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Details
Link-It Detail - Disease - Oxidative Stress
Debug Stats
  • ### Total Build Time: 552 ms 48.525 KB
  • CONCEPT_NAME gt=7 ms Completed: 6 ms rowSize= 330 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 824 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=2 ms Completed: 2 ms rowSize= 198 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=428 ms Completed: 428 ms rowSize= 14.713 KB
  • CONCEPT_GENES gt=106 ms Completed: 106 ms rowSize= 31.285 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.150 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Oxidative Stress C0242606
Definition (1)
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or "normal" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer's, and many others.
Semantic Types (1)
Cell or Molecular Dysfunction (T049)
Relationships (480)

Relation Types:
diso_​to_​anat : 77
diso_​to_​chem : 239
diso_​to_​diso : 93
diso_​to_​gene : 10
diso_​to_​phen : 7
diso_​to_​phys : 54


Relationships:
none : 458
biological_​process_​results_​from_​biological_​process : 3
chemical_​or_​drug_​initiates_​biological_​process : 1
gene_​plays_​role_​in_​process : 10
gene_​product_​plays_​role_​in_​biological_​process : 6
permuted_​term_​of : 1
use : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHYS3969img physiological aspects C0031843
DISO_to_PHYS3026img physiological aspects C0031843
DISO_to_CHEM2475img Antioxidants C0003402
DISO_to_CHEM1280img Antioxidants C0003402
DISO_to_PHYS845img Apoptosis C0162638
DISO_to_PHEN800img genetic aspects C0017399
DISO_to_CHEM735img Reactive Oxygen Species C0162772
DISO_to_DISO592img DNA Damage C0012860
DISO_to_ANAT581img Mitochondria C0026237
DISO_to_ANAT556img Liver C0023884
DISO_to_PHYS499img Apoptosis C0162638
DISO_to_PHYS491img Aging C0001811
DISO_to_DISO489img Inflammation C0021368
DISO_to_CHEM473img Extracts, Plant C0032081
DISO_to_ANAT466img Brain C0006104
DISO_to_ANAT417img Neurons C0027882
DISO_to_DISO388img DNA Damage C0012860
DISO_to_CHEM387img Reactive Oxygen Species C0162772
DISO_to_PHYS337img Signal Transduction C0037083
DISO_to_PHEN331img genetic aspects C0017399
DISO_to_ANAT328img Endothelium, Vascular C0014261
DISO_to_PHYS319img Aging C0001811
DISO_to_PHYS313img Lipid Peroxidation C0023775
DISO_to_ANAT309img Brain C0006104
DISO_to_ANAT307img Mitochondria C0026237
Genes (329)

Species:
human : 329
Page Size
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  Page 1 of 14
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanNCF1C654817neutrophil cytosolic factor 1C pseudogene
img GENERIF, Score=901, Pubmed Id: 16293794, UMLKSK CUI: C0242606
HumanSFTPA1653509surfactant protein A1
img GENERIF, Score=1000, Pubmed Id: 15890661, UMLKSK CUI: C0242606
HumanNCF1653361neutrophil cytosolic factor 1
img GENERIF, Score=901, Pubmed Id: 17478731, UMLKSK CUI: C0242606
HumanLOC648998648998
img GENERIF, Score=1000, Pubmed Id: 17242275, UMLKSK CUI: C0242606
HumanNEIL2252969nei endonuclease VIII-like 2 (E. coli)
img GENERIF, Score=1000, Pubmed Id: 17686777, UMLKSK CUI: C0242606
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
img GENERIF, Score=694, Pubmed Id: 19015244, UMLKSK CUI: C0242606
HumanRDH12145226retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
img GENERIF, Score=861, Pubmed Id: 15865448, UMLKSK CUI: C0242606
HumanDCD117159dermcidin
img GENERIF, Score=1000, Pubmed Id: 18594538, UMLKSK CUI: C0242606
HumanNEIL179661nei endonuclease VIII-like 1 (E. coli)
img GENERIF, Score=694, Pubmed Id: 16118226, UMLKSK CUI: C0242606
HumanSECISBP279048SECIS binding protein 2
img GENERIF, Score=1000, Pubmed Id: 16782878, UMLKSK CUI: C0242606
HumanPINK165018PTEN induced putative kinase 1
img GENERIF, Score=1000, Pubmed Id: 18272063, UMLKSK CUI: C0242606
HumanNGB58157neuroglobin
img GENERIF, Score=673, Pubmed Id: 12860983, UMLKSK CUI: C0242606
HumanHAMP57817hepcidin antimicrobial peptide
img GENERIF, Score=840, Pubmed Id: 16737972, UMLKSK CUI: C0242606
img GENERIF, Score=827, Pubmed Id: 18671304, UMLKSK CUI: C0242606
HumanRETN56729resistin
img GENERIF, Score=861, Pubmed Id: 12829623, UMLKSK CUI: C0242606
HumanOXR155074oxidation resistance 1
img GENERIF, Score=1000, Pubmed Id: 15060142, UMLKSK CUI: C0242606
HumanTMEM161A54929transmembrane protein 161A
img GENERIF, Score=1000, Pubmed Id: 16551573, UMLKSK CUI: C0242606
HumanUGT1A154658UDP glucuronosyltransferase 1 family, polypeptide A1
img GENERIF, Score=901, Pubmed Id: 17259171, UMLKSK CUI: C0242606
HumanUPB151733ureidopropionase, beta
img GENERIF, Score=901, Pubmed Id: 15385443, UMLKSK CUI: C0242606
HumanPIAS451588protein inhibitor of activated STAT, 4
img GENERIF, Score=1000, Pubmed Id: 16906147, UMLKSK CUI: C0242606
HumanIL23A51561interleukin 23, alpha subunit p19
img GENERIF, Score=1000, Pubmed Id: 18606709, UMLKSK CUI: C0242606
HumanANAPC1151529anaphase promoting complex subunit 11
img GENERIF, Score=1000, Pubmed Id: 15256223, UMLKSK CUI: C0242606
HumanGLRX251022glutaredoxin 2
img GENERIF, Score=1000, Pubmed Id: 14676218, UMLKSK CUI: C0242606
HumanNOX450507NADPH oxidase 4
img GENERIF, Score=734, Pubmed Id: 16324151, UMLKSK CUI: C0242606
HumanSENP129843SUMO1/sentrin specific peptidase 1
img GENERIF, Score=1000, Pubmed Id: 17704192, UMLKSK CUI: C0242606
HumanNOX127035NADPH oxidase 1
img GENERIF, Score=1000, Pubmed Id: 16380495, UMLKSK CUI: C0242606
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0242606Oxidative Stress0self