | In most tissues RDH12 primarily contributes to the reduction of all-trans-retinaldehyde; however, in cells undergoing oxidative stress, such as photoreceptors, RDH12 might also play a role in detoxification of lipid peroxidation products |
Human | DCD | 117159 | dermcidin | Expression of dermcidin in human primary tumours appears highly variable and is not induced substantially by hypoxia/oxidative stress in cell line model systems |
Human | NEIL1 | 79661 | nei endonuclease VIII-like 1 (E. coli) | Oxidative stress-induced activation of NEIL1 appears to be involved in the feedback regulation of cellular repair activity needed to handle an increase in the level of oxidative base damage |
Human | SECISBP2 | 79048 | SECIS binding protein 2 | Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain |
Human | PINK1 | 65018 | PTEN induced putative kinase 1 | May be involved in apoptosi, oxidative stress, and development of Parkinson disease |
Human | NGB | 58157 | neuroglobin | human Ngb may be a novel oxidative stress-responsive sensor for signal transduction in the brain |
Human | HAMP | 57817 | hepcidin antimicrobial peptide | alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPalpha, which in turn leads to increased duodenal iron transport Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deaceetylase activity |
Human | RETN | 56729 | resistin | data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress |
Human | OXR1 | 55074 | oxidation resistance 1 | Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage |
Human | TMEM161A | 54929 | transmembrane protein 161A | adaptive response to oxidative stress (AROS)-29 gene has a functional role in the protection against oxidative stress |
Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | Nrf2-Keap1-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress |
Human | UPB1 | 51733 | ureidopropionase, beta | An altered homeostasis of beta-aminoisobutyric acid and/or increased oxidative stress might contribute to some of the clinical abnormalities encountered in patients with a beta-ureidopropionase deficiency |
Human | PIAS4 | 51588 | protein inhibitor of activated STAT, 4 | PIASy is the first SUMO ligase for NEMO whose substrate specificity seems to be controlled by IKK interaction, subcellular targeting and oxidative stress conditions |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | study demonstrates that oxidative stress induced by soluble cigarette smoke components potently inhibits the production of IL-12 and IL-23 by maturing dendritic cells |
Human | ANAPC11 | 51529 | anaphase promoting complex subunit 11 | Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress |
Human | GLRX2 | 51022 | glutaredoxin 2 | results suggest an important role for glutaredoxin 2 in protection and recovery from oxidative stress |
Human | NOX4 | 50507 | NADPH oxidase 4 | Thus Nox4 appears to produce superoxide in the nucleus of HUVECs, thereby regulating gene expression via a mechanism for oxidative stress response |
Human | SENP1 | 29843 | SUMO1/sentrin specific peptidase 1 | SENP1 may act as redox sensors and effectors modulating the desumoylation pathway and specific cellular responses to oxidative stress |
Human | NOX1 | 27035 | NADPH oxidase 1 | A study evaluating the relationship between phagocytic NADPH oxidase activity and oxidative stress and atherosclerosis in metabolic syndrome patients is presented |