Genes (24)
Species: human : 22 mouse : 2 | |
Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Interestingly, haplo-insufficiency of Ku80 in PARP-1-/- mice promotes the development of hepatocellular adenoma and hepatocellular carcinoma (HCC). | Mouse | IL1RN | 3557 | interleukin 1 receptor antagonist | IL-1ra was immunohistochemically detected in tumor cells in approximately 70% of hepatocellular adenomas and carcinomas, whereas early preneoplastic hepatocytic foci, as well as normal hepatocytes surrounding the lesions, were negative. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Mixed cell foci and hepatocellular adenomas developed within 22-30 weeks and exhibited a remarkable decrease of G6PASE activity, a strong increase of G6PDH, GAPDH, G3PDH and MDH activities as well as extremely high ALKPASE and GGT activities. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Accumulated methylation data were analyzed using various statistical algorithms, including hierarchical clustering, to detect tumor-specific methylation patterns.RESULTS: Cluster analysis revealed that hepatocellular adenoma displays a methylation profile much more similar to that found in normal liver tissue and focal nodular hyperplasia than to that found in hepatocellular carcinoma. | Human | HAMP | 57817 | hepcidin antimicrobial peptide | hepcidin plays a major, causative role in the anemia observed in a subgroup of patients with hepatic adenomas, and may be important in the pathogenesis of the anemia of chronic disease in general | Human | UGT1A3 | 54659 | UDP glucuronosyltransferase 1 family, polypeptide A3 | In liver, UGT1A1, UGT1A3, UGT1A4, and UGT1A9 are expressed, and are all significantly down-regulated in malignant hepatocellular carcinoma and its premalignant precursor, hepatic adenoma, but not in benign focal nodular hyperplasia. | Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | In liver, UGT1A1, UGT1A3, UGT1A4, and UGT1A9 are expressed, and are all significantly down-regulated in malignant hepatocellular carcinoma and its premalignant precursor, hepatic adenoma, but not in benign focal nodular hyperplasia. | Human | MVP | 9961 | major vault protein | In human tissues, the LRP expression levels of dysplastic liver nodules, hepatocellular adenomas, and carcinomas were highly variable, including decreased but also distinctly increased staining intensities. | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | The spatial and temporal patterns of expression of TGF-beta 1, TGF-beta 2, TGF-beta receptor type II messenger RNAs (mRNAs), and TGF-beta 1 proteins in the different hepatic lesions suggests that TGF-beta isoforms may play a role in the pathogenesis of quartz-induced fibrosis, cirrhosis, liver cell adenoma, and carcinoma. | Human | TCF7 | 6932 | transcription factor 7 (T-cell specific, HMG-box) | Bi-allelic inactivation of TCF1 in hepatic adenomas. TCF1: (transcription factor 1) encoding hepatocyte nuclear factor 1alpha (HNF1alpha) is mutated in 50% of liver cell adenomas, a benign tumor closely associated with oral contraceptive use. | Human | HNF1A | 6927 | HNF1 homeobox A | hepatocellular adenomas can be divided into 4 subgroups: one is defined by presence of mutations in TCF1 gene inactivating HNFalpha; 2nd by presence of beta-catenin activating mutations; category without mutations divided based on presence of inflammation HNF1alpha may contribute to endometrial carcinogenesis through complete HNF1alpha inactivation like in liver cell adenoma or by haploinsufficiency like in MSI-H colorectal cancer | Human | SSTR3 | 6753 | somatostatin receptor 3 | All thyroid tumor types regularly expressed sstr1, sstr3, sstr4, and sstr5. sstr2 was expressed in most MTC tumors but was not detected in FA or PC and was irregularly expressed in HCA and HCC. | Human | SAA1 | 6288 | serum amyloid A1 | Since TNF-alpha has been known to induce SAA production in target cells, the present results suggest that the hepatic adenoma produced TNF-alpha, which then caused mainly secondary amyloidosis in the kidney and heart. After the surgical resection of a 300-gram hepatic adenoma, highly elevated c-reactive protein (CRP) levels decreased and the serum amyloid A (SAA) level was completely normalized. | Human | SAA@ | 6287 | serum amyloid A1 cluster | After the surgical resection of a 300-gram hepatic adenoma, highly elevated c-reactive protein (CRP) levels decreased and the serum amyloid A (SAA) level was completely normalized. Since TNF-alpha has been known to induce SAA production in target cells, the present results suggest that the hepatic adenoma produced TNF-alpha, which then caused mainly secondary amyloidosis in the kidney and heart. | Human | RPS6KB1 | 6198 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | EXPERIMENTAL DESIGN: Total and phosphorylated mTOR and S6K protein expression were studied by immunohistochemistry in hepatocellular carcinomas (n = 73), fibrolamellar carcinomas (n = 13), and hepatic adenomas (n = 15). | Human | PTK2 | 5747 | protein tyrosine kinase 2 | Furthermore, FAK protein levels were elevated in preinvasive lesions, such as large (> 2 cm) colonic villous adenomas, whereas noninvasive, yet hypercellular, neoplastic tissues such as parathyroid and hepatocellular adenomas did not overexpress FAK. | Human | PRKCA | 5578 | protein kinase C, alpha | In WY-induced hepatocellular adenomas, PKCalpha was increased, and PKCbeta was further decreased in membrane fractions. These results, taken together with previous studies, indicate that alterations in PKCalpha, beta and delta isoforms, which regulate mitogenesis, could play important roles in perpetuating the high cell proliferative rate in PPC-induced hepatocellular adenomas. | Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | The mRNA profiles for peroxisome proliferator activated receptor (PPAR) alpha and human c-Ha-ras genes were determined by real-time semi-quantitative polymerase chain reaction analysis of hepatocellular adenomas induced by di(2-ethylhexyl)phthalate (DEHP) in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice). | Human | NRCAM | 4897 | neuronal cell adhesion molecule | Distinct cytokeratin 7, cytokeratin 19, & neuronal cell adhesion molecule staining patterns are seen in hepatic adenoma & focal nodular hyperplasia possibly suggest activation of different subsets of hepatic progenitor/stem cell | Human | ITGA1 | 3672 | integrin, alpha 1 | All cases of liver cell adenoma and well-differentiated HCC expressed the same set of integrins as observed in normal liver tissue, i.e., VLA-alpha 1 and VLA-beta 1. | Human | IL6ST | 3572 | interleukin 6 signal transducer (gp130, oncostatin M receptor) | recurrent gain-of-function gp130 mutations in these human hepatocellular adenomas fully explains activation of the acute inflammatory phase observed in tumourous hepatocytes | Human | G6PC | 2538 | glucose-6-phosphatase, catalytic subunit | We report on a 42-year-old female patient with glycogen storage disease type 1a (von Gierke disease, GSD 1a) who developed hepatic adenomas and finally a hepatocellular carcinoma 10 years after renal transplantation. | Human | ENG | 2022 | endoglin | Sinusoids were studied by the application of endothelial cell markers (CD31, CD34, CD105, and ATZ 11) in lesions with localized increased perfusion (liver cell adenoma, focal nodular hyperplasia, and macroregenerative nodule), in chronic congestion, in decreased portovenous inflow (portal vein thrombosis), and in decreased arteriohepatic perfusion (obliterative arteriopathy in chronic allograft rejection). | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | beta-catenin, which participates in the Wnt signaling pathway, might play a more important role in the formation of hepatic adenoma than in that of focal nodular hyperplasia |
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