Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes.|Association:Y|Conclusion:These results suggest that the CCR5 promoter 59029 A genotype may be an independent risk factor for diabetic nephropathy in patients with type 2 diabetes. |
Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | The kinetics of p47phox activation was investigated by comparing neutrophils from diabetic and healthy subjects, and the mechanism of hyperglycemia-induced changes was studied by using neutrophil-like HL-60 cells as a model |
Human | MAFA | 389692 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A | Under diabetic conditions, expression and/or activities of PDX-1 and MafA in beta-cells are reduced [REVIEW] |
Human | SLC30A8 | 169026 | solute carrier family 30 (zinc transporter), member 8 | The zinc transporter ZnT8 (Slc30A8), was targeted by autoantibodies in 60-80% of new-onset Type 1 diabetes (T1D) compared with <2% of controls and <3% type 2 diabetic and in up to 30% of patients with other autoimmune disorders with a T1D association |
Human | PLEKHH2 | 130271 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | PLEKHH2, which has mRNA and protein expression exclusively in the glomerulus, may be a genetic risk factor for susceptibility to diabetic nephropathy in the diabetic population |
Human | APOA5 | 116519 | apolipoprotein A-V | The APOA5-1131T-->C polymorphism is associated with both higher vitamin E concentrations and higher VLDL-TGs in diabetic patients |
Human | CNDP1 | 84735 | carnosine dipeptidase 1 (metallopeptidase M20 family) | Diabetic patients homozygous for CNDP1 are protected against diabetic nephropathy diabetic patients with the carnosinase CNDP1 gene Mannheim variant are less susceptible for nephropathy |
Human | FN3KRP | 79672 | fructosamine 3 kinase related protein | These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state |
Human | ABCG8 | 64241 | ATP-binding cassette, sub-family G (WHITE), member 8 | Increased NPC1L1 and lower ABCG5 abd ABCG8 may lead to increased cholesterol and sitosterol in chylomicron particles in diabetic patients |
Human | FN3K | 64122 | fructosamine 3 kinase | No significant correlation between FN3K activity and the levels of HbA1c, total glycated haemoglobin (GHb) and haemoglobin fructoselysine residues, either in the normoglycaemic or diabetic group |
Human | ACE2 | 59272 | angiotensin I converting enzyme 2 | Title:|Association:Not Found|Conclusion:Not Found |
Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Data show that human aldose reductase increases atherosclerosis in diabetic mice |
Human | RETN | 56729 | resistin | Resistin interferes with chemotactic movement and stimulation of oxidative burst of neutrophils, and therefore may contribute to the disturbed immune response in patients with increased resistin serum levels, e.g., uremic and diabetic subjects |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | concentration of obestatin circulating in blood was measured in the same cohort of women and was significantly lower in obese and obese diabetic women compared to control |
Human | SMR3A | 26952 | submaxillary gland androgen regulated protein 3A | Results suggest that hSMR3A can act as a marker for erectile dysfunction associated with both diabetic and non-diabetic etiologies |
Human | FGF21 | 26291 | fibroblast growth factor 21 | When administered daily for 6 wk to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon |
Human | CAPN10 | 11132 | calpain 10 | Fresh hope for the development of novel diabetic treatmentsutilizing either pharmacological activators that specifically target calpain-10, or through targeted calpain-10 gene therapy human lymphocytes express calpain-10 mRNA and protein, showing a similar expression between diabetic and control subjects, nevertheless in the diabetic group calpain activity was less glucose-sensitive |
Human | YWHAQ | 10971 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | In transgenic mice with cardiac specific overexpression of dominant negative 14-3-3 protein, 14-3-3 negatively regulates cardiac hypertrophy and fibrosis, possibly through controlling expression of protein kinase C beta 2 in the diabetic myocardium |
Human | PPARGC1A | 10891 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | No differences in mRNA levels of genes which mediate the transcriptional of mitochondrial biogenesis (PPARGC1A and NRF1) or in mitochondrial mass between diabetic and control myotubes |
Human | NOS1AP | 9722 | nitric oxide synthase 1 (neuronal) adaptor protein | Strong effects of NOS1AP variants in diabetic individuals suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval |
Human | ABCG1 | 9619 | ATP-binding cassette, sub-family G (WHITE), member 1 | The reduction in ABCG1 is associated with impairment in cholesterol efflux and may contribute to accelerated foam cell formation in diabetic patients |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Click here to display 8 evidence detail records. |
Human | PROZ | 8858 | protein Z, vitamin K-dependent plasma glycoprotein | Low plasma protein Z values were significantly associated with ischemic stroke except in diabetic subjects and females |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | The effect of hyperinsulinemia on TRAIL expression in diabetic and normal rats and in humans with type 2 diabetes mellitus is reported |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Lp-PLA2 activity and PLA2G7 A379V genotype were related to mediators of atherosclerosis in a diabetic study |