Mouse | IL23A | 51561 | interleukin 23, alpha subunit p19 | Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects. |
Mouse | LSM1 | 27257 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) | CaSm/gemcitabine chemo-gene therapy leads to prolonged survival in a murine model of pancreatic cancer. |
Mouse | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | In vivo, adenoviral delivery of TIMP1 or TIMP2 to nude mice harboring intraperitoneal human pancreatic cancers resulted in prolonged survival compared with control mice if the gene therapy was given early (P<.009 and P<.0293, respectively). |
Mouse | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | CONCLUSIONS: In a murine model for human pancreatic cancer, nearly all TIMP-1 and MMP-2 expression is tumor-derived (i.e., human). |
Mouse | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Delivery of the MnSOD gene may prove beneficial for suppression of pancreatic cancer growth. These results suggest that MnSOD may be a tumor suppressor gene in human pancreatic cancer. |
Mouse | S100P | 6286 | S100 calcium binding protein P | Click here to display 6 evidence detail records. |
Mouse | PAK1 | 5058 | p21 protein (Cdc42/Rac)-activated kinase 1 | Pak-1 showed a strong positive immunostaining to well- and moderately-differentiated tubular duct cell carcinoma of the pancreas but neither to poorly-differentiated nor to other non-tubular pancreatic carcinomas. |
Mouse | FLT1 | 2321 | fms-related tyrosine kinase 1 | Single i.v. injections of viruses encoding soluble forms of Flk1 or Flt1 resulted in approximately 80% inhibition of preexisting tumor growth in murine models involving both murine (Lewis lung carcinoma, T241 fibrosarcoma) and human (BxPC3 pancreatic carcinoma) tumors. |
Mouse | DUSP1 | 1843 | dual specificity phosphatase 1 | Down-regulation of MKP-1 resulted in decreased anchorage-dependent and -independent growth of pancreatic cancer cells, and decreased tumorigenicity in a nude mouse tumor model. |
Mouse | CCKBR | 887 | cholecystokinin B receptor | Click here to display 5 evidence detail records. |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Click here to display 6 evidence detail records. |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Click here to display 3 evidence detail records. |
Human | BCL9L | 283149 | B-cell CLL/lymphoma 9-like | Human BCL9L mRNA was expressed in fetal brain, adult lung, amygdala, eye, prostate, and also in several types of tumors including pancreatic cancer, prostate cancer, head and neck tumor and embryonal tumor. |
Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | Tumor cells expressing cell surface heparanase, CHO cells lacking membranal heparan sulfate and glypican-1-suppressed pancreatic cancer cells manifest reduced recognition by NKp30 and NKp46 and are lysed to a lesser extent by NK cells. |
Human | ARHGAP27 | 201176 | Rho GTPase activating protein 27 | ARHGAP27 mRNA was expressed in germinal center B cell, spleen, chronic lymphocytic leukemia, pancreatic cancer, and lung cancer. |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Elevated postoperative serum CA19-9 level is associated with reduced survival and early development of distant metastatic disease in pancreatic cancer |
Human | TMEM30B | 161291 | transmembrane protein 30B | Human CDC50A mRNA was expressed in embryonic stem (ES) cells, placenta, brain and chondrosarcoma, while CDC50B mRNA was expressed in pancreatic islet, kidney, prostate as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer. |
Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | SLC5A8 may function as a tumor suppressor gene whose silencing may contribute to carcinogenesis and progression of pancreatic cancer |
Human | GATA5 | 140628 | GATA binding protein 5 | While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far |
Human | OSR1 | 130497 | odd-skipped related 1 (Drosophila) | OSR1 mRNA was significantly up-regulated in a pancreatic cancer cell line MIA PaCa-2, and was weakly expressed in gastric cancer cell lines OKAJIMA, MKN45, pancreatic cancer cell lines PANC-1, BxPC-3, AsPC-1, PSN-1, Hs766T, and esophageal cancer cell line TE10. |
Human | MMP21 | 118856 | matrix metallopeptidase 21 | MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer |
Human | DCD | 117159 | dermcidin | This study determined the nutritional characteristics of patients with pancreatic cancer who excrete PIF in the urine and investigated the relationship between PIF and the acute-phase protein response. A novel protein, proteolysis-inducing factor (PIF), has been isolated from the urine of patients with pancreatic cancer and is capable of inducing muscle proteolysis in vitro. |
Human | OSBPL5 | 114879 | oxysterol binding protein-like 5 | OSBPL5 is relatd to invasion and poor prognosis in pancreatic cancer |
Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Click here to display 3 evidence detail records. |
Human | MYLK3 | 91807 | myosin light chain kinase 3 | Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines. |