Human | ANKK1 | 255239 | ankyrin repeat and kinase domain containing 1 | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | TPPP | 11076 | tubulin polymerization promoting protein | p25 and cyclin-dependent kinase 5 play important roles as mediators of dopamine and glutamate in the neurotoxicity associated with Huntington's disease |
Human | SLC19A2 | 10560 | solute carrier family 19 (thiamine transporter), member 2 | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | HYOU1 | 10525 | hypoxia up-regulated 1 | Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways |
Human | BCL2L11 | 10018 | BCL2-like 11 (apoptosis facilitator) | Bim is an essential mediator of amyloid-beta-induced neurotoxicity |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | The Wnt pathway substantially contributes to TRAIL-related neurotoxicity in SH-SY5Y human neuroblastoma cells |
Human | TXN | 7295 | thioredoxin | Abeta neurotoxicity might be mediated by oxidation of GRX1 or TRX1 and subsequent activation of the ASK1 cascade |
Human | TTR | 7276 | transthyretin | TTR can bind to the plasma membrane and cause a change in membrane fluidity which may be the cause of neurotoxicity |
Human | TRPC1 | 7220 | transient receptor potential cation channel, subfamily C, member 1 | role in inhibiting 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells |
Human | TKT | 7086 | transketolase | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | TH | 7054 | tyrosine hydroxylase | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | both macroautophagy and the proteasome are important for the reduction of mutant SOD1-mediated neurotoxicity in amyotrophic lateral sclerosis Thus, relative to wild-type microglia, mSOD1(G93A) microglia were more neurotoxic and induced more motoneuron injury than similarly treated wild-type microglia |
Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | Endocytic pathway is involoved in alpha-synuclein-induced neurotoxicity in transgenic C. elegans neurotoxicity is a mechanism for selective neurodegeneration in Parkinson disease |
Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | SLC2A1 | 6513 | solute carrier family 2 (facilitated glucose transporter), member 1 | GLUT1 may be a major pathway uptake of both inorganic and methylated arsenicals in erythrocytes or the epithelial cells of the blood-brain barrier, contributing to arsenic-related cardiovascular problems and neurotoxicity |
Human | RYR1 | 6261 | ryanodine receptor 1 (skeletal) | INFERRED, Score=800, UMLKSK CUI: C0235032 |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | NMDA neurotoxicity is mediated by S-nitrosylation/activation of COX-2 |
Human | PRNP | 5621 | prion protein | These data highlight the underlying mechanisms of C-transmembrane form of prion protein [(Ctm)PrP] biogenesis and neurotoxicity and reinforce the idea that (Ctm)PrP may serve as the proximate cause of neuronal death in certain prion disorders |
Human | MAPK11 | 5600 | mitogen-activated protein kinase 11 | Neurotoxicity of pneumolysin depends on activation of p38 mitogen-activated protein kinase |
Human | SEPT4 | 5414 | septin 4 | The Sept4 may be involved in PD as a dual susceptibility factor, as its insufficiency can diminish dopaminergic neurotransmission and enhance alpha-synuclein neurotoxicity |
Human | SEPT5 | 5413 | septin 5 | CDCrel-1 overexpression exerts dopamine-dependent neurotoxicity and may contribute to the development of autosomal-recessive juvenile parkinsonism |
Human | PARK2 | 5071 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | Parkin Arg275Trp mutant expression mediates pathogenic outcomes and suggests the interesting possibility that select parkin mutations may directly exert neurotoxicity in vivo |
Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | decrease in Tat-induced neurotoxicity and HIV transactivation is due to Tat's enzymatic cleavage by MMP-1 |
Human | MAPT | 4137 | microtubule-associated protein tau | Tau is essential to beta -amyloid-induced neurotoxicity |
Human | HTT | 3064 | huntingtin | the intrabody reduces the specific neurotoxicity of cytoplasmic mutant huntingtin and its associated neurological symptoms by preventing the accumulation of mutant huntingtin in neuronal processes and promoting its clearance in the cytoplasm |