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Details
Link-It Detail - Disease - Lymphoma, Large-Cell, Anaplastic
Debug Stats
  • ### Total Build Time: 244 ms 87.326 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 362 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 590 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 991 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 7.896 KB
  • CONCEPT_RELATIONSHIPS gt=152 ms Completed: 152 ms rowSize= 15.581 KB
  • CONCEPT_GENES gt=69 ms Completed: 69 ms rowSize= 60.568 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.166 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Lymphoma, Large-Cell, Anaplastic C0206180
Definition (1)
A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001)
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Lymphoma, Non-Hodgkin C0024305
img Lymphoma, T-Cell C0079772
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210706img Lymphoma, Non-Hodgkin C0024305
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242286img Lymphoma, Non-Hodgkin C0024305
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Lymphoma, Non-Hodgkin C0024305
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210707img Lymphoma, T-Cell C0079772
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242287img Lymphoma, T-Cell C0079772
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Lymphoma, T-Cell C0079772
Relationships (79)

Relation Types:
diso_​to_​anat : 22
diso_​to_​chem : 10
diso_​to_​diso : 43
diso_​to_​phen : 2
diso_​to_​phys : 2


Relationships:
none : 29
eo_​disease_​maps_​to_​human_​disease : 1
is_​abnormal_​cell_​of_​disease : 7
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 4
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 21
may_​be_​molecular_​abnormality_​of_​disease : 2
parent_​is_​cdrh : 1
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN95img genetic aspects C0017399
DISO_to_DISO71img Cutaneous tumor C0037286
DISO_to_CHEM64img Protein Tyrosine Kinase C0033681
DISO_to_DISO39img Complication Aspects C1171258
DISO_to_CHEM34img Antigens, CD30 C0054950
DISO_to_DISO33img Cutaneous tumor C0037286
DISO_to_CHEM31img Receptor Protein-Tyrosine Kinases C0206364
DISO_to_DISO31img Breast Neoplasms C1458155
DISO_to_PHEN27img genetic aspects C0017399
DISO_to_CHEM25img Protein Tyrosine Kinase C0033681
DISO_to_DISO25img Hodgkin Disease C0019829
DISO_to_CHEM18img Antigens, CD30 C0054950
DISO_to_CHEM15img Antineoplastic Agents C0003392
DISO_to_DISO14img Lymphomatoid Papulosis C0206182
DISO_to_DISO13img Complication Aspects C1171258
DISO_to_PHYS13img GENE EXPRESSION REG NEOPL C0017268
DISO_to_CHEM12img BIOCHEM TUMOR MARKERS C0041366
DISO_to_CHEM11img Immunoconjugates C0243020
DISO_to_CHEM10img Chimeric Oncogene Proteins C0029014
DISO_to_DISO10img HLH C0024291
DISO_to_DISO10img Hodgkin Disease C0019829
DISO_to_DISO9img Lymphoma, T-Cell C0079772
DISO_to_CHEM8img ACTIVIN RECEPT LIKE KINASES TYPE II C0676594
DISO_to_DISO8img COMPL POSTOP C0032787
DISO_to_DISO8img Diffuse Large B-Cell Lymphoma C0079744
Genes (86)

Species:
human : 86
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanRNF21357674ring finger protein 213
img GENERIF, Score=1000, Pubmed Id: 12112524, UMLKSK CUI: C0206180
HumanLEF151176lymphoid enhancer-binding factor 1
img NCI, Score=801, Pubmed Id: 12707037, UMLKSK CUI: C0206180
HumanPTPN2226191protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
img NCI, Score=801, Pubmed Id: 7611181, UMLKSK CUI: C0206180
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
img NCI, Score=801, Pubmed Id: 15163014, UMLKSK CUI: C0206180
HumanCOPS510987COP9 signalosome subunit 5
img NCI, Score=801, Pubmed Id: 12631617, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12631617, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12631617, UMLKSK CUI: C0206180
HumanMALT110892mucosa associated lymphoid tissue lymphoma translocation gene 1
img NCI, Score=801, Pubmed Id: 14997743, UMLKSK CUI: C0206180
HumanTFG10342TRK-fused gene
img NCI, Score=801, Pubmed Id: 10556217, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 11280613, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 10556217, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 10556217, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12800156, UMLKSK CUI: C0206180
HumanSOCS39021suppressor of cytokine signaling 3
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img GENERIF, Score=1000, Pubmed Id: 15385932, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15385932, UMLKSK CUI: C0206180
HumanNR0B28431nuclear receptor subfamily 0, group B, member 2
img GENERIF, Score=937, Pubmed Id: 16825495, UMLKSK CUI: C0206180
HumanTCL1A8115T-cell leukemia/lymphoma 1A
img NCI, Score=801, Pubmed Id: 10786666, UMLKSK CUI: C0206180
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 12645345, UMLKSK CUI: C0206180
HumanTNFRSF47293tumor necrosis factor receptor superfamily, member 4
img NCI, Score=801, Pubmed Id: 11426518, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12958063, UMLKSK CUI: C0206180
HumanTRAF27186TNF receptor-associated factor 2
img NCI, Score=801, Pubmed Id: 11110706, UMLKSK CUI: C0206180
HumanTRAF17185TNF receptor-associated factor 1
img NCI, Score=801, Pubmed Id: 12754742, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12782762, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12782762, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12754742, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
HumanTPM47171tropomyosin 4
img NCI, Score=801, Pubmed Id: 12800156, UMLKSK CUI: C0206180
HumanTIMP17076TIMP metallopeptidase inhibitor 1
img NCI, Score=801, Pubmed Id: 12174874, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15161657, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12174874, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 12174874, UMLKSK CUI: C0206180
img GENERIF, Score=906, Pubmed Id: 15161657, UMLKSK CUI: C0206180
HumanTIA17072TIA1 cytotoxic granule-associated RNA binding protein
img GENERIF, Score=1000, Pubmed Id: 17493234, UMLKSK CUI: C0206180
HumanTCF76932transcription factor 7 (T-cell specific, HMG-box)
img NCI, Score=801, Pubmed Id: 12707037, UMLKSK CUI: C0206180
HumanSTAT5A6776signal transducer and activator of transcription 5A
img GENERIF, Score=901, Pubmed Id: 17922009, UMLKSK CUI: C0206180
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img NCI, Score=801, Pubmed Id: 14506160, UMLKSK CUI: C0206180
img GENERIF, Score=1000, Pubmed Id: 15895073, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15161657, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 14506160, UMLKSK CUI: C0206180
HumanSPN6693sialophorin
img NCI, Score=801, Pubmed Id: 9160083, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 10091777, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 10786813, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 9160307, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 16019518, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15104308, UMLKSK CUI: C0206180
HumanS100A96280S100 calcium binding protein A9
img NCI, Score=801, Pubmed Id: 8305759, UMLKSK CUI: C0206180
HumanCLIP16249CAP-GLY domain containing linker protein 1
img NCI, Score=801, Pubmed Id: 8161933, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 1450414, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 8222754, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 8161933, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 1450414, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 1450414, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 1450414, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 8161933, UMLKSK CUI: C0206180
HumanREL5966v-rel avian reticuloendotheliosis viral oncogene homolog
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
img NCI, Score=801, Pubmed Id: 15644776, UMLKSK CUI: C0206180
HumanRB15925retinoblastoma 1
img GENERIF, Score=734, Pubmed Id: 15161658, UMLKSK CUI: C0206180
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0206180Lymphoma, Large-Cell, Anaplastic0self