Genes (44)
Species: human : 44 | |
Human | MAML2 | 84441 | mastermind-like 2 (Drosophila) | A total of 14 cases of clear cell carcinoma of salivary glands were evaluated by immunohistochemical methods using monoclonal antibodies to cytokeratin (K1.1 and K8.12), vimentin, S-100 alpha and beta subunits, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), MAM-3 and MAM-6 antigens and proliferating cell nuclear antigen (PCNA), as well as polyclonal antibodies to lysozyme (Ly), lactoferrin (la) and Alpha-1-antichymotrypsin (alpha 1-Ach). | Human | MUC3B | 57876 | mucin 3B, cell surface associated | The level of MUC3 expression by in-situ hybridization was associated with the nuclear grade in clear cell carcinoma. | Human | SPA17 | 53340 | sperm autoantigenic protein 17 | We identified sperm protein 17 (SP17) as a candidate gene related to the chemoresistance of clear cell carcinoma. Our results strongly suggest that SP17 plays a role in the resistance of clear cell carcinoma to chemotherapy without influencing their ability to proliferate. Sperm protein 17 influences the tissue-specific malignancy of clear cell adenocarcinoma in human epithelial ovarian cancer. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | The immunohistochemical profile of clear cell carcinomas of the urinary tract...is positive for P504S | Human | TACC3 | 10460 | transforming, acidic coiled-coil containing protein 3 | The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. | Human | WFDC2 | 10406 | WAP four-disulfide core domain 2 | Its expression in tumors was restricted to certain histologic subtype: 93% of serous and 100% of endometrioid EOCs expressed HE4, whereas only 50% and 0% of clear cell carcinomas and mucinous tumors, respectively, were positive. | Human | MSLN | 10232 | mesothelin | Because of the strong mesothelin expression in nonmucinous carcinomas of the ovary, but not in a variety of tumors with which these lesions may be confused (eg, clear cell carcinoma of the ovary versus endodermal sinus tumor or renal cell carcinoma, clear cell type; transitional cell carcinoma of the ovary versus TCC of the urinary tract), immunostaining for this marker could be useful in establishing the differential diagnosis. | Human | ABCF2 | 10061 | ATP-binding cassette, sub-family F (GCN20), member 2 | ABCF2 may have a role in progression of clear cell ovarian adenocarcinomas Data suggest that ABCF2 protein may be a candidate marker for clear cell adenocarcinomas of the ovary and the uterine corpus and may be important for the pathogenesis of these diseases | Human | FZD5 | 7855 | frizzled family receptor 5 | Fzd5 membrane staining was detected in 30% of clear cell carcinomas, and there was a strong correlation with nuclear cyclin D1 staining in the samples. | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | although LOH at the VHL gene locus was frequent in ovarian carcinomas, there is no significant correlation between LOH & loss of VHL expression; in 22 clear cell carcinomas, VHL expression showed negative correlation with nuclear expression of HIF-1alpha Down regulation of HIF-1 by VHL protein is associated with tumorigenesis of clear cell carcinoma of the kidney | Human | TP53 | 7157 | tumor protein p53 | p53 mutation was observed in 4 of 13 specimens of endometriosis coexisting with ovarian clear cell carcinoma, whereas no mutations were detected in solitary endometriosis or endometriosis coexisting with ovarian endometrioid carcinoma | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | In contrast, TIMP-2 levels were markedly decreased in malignant tumours compared with normal ovary with the exception of clear cell carcinoma, in which they were significantly elevated. Immunohistochemistry showed that TIMP-2 immunoreactivity was localized predominantly in epithelial cancer cells in clear cell carcinoma, while it was present mainly in stromal cells in the other histological types. In the present study, we assessed the differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma, using specific enzyme-linked immunosorbent assays. TIMP-2 expression is markedly increased in clear cell carcinoma of the ovary, suggesting a role of TIMP-2 in its unique characteristics among ovarian cancers Increased expression of tissue inhibitor of metalloproteinase-2 in clear cell carcinoma of the ovary. Taken together, the present study shows that TIMP-2 expression is markedly increased in clear cell carcinoma of the ovary, suggesting a role of TIMP-2 in its unique characteristics among ovarian cancers. Increased expression of TIMP-2 in clear cell carcinoma was also confirmed by Western blot analysis. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | In the present study, we assessed the differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma, using specific enzyme-linked immunosorbent assays. | Human | KLF10 | 7071 | Kruppel-like factor 10 | TGFBI is up-regulated in clear cell carcinoma by VHL through a Kruppel-like transcriptional factor 10 | Human | HNF1B | 6928 | HNF1 homeobox B | Hepatocyte nuclear factor-1beta is a useful marker to identify these clear cell pancreatic carcinomas Hypomethylation of the HNF-1beta CpG island participates in the HNF-1beta up-regulation in ovarian clear cell carcinoma | Human | TACC1 | 6867 | transforming, acidic coiled-coil containing protein 1 | The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. | Human | SPP1 | 6696 | secreted phosphoprotein 1 | osteopontin expression is elevated in ovarian clear cell carcinoma | Human | SPARC | 6678 | secreted protein, acidic, cysteine-rich (osteonectin) | We found that 6 (100%) of 6 sarcomatoid and 25 (70%) of 36 clear-cell carcinomas had enhanced SPARC transcription compared with that of the corresponding normal kidney tissue. | Human | MAP2K1 | 5604 | mitogen-activated protein kinase kinase 1 | High MEK1 expression was associated with endometrioid and clear cell carcinomas (P=0.049); its loss was found with advancing FIGO stage (P=0.002). | Human | MUC3A | 4584 | mucin 3A, cell surface associated | The level of MUC3 expression by in-situ hybridization was associated with the nuclear grade in clear cell carcinoma. | Human | MUC1 | 4582 | mucin 1, cell surface associated | Cytokeratin 7 and epithelial membrane antigen are essentially negative in yolk sac tumors but are diffusely positive in clear cell carcinomas and endometriod adenocarcinomas making them useful markers for differentiating YSTs from both CCCs and EACs | Human | MST1R | 4486 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | We investigated the expression of Ron, Ki-67 (proliferation index), p53, and bcl-2 (proapoptotic and antiapoptotic proteins, respectively) in 50 renal tumors (19 clear cell carcinomas, 18 oncocytomas, 7 papillary cell carcinomas, 5 chromophobe cell carcinomas, and 1 carcinoma with sarcomatoid areas). | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma | Human | MITF | 4286 | microphthalmia-associated transcription factor | Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in clear cell carcinoma has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1 | Human | EPCAM | 4072 | epithelial cell adhesion molecule | Epithelial cell adhesion molecule has a role in progression of renal cell carcinoma but is absent in clear cell carcinoma |
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