Genes (98)
Species: human : 98 | |
Human | LOC100507436 | 100507436 | | Carriership of the MICA 5.1 allele was associated with resistance against cholangiocarcinoma | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | In this study, we examined the expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins in cholangiocarcinoma (CC) and biliary epithelial dysplasia. | Human | INHBE | 83729 | inhibin, beta E | Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells. A well characterized human cholangiocarcinoma (CC) cell line, SG231, was compared with primary cultures of normal human biliary epithelial cells (BECs) for alterations in interleukin 6 (IL-6) and hepatocyte growth factor (HGF)-mediated stimulation and transforming growth factor beta1 (TGF-beta1) and activin A-mediated inhibition of growth. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | The cholangiocarcinomas associated with cirrhosis and the cholangiocarcinoma elements of combined hepatocellular-cholangiocellular carcinoma rarely expressed MUC3 and MUC5AC, but the cholangiocarcinomas not associated with cirrhosis frequently expressed these apomucins. To characterize such cholangiocarcinomas, we examined immunohistochemically the expression of MUC3, MUC5AC, MUC6, and MUC7 apomucins in hepatic tissue specimens from 4 patients with cholangiocarcinoma and viral cirrhosis, 24 patients with cholangiocarcinoma without cirrhosis, and 16 patients with combined hepatocellular-cholangiocellular carcinoma. In this study, we examined the expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins in cholangiocarcinoma (CC) and biliary epithelial dysplasia. | Human | LAPTM4B | 55353 | lysosomal protein transmembrane 4 beta | LAPTM4B-35 positively expressed in a great portion of extrahepatic cholangiocarcinoma and might be a novel molecular maker of progression, invasiveness and poor prognosis | Human | UGT1A10 | 54575 | UDP glucuronosyltransferase 1 family, polypeptide A10 | UGT1A10, a newly discovered UGT1A gene product, is expressed only in biliary and not hepatocellular tissue and is also significantly down-regulated in cholangiocellular carcinoma. | Human | LEF1 | 51176 | lymphoid enhancer-binding factor 1 | Overexpression of cPLA(2)alpha in human cholangiocarcinoma cells induced the binding of PPARdelta to beta-catenin and increased their association with the TCF/LEF response element | Human | GNMT | 27232 | glycine N-methyltransferase | Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma | Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | single nucleotide polymorphisms associated with an increased risk of cholangiocarcinoma: rs11053781 and rs2617167 NKG2D polymorphisms, previously associated with cholangiocarcinoma, do not seem to confer risk of sporadic colorectal cancer (CRC) | Human | ANXA10 | 11199 | annexin A10 | We showed that ANXA10 mRNA was expressed in adult liver and hepatocellular carcinoma (HCC), but not in multiple adult and fetal tissues, cholangiocarcinoma, and several other common carcinomas. | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | RASSF1A which we have been searching for at 3p21.3 may be one of the key tumor suppressor gene and play an important role in the pathogenesis of extrahepatic cholangiocarcinoma The high incidence of 3p loss and RASSF1A promoter hypermethylation detected may have implications for this tumor suppressor gene in the malignant progression of cholangiocarcinoma | Human | CHL1 | 10752 | cell adhesion molecule L1-like | This study analyzed new cell lineage markers for the differential diagnosis between hepatocellular carcinoma (HCC) and cholangiocarcinoma (ChC), as well as the potential pathways of cell-cell and cell-extracellular matrix interactions of neoplastic liver cells during tumor spread and invasion, by comparing the expression of (VLA) integrins, vitronectin receptor, and neural cell adhesion molecule in normal, inflamed, and neoplastic human liver biopsies. | Human | GDF15 | 9518 | growth differentiation factor 15 | Serum MIC-1 levels were significantly higher in patients with pancreatic ductal adenocarcinoma (mean +/- SD, 2428 +/- 2324 pg/ml) and in patients with ampullary and cholangiocellular carcinomas (2123 +/- 2387 pg/ml) than in those with benign pancreatic neoplasms (940 +/- 469 pg/ml), chronic pancreatitis (1364 +/- 1236 pg/ml), or in healthy controls (546 +/- 262 pg/ml). Serum MIC-1 levels were determined by ELISA in 80 patients with pancreatic adenocarcinomas, in 30 patients with ampullary and cholangiocellular carcinomas, in 42 patients with benign pancreatic tumors, in 76 patients with chronic pancreatitis, and in 97 healthy control subjects. | Human | SLC9A3R1 | 9368 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | In dominant-negative transfection studies, patch clamp analysis of Mz-ChA1 cholangiocarcinoma cells showed that expression of the PDZ1 domain of EBP50 selectively decreased the endogenous cAMP-mediated Cl secretory response. | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | BACKGROUND/AIMS: The tumor-associated antigen, RCAS1, has been reported to be expressed in various types of cancer, including cholangiocarcinoma. Clinical significance of serum RCAS1 levels detected by monoclonal antibody 22-1-1 in patients with cholangiocellular carcinoma. RCAS1, a useful serum marker to predict the recurrence of cancer: two cases of cholangiocarcinoma and pancreatic cancer. Serum RCAS 1 levels are also elevated in a high percentage of patients with intra-hepatic cholangiocarcinoma. RCAS1 production by cell lines was investigated by flow cytometry, enzyme-linked immunosorbent assay, and reverse transcription-polymerase chain reaction.RESULTS: All cholangiocarcinoma cell lines examined clearly expressed RCAS1 at both the protein and RNA level. | Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma | Human | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | WISP1v-mediated signaling is involved in the generation of invasive cellular properties and leads to progression of cholangiocarcinoma | Human | CFLAR | 8837 | CASP8 and FADD-like apoptosis regulator | Reduction of I-FLICE expression in cholangiocarcinoma cells restored Fas-mediated apoptosis. Therapeutic maneuvers to inhibit expression of I-FLICE may aid in the treatment of cholangiocarcinoma. Our aims were to determine if altered expression of FasR and FasL or changes in expression of FLICE inhibitor (I-FLICE) allow cholangiocarcinoma cells to escape immune surveillance. Human cholangiocarcinoma cell lines express both FasL and FasR and I-FLICE. | Human | VTNR | 7449 | | This study analyzed new cell lineage markers for the differential diagnosis between hepatocellular carcinoma (HCC) and cholangiocarcinoma (ChC), as well as the potential pathways of cell-cell and cell-extracellular matrix interactions of neoplastic liver cells during tumor spread and invasion, by comparing the expression of (VLA) integrins, vitronectin receptor, and neural cell adhesion molecule in normal, inflamed, and neoplastic human liver biopsies. | Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF expression was associated with a significantly higher level of microvessel density and might play a proangiogenic role in cholangiocellular carcinoma EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma | Human | UGT1A | 7361 | UDP glucuronosyltransferase 1 family, polypeptide A complex locus | UGT1A10, a newly discovered UGT1A gene product, is expressed only in biliary and not hepatocellular tissue and is also significantly down-regulated in cholangiocellular carcinoma. | Human | TTR | 7276 | transthyretin | transthyretin down-regulation may have a role in cholangiocarcinoma | Human | HSP90B1 | 7184 | heat shock protein 90kDa beta (Grp94), member 1 | In patients with cholangiocellular carcinoma, the presence of cells expresing Grp94 is related to CD83-positive dendritic cells | Human | TP53 | 7157 | tumor protein p53 | a novel p53-dependent mechanism in the PPARgamma ligand-mediated inhibition of cholangiocarcinoma growth and suggest a potential therapeutic role of PPARgamma ligands in the treatment of human cholangiocarcinoma | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | Tumor necrosis factor alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2. |
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