| Human | MIR21 | 406991 | microRNA 21 | miR-21 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer |
| Human | LOC391533 | 391533 | | Simultaneous up-regulation of sFlt-1 secretion by these cells under hypoxic conditions may prevent excessive up-regulation of vascular permeability |
| Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Rac1-dependent Noxs play a critical role in activating c-Src following hypoxia/reoxygenation injury[NADPH oxidase 2] |
| Human | LOC145908 | 145908 | | the combination of hypoxia and reoxygenation results in a G2 checkpoint response that is dependent on the tumor suppressor Chk2 and that this checkpoint response is essential for tumor cell adaptation to changes |
| Human | DCD | 117159 | dermcidin | Expression of dermcidin in human primary tumours appears highly variable and is not induced substantially by hypoxia/oxidative stress in cell line model systems |
| Human | EGLN3 | 112399 | egl-9 family hypoxia-inducible factor 3 | Chronic hypoxia not only increases the pool of PHDs but also overactivates the three PHD isoforms Mechanism underlying the regulation of PHD3 availability and activity in hypoxia by the E3 ligase Siah2 PHD-dependent oxygen-sensing recruits both the hypoxia-inducible factor (HIF) and ATF-4 systems PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor |
| Human | EGLN2 | 112398 | egl-9 family hypoxia-inducible factor 2 | PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor hypoxia releases repression of NFkappaB activity through decreased prolyl hydroxylase-dependent hydroxylation of IKKbeta |
| Human | CHRDL1 | 91851 | chordin-like 1 | Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis |
| Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | Hypoxia downregulates the concentration of endostatin in the culture media of human endometrial stromal cells Hypoxia down-regulates endostatin production by microvascular endothelial cells and pericytes |
| Human | SPHKAP | 80309 | SPHK1 interactor, AKAP domain containing | HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells |
| Human | BHLHE41 | 79365 | basic helix-loop-helix family, member e41 | DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2 |
| Human | PDIA2 | 64714 | protein disulfide isomerase family A, member 2 | PDI has a role in conferring resistance to apoptosis under hypoxia and a potential role in the oxygen-sensing apparatus |
| Human | HIF3A | 64344 | hypoxia inducible factor 3, alpha subunit | findings suggest that HIF-3alpha, as a member of the HIF system, is complementary rather than redundant to HIF-1alpha induction in protection against hypoxic damage in alveolar epithelial cells |
| Human | NGB | 58157 | neuroglobin | protein oxidation promotes stabilization of pentacoordinated species, thus favoring protein to adopt more reactive state & supporting existence of molecular mechanism where O2 is released under hypoxic conditions, suggesting O(2) storage function for Ngb |
| Human | HAMP | 57817 | hepcidin antimicrobial peptide | hypoxia lowers circulating prohepcidin concentrations in humans |
| Human | TRIB3 | 57761 | tribbles homolog 3 (Drosophila) | This protein, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia |
| Human | NDRG2 | 57447 | NDRG family member 2 | This study suggests that NDRG2 is a Hif-1 target gene and closely related with hypoxia-induced apoptosis in A549 cells |
| Human | KDM3A | 55818 | lysine (K)-specific demethylase 3A | Results show that many genes regulated by hypoxia and HIF-1alpha show patterns of induction with JMJD (Jumonji-domain containing)1A and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia These findings demonstrate that JMJD1A can be stimulated by hypoxia both in vitro and in vivo involving binding of HIF-1 to a specific HRE in the JMJD1A promoter |
| Human | HIF1AN | 55662 | hypoxia inducible factor 1, alpha subunit inhibitor | functional inactivation of HIF-alpha by stimulation of FIH-dependent p300 contributes to the YC-1-induced deregulation of hypoxia-induced genes FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor |
| Human | MNS1 | 55329 | meiosis-specific nuclear structural 1 | A rat homologous protein was among the the nuclear proteins that change in abundance or form in response to prolonged hypoxia in the rat kidney fibroblasts |
| Human | P4HTM | 54681 | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction |
| Human | EGLN1 | 54583 | egl-9 family hypoxia-inducible factor 1 | Accumulated EGLN1 in hypoxia acts as a negative-feedback mechanism to modulate HIF-1alpha target gene expression PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor Critical for normal regulation of hypoxia-inducible factor |
| Human | DDIT4 | 54541 | DNA-damage-inducible transcript 4 | These results demonstrate that hypoxic condition-and high cell density-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway co-transfection with antisense Sp1 oligonucleotide suggests that hypoxia induction of the RTP801 promoter is mediated by Sp1 |
| Human | ERRFI1 | 54206 | ERBB receptor feedback inhibitor 1 | |
| Human | CECR1 | 51816 | cat eye syndrome chromosome region, candidate 1 | findings show ADA2 is encoded by the CECR1 gene & belongs to novel family of ADA-related growth factors;ADA2 may be active in sites of inflammation during hypoxia & in areas of tumour growth where adenosine is elevated & extracellular pH is acidic |