Human | GPR132 | 29933 | G protein-coupled receptor 132 | Activity of the human G2A receptor is less sensitive to pH fluctuations as measured by inositol phosphate and cAMP accumulation |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of SOD |
Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | study identified a new family with SNCA duplication who developed parkinsonism, visual hallucination, and cognitive fluctuation Fluctuations in consciousness |
Human | SNCB | 6620 | synuclein, beta | Fluctuations in consciousness |
Human | SELPLG | 6404 | selectin P ligand | A new method for determining receptor-ligand association/dissociation events across the interface of two surfaces (two-dimensional binding) by monitoring abrupt decrease/resumption in thermal fluctuations of a biomembrane force probe |
Human | PARK2 | 5071 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | patients with a single parkin mutation had significantly later and more asymmetrical onset and more frequent levodopa-induced fluctuations and dystonia than patients with two mutations |
Human | NEDD8 | 4738 | neural precursor cell expressed, developmentally down-regulated 8 | Data show that NEDD8 and ubiquitin have similar conformational fluctuation in the evolutionary conserved enzyme-binding region and contain a structurally similar locally disordered conformer (I) in equilibrium with the basic folded conformer (N) |
Human | HTR1A | 3350 | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Fluctuation in the level of SPS is a risk factor for the onset of flare in SLE patients with major renal manifestations when it occurs on the background of a stress-related susceptibility gene (the 5-HT1A -1019 G allele) |
Human | HLA-G | 3135 | | Intrathecal production and fluctuations in CSF and serum concentrations of HLA-I were reciprocal in multiple sclerosis fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in multiple sclerosis through Fas/FasL-mediated mechanisms |
Human | HLA-C | 3107 | | Intrathecal production and fluctuations in CSF and serum concentrations of sHLA-I were reciprocal in multiple sclerosis |
Human | HBB | 3043 | hemoglobin, beta | using differential interference contrast microscopy; spontaneous, thermal fluctuations in fiber shape are measured to obtain bending moduli (kappa) and persistence lengths (lambda(p)) |
Human | ELANE | 1991 | elastase, neutrophil expressed | 15 to 35-day cyclic fluctuations in formed elements of blood |
Human | CST3 | 1471 | cystatin C | molecular dynamics simulations were conducted to investigate the conformational fluctuations of monomeric L68Q and wild-type cystatin Cs at various combinations of temperature (300 and 500K) & pH (2 & 7) to gain insights into the domain swapping mechanism |
Human | CCNT1 | 904 | cyclin T1 | fluctuation in CycT1 levels during human macrophage differentiation may be involved in the regulation of HIV-1 replication |
Human | HCN2 | 610 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Noise analysis on macroscopic currents revealed fluctuations whose magnitudes were systematically larger than predicted from the actual single channel current size, consistent with cooperativity between single HCN channels |
Human | FAS | 355 | Fas cell surface death receptor | fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in multiple sclerosis through Fas/FasL-mediated mechanisms |
Human | KLK3 | 354 | kallikrein-related peptidase 3 | only minor fluctuations of serum PSA concentrations are observed in healthy pre- and post-menopausal women, while serum level is higher in polycystic ovary syndrome |
Human | APP | 351 | amyloid beta (A4) precursor protein | Amyloid assembly may involve fluctuation between a fast-growing and a blocked state in which the fibril is kinetically trapped because of intrinsic structural feature |
Human | AMH | 268 | anti-Mullerian hormone | Fluctuations observed are smaller than intercycle variability and thus are not clinically relevant as far as AMH measurements for clinical purposes are concerned |