Genes (67)
Species: human : 65 mouse : 2 | |
Mouse | E2F3 | 1871 | E2F transcription factor 3 | E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. | Mouse | DOK1 | 1796 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | Because a high level of the JNK phosphorylation was observed in the cells expressing RET-MEN2B, its strong activation via Nck binding to Dok1 may be responsible for aggressive properties of medullary thyroid carcinoma developed in MEN 2B. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors | Human | RXFP1 | 59350 | relaxin/insulin-like family peptide receptor 1 | We investigated the expression of H1, H2 relaxin and INSL-3, mRNA and protein, and LGR7 and LGR8 transcripts in human C-cell hyperplasia, primary medullary thyroid carcinoma (MTC) tissues, MTC metastases, and the human MTC-TT and mouse MTC-M cell lines. | Human | NUPR1 | 26471 | nuclear protein, transcriptional regulator, 1 | p8 expression plays an important role in the progression of medullary thyroid carcinoma, but does not have an anti-apoptotic function In this study, p8 protein expression was investigated in human medullary thyroid carcinoma. Expression of p8 protein in medullary thyroid carcinoma. | Human | SCG2 | 7857 | secretogranin II | Chromogranin A and B and secretogranin II in medullary carcinomas of the thyroid. Secretogranin II (chromogranin C) has been demonstrated in normal and hyperplastic C cells of the thyroid as well as in medullary thyroid carcinoma. Normal and hyperplastic thyroid C-cells and 14 cases of medullary thyroid carcinoma were investigated immunohistochemically with antibodies against chromogranins A and B, secretogranin II, calcitonin and calcitonin gene-related peptide (CGRP). We have studied the presence of chromogranins A and B and secretogranin II in medullary carcinomas of the thyroid using the methods of immunoblotting and immunohistochemistry. Both by immunohistochemistry and immunoblotting it was found that C cells and medullary thyroid carcinomas contain substantially less secretogranin II when compared to chromogranins A and B. Secretoneurin, a biologically active protein endoproteolytically processed from secretogranin II, has been found to have a potent chemotactic activity towards monocytes. | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | somatic VHL gene alterations may not play a major role in tumorigenesis of MEN2A-associated medullary thyroid carcinoma | Human | NKX2-1 | 7080 | | Using a RT-PCR technique, complemented by Southern blot analysis, TTF-1 expression was detected in human C cells (two medullary thyroid carcinomas), but not in normal and adenomatous (four adenomas and three hyperplasia) parathyroid, and normal and adenomatous (six adenomas) pituitary tissues. Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas. The current study was undertaken to elucidate how TTF-1 is expressed in human C cells and medullary thyroid carcinomas (MTCs), and how this expression influences the functions and clinical behavior of these cells. All of the medullary thyroid carcinomas strongly expressed TTF-1. TTF-1 immunoreactivity favors a diagnosis of primary thyroid medullary carcinoma over laryngeal moderately differentiated neuroendocrine carcinoma | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | AIMS: Hyperplastic C-cells of the thyroid and medullary thyroid carcinomas (MTCs) were studied immunocytochemically for calcitonin, carcinoembryonic antigen (CEA), chromogranin A, matrix metalloproteinase (MMP)-2 and -9, and tissue inhibitor of metalloproteinase (TIMP)-1 and -2. | Human | TFF1 | 7031 | trefoil factor 1 | We examined TFF-1 expression using immunohistochemistry on formalin-fixed, paraffin-embedded sections of 49 gastrointestinal carcinoids; 15 pancreatic islet cell tumors; 21 paragangliomas; 8 medullary thyroid carcinomas; 7 small cell carcinomas of the uterine cervix; 4 prostate, 4 bladder, and 6 Merkel cell (primary cutaneous neuroendocrine) carcinomas; and 1 renal carcinoma No gastrointestinal carcinoid tumor, pancreatic islet cell tumor, paraganglioma, or Merkel cell carcinoma expressed TFF-1. TFF1 gene expression in human medullary thyroid carcinoma. | Human | SYP | 6855 | synaptophysin | Synaptophysin was consistently present in the tumor cells of pheochromocytomas (10/10), thyroid medullary carcinomas (8/8), and pancreatic islet cell tumors (6/6). Synaptophysin (protein p38) immunoreactivity has been detected immunohistochemically in neuroendocrine cells of the human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa as well as in 87 out of 93 neuroendocrine tumours investigated, including pheochromocytomas, chromaffin and non-chromaffin paragangliomas, ganglioneuromas, pituitary adenomas, thyroid medullary carcinomas, parathyroid adenomas, lung carcinoids and neuroendocrine carcinomas, pancreatic and gut endocrine tumours and cutaneous merkelomas. In the present study, metastases of several types of NE tumors, including