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Genes (12)
Species: human : 12 | |
Human | MAML2 | 84441 | mastermind-like 2 (Drosophila) | Malignant salivary gland tumors can arise from a t(11;19) translocation that fuses 42 residues from Mect1/Torc1, a cyclic AMP (cAMP)/cAMP-responsive element binding protein (CREB)-dependent transcriptional coactivator, with 982 residues from Maml2, a NOTCH receptor coactivator. | Human | TSC22D1 | 8848 | TSC22 domain family, member 1 | Click here to display 17 evidence detail records. | Human | TP63 | 8626 | tumor protein p63 | CONCLUSIONS.: Hence, p63 and p73 expression is retained in both benign and malignant salivary gland tumors with basaloid or myoepithelial differentiation. In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors. PURPOSE: The purpose of this study was to determine the extent of p63 immunoreactivity in the malignant salivary gland neoplasms adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) and to compare this to the expression of this marker in the benign salivary gland tumors canalicular adenoma and basal cell adenoma. To determine the association between the expression of p63 gene isoforms (TA and DeltaN) and salivary gland tumorigenesis, we performed reverse transcription-polymerase chain reaction analysis of these markers in 71 benign and malignant salivary gland neoplasms. | Human | RBL2 | 5934 | retinoblastoma-like 2 (p130) | These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers. | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines | Human | PLAG1 | 5324 | pleiomorphic adenoma gene 1 | In contrast, PLAG1 was overexpressed in only 2 of 11 malignant salivary gland tumors analyzed, which suggests that, at least in salivary gland tumors, PLAG1 activation preferentially occurs in benign tumors. Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. Our data indicate that the presence or absence of PLAG1 expression is not an unequivocal marker for the differential diagnosis of benign versus malignant salivary gland tumors, and that a simple de novo activation of this gene does not fully explain the involvement of this gene in salivary gland tumors. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | CONCLUSION: p16 and nm23 genes may play an important role in different sides in salivary gland tumorigenesis and the reduce of the expression of p16 and nm23 genes may contribute to the generation of malignant salivary gland tumors. CONCLUSION: p16 and nm23 genes may play an important role in different sides in salivary gland tumorigenesis and the reduce of the expression of p16 and nm23 genes may contribute to the generation of malignant salivary gland tumors. | Human | MUC7 | 4589 | mucin 7, secreted | The aim of this study was to investigate the expression of mucins (MUC1, MUC2, MUC4, MUC5AC, MUCB, MUC6, MUC7) in mucoepidermoid carcinomas, the most frequent malignant tumor of salivary glands. | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | The aim of this study was to investigate the expression of mucins (MUC1, MUC2, MUC4, MUC5AC, MUCB, MUC6, MUC7) in mucoepidermoid carcinomas, the most frequent malignant tumor of salivary glands. | Human | CD151 | 977 | CD151 molecule (Raph blood group) | CD151 forms a functional complex with c-Met in human salivary gland cancer cells. | Human | BMP6 | 654 | bone morphogenetic protein 6 | To study the possible involvement of BMP-6 in normal and neoplastic human salivary glands, we compared its mRNA and protein expression in 4 fetal and 15 adult salivary glands and in 22 benign and 32 malignant salivary gland tumors. Other benign and malignant salivary gland tumors lacked BMP-6 immunoreactivity, except in areas of squamous differentiation. | Human | AKT1 | 207 | v-akt murine thymoma viral oncogene homolog 1 | The Akt isoforms are required for the HGF-stimulated invasive growth of human salivary gland cancer cells |
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