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Genes (24)
Species: human : 24 | |
Human | IKZF1 | 10320 | IKAROS family zinc finger 1 (Ikaros) | In contrast to children, adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms | Human | MVP | 9961 | major vault protein | Lung resistance protein (LRP) gene expression in adult acute myeloid leukemia: a critical evaluation by three techniques. Therefore, we examined MDR1, MRP1 and LRP gene expression at diagnosis in 331 adult AML patients in the context of other known prognostic factors, such as age, disease status, cytogenetics and FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication mutational status. | Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | MRP3, BCRP, and P-glycoprotein have roles in progression of adult acute myeloid leukemia | Human | ABCC3 | 8714 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | MRP3, BCRP, and P-glycoprotein have roles in progression of adult acute myeloid leukemia | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. | Human | WT1 | 7490 | Wilms tumor 1 | The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia | Human | PTPN11 | 5781 | protein tyrosine phosphatase, non-receptor type 11 | Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia. correlation of PTPN11 mutations with NPM1 mutations and FLT3/ITD among adult AML patients Sequencing of PTPN11 from 13 different human neoplasms including breast, lung, gastric, and neuroblastoma tumors and adult AML and acute lymphoblastic leukemia revealed 11 missense mutations. | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | MRP3, BCRP, and P-glycoprotein have roles in progression of adult acute myeloid leukemia | Human | ORC5 | 5001 | origin recognition complex, subunit 5 | The ORC5L gene encoding a subunit of the human origin recognition complex (ORC) maps to chromosome band 7q22, a region frequently deleted in adult acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). | Human | NUP98 | 4928 | nucleoporin 98kDa | Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. Major form of NUP98/HOXC11 fusion in adult acute myeloid leukemia with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). | Human | NPM1 | 4869 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | NPM1 mutations represent a common genetic abnormality in adult acute myeloid leukemia and appears to identify patients with improved response toward treatment correlation of PTPN11 mutations with NPM1 mutations and FLT3/ITD among adult AML patients | Human | MYH11 | 4629 | myosin, heavy chain 11, smooth muscle | NPM1 gene mutations are the most frequent genetic lesion in the 60% of adult acute myeloid leukemias (AMLs) with normal karyotype and no evidence of typical fusion genes (BCR/ABL1, PML/RARA, AML1/ETO, CBFB/MYH11, DEK/CAN). | Human | MPL | 4352 | myeloproliferative leukemia virus oncogene | CONCLUSION: These data suggest that c-mpl expression is an adverse prognostic factor for treatment outcome in adult AML that must be considered in the analysis of clinical studies using thrombopoietin in AML. | Human | MLL | 4297 | | An MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone has been reported in a case of adult acute myeloid leukemia | Human | HOXC13 | 3229 | homeobox C13 | Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). | Human | HOXC11 | 3227 | homeobox C11 | Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. | Human | HOXA9 | 3205 | homeobox A9 | Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia. | Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | Polymorphic variants in xenobiotic-metabolism genes including CYP1A1 and GSTT1 may increase the risk of adult AML, particularly when present together Deletions have a negative prognostic value in adult acute myeloid leukemia | Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Deletions have a negative prognostic value in adult acute myeloid leukemia | Human | FLT3 | 2322 | fms-related tyrosine kinase 3 | FLT3/ITD is less common in pediatric than in adult acute myeloid leukemia and FLT3/ITD is a strong and independent adverse prognostic factor, and high ratios between mutant and WT-FLT3 further compromise prognosis high frequency of FLT3 mutations in adult acute myelocytic leukemia without recurrent cytogenetic translocations correlation of PTPN11 mutations with NPM1 mutations and FLT3/ITD among adult AML patients | Human | CDKN2B | 1030 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | In this study, we used sodium bisulfite sequencing to obtain a complete map of the 5-methylcytosine status of 80 CpGs covering approximately 900 bp in the 5; p15 CpG island, and 53 CpGs covering approximately 700 bp in the 5; p16 CpG island in the hematopoietic cell lines HL60, KG-1, and KG-1a, two normal human bone marrow samples (NBM), and eight cytosine arabinoside (ara-C)-resistant adult acute myeloid leukemia (AML) patients. | Human | CDH17 | 1015 | cadherin 17, LI cadherin (liver-intestine) | CDH16 was localized to 8q22.1, a region exhibiting loss of heterozygosity in adult acute myeloid leukemia. | Human | CDH16 | 1014 | cadherin 16, KSP-cadherin | CDH16 was localized to 8q22.1, a region exhibiting loss of heterozygosity in adult acute myeloid leukemia. | Human | BCL2L1 | 598 | BCL2-like 1 | The prognostic value of Bcl-XL gene expression for remission induction is influenced by cytogenetics in adult acute myeloid leukemia. |
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