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Details
Link-It Detail - Disease - Medullary carcinoma of thyroid
Debug Stats
  • ### Total Build Time: 25 ms 47.738 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 358 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 688 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=19 ms Completed: 19 ms rowSize= 45.379 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.164 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Medullary carcinoma of thyroid C0238462
Definition (1)
A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.
Genes (67)

Species:
human : 65
mouse : 2
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseE2F31871E2F transcription factor 3
img NCI, Score=801, Pubmed Id: 12944480, UMLKSK CUI: C0238462
MouseDOK11796docking protein 1, 62kDa (downstream of tyrosine kinase 1)
img NCI, Score=801, Pubmed Id: 12087092, UMLKSK CUI: C0238462
HumanSCGB3A192304secretoglobin, family 3A, member 1
img GENERIF, Score=1000, Pubmed Id: 14614327, UMLKSK CUI: C0238462
HumanRXFP159350relaxin/insulin-like family peptide receptor 1
img NCI, Score=801, Pubmed Id: 15956746, UMLKSK CUI: C0238462
HumanNUPR126471nuclear protein, transcriptional regulator, 1
img GENERIF, Score=1000, Pubmed Id: 16101158, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 16101158, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 16101158, UMLKSK CUI: C0238462
HumanSCG27857secretogranin II
img NCI, Score=801, Pubmed Id: 3300386, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 9065020, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 1356907, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 3300386, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 9065020, UMLKSK CUI: C0238462
HumanVHL7428von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
img GENERIF, Score=884, Pubmed Id: 16707008, UMLKSK CUI: C0238462
HumanNKX2-17080
img NCI, Score=801, Pubmed Id: 11500234, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 10746684, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 10746684, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 10757334, UMLKSK CUI: C0238462
img GENERIF, Score=923, Pubmed Id: 15098009, UMLKSK CUI: C0238462
HumanTIMP17076TIMP metallopeptidase inhibitor 1
img NCI, Score=801, Pubmed Id: 9279566, UMLKSK CUI: C0238462
HumanTFF17031trefoil factor 1
img NCI, Score=801, Pubmed Id: 10757334, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 9664907, UMLKSK CUI: C0238462
HumanSYP6855synaptophysin
img NCI, Score=801, Pubmed Id: 2820344, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 3134611, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 3118696, UMLKSK CUI: C0238462
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img GENERIF, Score=923, Pubmed Id: 17145757, UMLKSK CUI: C0238462
HumanSSTR56755somatostatin receptor 5
img NCI, Score=801, Pubmed Id: 12063634, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 15077916, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 11344221, UMLKSK CUI: C0238462
HumanSSTR16751somatostatin receptor 1
img NCI, Score=801, Pubmed Id: 15077916, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 11344221, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 12063634, UMLKSK CUI: C0238462
img GENERIF, Score=694, Pubmed Id: 12359227, UMLKSK CUI: C0238462
HumanSPINK16690serine peptidase inhibitor, Kazal type 1
img NCI, Score=801, Pubmed Id: 6896146, UMLKSK CUI: C0238462
HumanSLC3A26520solute carrier family 3 (amino acid transporter heavy chain), member 2
img NCI, Score=801, Pubmed Id: 8185329, UMLKSK CUI: C0238462
img NCI, Score=801, Pubmed Id: 8185329, UMLKSK CUI: C0238462
HumanSAA16288serum amyloid A1
img NCI, Score=801, Pubmed Id: 949881, UMLKSK CUI: C0238462
HumanSAA@6287serum amyloid A1 cluster
img NCI, Score=801, Pubmed Id: 949881, UMLKSK CUI: C0238462
HumanRLN26019relaxin 2
img GENERIF, Score=717, Pubmed Id: 15956746, UMLKSK CUI: C0238462
HumanRLN16013relaxin 1
img GENERIF, Score=717, Pubmed Id: 15956746, UMLKSK CUI: C0238462
HumanRET5979ret proto-oncogene
Click here to display 27 evidence detail records.
HumanRBP35949retinol binding protein 3, interstitial
img NCI, Score=801, Pubmed Id: 1978560, UMLKSK CUI: C0238462
HumanPTPN65777protein tyrosine phosphatase, non-receptor type 6
img GENERIF, Score=717, Pubmed Id: 15746253, UMLKSK CUI: C0238462
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 12665651, UMLKSK CUI: C0238462
HumanPTGS15742prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 12665651, UMLKSK CUI: C0238462
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0238462Medullary carcinoma of thyroid0self