medullary thyroid carcinoma, gastrinoma, insulinoma, small (oat) cell carcinoma of the lung, gastrointestinal carcinoid, and neuroblastoma, were examined for the presence of synaptophysin by immunocytochemistry, with the use of tissue sections as well as centrifuged cell suspensions and by immunoblotting of tumor proteins. | Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | The STAT3 pathway is involved in Cdk5-dependent proliferation of medullary thyroid cancer cells through Ser-727 phosphrylation | Human | SSTR5 | 6755 | somatostatin receptor 5 | Somatostatin (SRIH) analogs are commonly used to treat symptoms in medullary thyroid carcinoma (MTC), that expresses SRIH receptors (SSTR1 to SSTR5), as does the human MTC cell line TT. This effect can be hampered by concurrent somatostatin receptor 5 selective agonist treatment, which fails to influence TT cell proliferation, suggesting an antagonism between somatostatin receptors 5 and 2 agonists in medullary thyroid carcinoma cells. Somatostatin and its receptors (SSTR1 to SSTR5) are expressed in normal human parafollicular C cells and medullary thyroid carcinoma (MTC), but the role of SSTR subtypes in cell growth regulation is still not clear. | Human | SSTR1 | 6751 | somatostatin receptor 1 | On the other hand, somatostatin receptor 1 agonists inhibit proliferation, calcitonin secretion and calcitonin gene expression in parafollicular C cells, suggesting that analogs with enhanced somatostatin receptor 1 affinity and selectivity besides having great potentiality as pharmacological tools to control neoplastic growth, may also be used to reduce symptoms in patients with medullary thyroid carcinoma. Somatostatin and its receptors (SSTR1 to SSTR5) are expressed in normal human parafollicular C cells and medullary thyroid carcinoma (MTC), but the role of SSTR subtypes in cell growth regulation is still not clear. Somatostatin (SRIH) analogs are commonly used to treat symptoms in medullary thyroid carcinoma (MTC), that expresses SRIH receptors (SSTR1 to SSTR5), as does the human MTC cell line TT. selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | (2) A small complementary DNA (cDNA) plasmid library has been constructed in the PstI site of the plasmid pAT153, using total human thyroid medullary carcinoma poly(A)-containing RNA as the starting material. | Human | SLC3A2 | 6520 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | Furthermore, the biochemical study undertaken to identify anti-genetic protein using the Western blotting procedure demonstrated new HISL-19 antigen in medullary carcinoma of the thyroid, which is not recognized in benign endocrine tumor, and 4F2 antigen in anaplastic carcinoma. Furthermore, the biochemical study undertaken to identify anti-genetic protein using the Western blotting procedure demonstrated new HISL-19 antigen in medullary carcinoma of the thyroid, which is not recognized in benign endocrine tumor, and 4F2 antigen in anaplastic carcinoma. | Human | SAA1 | 6288 | serum amyloid A1 | Amyloid-related serum component (SAA)--studies in acute infections, medullary thyroid carcinoma, and postsurgery. | Human | SAA@ | 6287 | serum amyloid A1 cluster | Amyloid-related serum component (SAA)--studies in acute infections, medullary thyroid carcinoma, and postsurgery. | Human | RLN2 | 6019 | relaxin 2 | relaxin-like hormones appear to be present early during C-cell hyperplasia and potentially functional relaxin/INSL3 ligand-receptor systems are present in human medullary thyroid carcinoma tissues and cell lines | Human | RLN1 | 6013 | relaxin 1 | relaxin-like hormones appear to be present early during C-cell hyperplasia and potentially functional relaxin/INSL3 ligand-receptor systems are present in human medullary thyroid carcinoma tissues and cell lines | Human | RET | 5979 | ret proto-oncogene | Click here to display 27 evidence detail records. | Human | RBP3 | 5949 | retinol binding protein 3, interstitial | Furthermore, the locus that codes for a distinct phenotype, medullary thyroid carcinoma (MTC) with parathyroid tumors (PTs) and no pheochromocytomas (PHEOs) (referred to as MTC with PTs), in one of the families was closely linked to two markers, D10Z1 and RBP3, with lodscores of 2.86 and 3.54, respectively, at theta = 0. | Human | PTPN6 | 5777 | protein tyrosine phosphatase, non-receptor type 6 | SRIF inhibitory effects on thyroid medullary carcinoma cell proliferation are mediated, at least in part, by SHP-1, which acts through a MAPK-dependent mechanism | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cyclooxygenase 1 and cyclooxygenase 2 enzyme immunoreactivity is present only in the neoplastic C-cells of medullary carcinoma | Human | PTGS1 | 5742 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | cyclooxygenase 1 and cyclooxygenase 2 enzyme immunoreactivity is present only in the neoplastic C-cells of medullary carcinoma |
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