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Genes (16)
Species: human : 16 | |
Human | NSD1 | 64324 | nuclear receptor binding SET domain protein 1 | Here, we report a patient with a microdeletion in nuclear receptor SET-domain-containing protein (NSD1) and a previously undescribed intracranial ganglioglioma. Ganglioglioma in a Sotos syndrome patient with an NSD1 deletion. Ganglioglioma in a Sotos syndrome patient with an NSD1 deletion. | Human | PTBP2 | 58155 | polypyrimidine tract binding protein 2 | In this paper we examine the specific cellular distribution of PTB expression in normal brain (n = 2) and tumors of various types (low-grade astrocytoma, n = 2; anaplastic astrocytoma, n = 2; glioblastoma, n = 4; medulloblastoma, n = 4; central neurocytoma, n = 2; dysplastic gangliocytoma, n = 1; ganglioglioma, n = 1; paraganglioma, n = 1). | Human | NES | 10763 | nestin | Nestin expression in ganglioglioma. | Human | MVP | 9961 | major vault protein | In gangliogliomas, western blot analysis showed a consistent increase in major vault protein expression compared with control cortex | Human | CDK5R1 | 8851 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | significantly lower levels of cyclin-dependent kinase 5, regulatory subunit 1 (p35) gene transcripts were detected in gangliogliomas compared to controls | Human | TSC2 | 7249 | tuberous sclerosis 2 | Title:A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas.|Association:Y|Conclusion:The rare allele of the TSC2 gene emerges as a candidate for a predisposing factor for the formation of sporadic gangliogliomas. | Human | TP53 | 7157 | tumor protein p53 | Study reports the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component | Human | SYP | 6855 | synaptophysin | Synaptophysin staining for ganglioglioma. The tumor was removed surgically and found to be a ganglioglioma composed of pilocytic glial cells (immunoperoxidase-positive for glial fibrillary acid protein) and neurons (immunoperoxidase-positive for neuron specific enolase, synaptophysin, and neurofilament). The significance of immunocytochemical markers, synaptophysin and neurofilaments in diagnosis of ganglioglioma. The files of the Division of Neuropathology of New York University Medical Center contained 45 tumors that had been diagnosed as ganglioglioma, of which 42 were verified by synaptophysin; three cases were reclassified, two as astrocytomas and one as a gangliocytic paraganglioma. Intense immunoreactivity for both synapsin I and synaptophysin was observed in tumors containing well-differentiated neurons (gangliocytoma, ganglioglioma, neurocytoma). Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. In our study, the reaction with synaptophysin and NFP was performed on fragments of normal frontal lobe, pons and cerebellum as well as on fragments of post-operation tumor diagnosed as ganglioglioma. For immunocytochemical identification of neoplastic neurons in ganglioglioma as well as other tumors with neuronal differentiation the authors propose a panel of well-characterized monoclonal antibodies against neurofilament polypeptides, synaptophysin, and chromogranin A to support the histomorphologic diagnoses. Immunohistochemistry showed the neurons of the ganglioglioma to be positive for class III beta-tubulin, synaptophysin, and chromogranin A, whereas the astrocytic cells stained only for glial fibrillary acidic protein. Immunohistochemical double labeling with antibodies to synaptophysin, beta-tubulin isotype III, GFAP and CD44H demonstrated neoplastic neurons and astrocytes in the ganglioglioma, while coexpression of glial and neuronal markers was found in a subset of PXA tumor cells variously showing giant cell or spindle cell morphology. | Human | SYN1 | 6853 | synapsin I | Intense immunoreactivity for both synapsin I and synaptophysin was observed in tumors containing well-differentiated neurons (gangliocytoma, ganglioglioma, neurocytoma). | Human | PTBP1 | 5725 | polypyrimidine tract binding protein 1 | In this paper we examine the specific cellular distribution of PTB expression in normal brain (n = 2) and tumors of various types (low-grade astrocytoma, n = 2; anaplastic astrocytoma, n = 2; glioblastoma, n = 4; medulloblastoma, n = 4; central neurocytoma, n = 2; dysplastic gangliocytoma, n = 1; ganglioglioma, n = 1; paraganglioma, n = 1). | Human | RELN | 5649 | reelin | The reelin signaling and tuberin/insulin growth receptor pathways have recently been implicated in ganglioglioma development. | Human | DAB1 | 1600 | Dab, reelin signal transducer, homolog 1 (Drosophila) | significantly lower levels of disabled homolog 1 gene transcripts were detected in gangliogliomas compared to controls | Human | CDK1 | 983 | cyclin-dependent kinase 1 | data strongly argue against mutational events of CDK1, cyclinB1 and cyclinA2 to play a role in gangliogliomas or focal cortical dysplasia | Human | CCNB1 | 891 | cyclin B1 | data strongly argue against mutational events of CDK1, cyclinB1 and cyclinA2 to play a role in gangliogliomas or focal cortical dysplasia | Human | CCNA2 | 890 | cyclin A2 | data strongly argue against mutational events of CDK1, cyclinB1 and cyclinA2 to play a role in gangliogliomas or focal cortical dysplasia | Human | AQP4 | 361 | aquaporin 4 | AQP4 immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunoreactivity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung. |
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