Human | TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | topo IIalpha is a proliferation and also an apoptotic marker in atrophic OLP lesions and it might have a predictive value in oral lichen planus lesions prone to develop malignancy |
Human | TNF | 7124 | tumor necrosis factor | Title:Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus|Association:Not Found|Conclusion:In conclusion, we suggest that genetic polymorphism of the first intron of the promoter gene of IFN-gamma may be an important risk factor to develop oral lesions of LP, whereas an increase in the frequency of -308A TNF-alpha allele may best contribute to the development of additional skin involvement. TNFA homozygous genotypes were significantly more often detected in Oral Lichen Planus patients in OLP (oral lichen planus)-HCV+ve (chronic hepatitis C) patients, the frequency of genotype -308 G/A of the TNF-alpha was decreased, whereas the genotype -308 G/G was increased compared with OLP-HCV-ve |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | production is associated with the inflammatory process of oral lichen planus development |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | Data suggest that in oral lichen planus, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+)T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells |
Human | NTRK1 | 4914 | neurotrophic tyrosine kinase, receptor, type 1 | upregulation and activation in oral lichen planus is one of the pathways that can activate protein kinase B and thereby rescue epithelial cells from untimely cell death |
Human | NGFR | 4804 | nerve growth factor receptor | Basal keratinocytes in oral lichen planus showed no or only weak cytoplasmic staining but in normal oral mucosa there was a clear cell membrane staining |
Human | NGF | 4803 | nerve growth factor (beta polypeptide) | can play a role in the pathology of oral lichen planus |
Human | CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | Data suggest that in oral lichen planus, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+)T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | IL18 polymorphisms may be associated with the pathogenesis of oral lichen planus in this Chinese cohort by upregulation of IL-18 production in vivo |
Human | IL10 | 3586 | interleukin 10 | IL-10 gene polymorphisms were not related to oral lichen planus development |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL-6 homozygous genotypes were significantly more often detected in oral lichen planus patients |
Human | IL1B | 3553 | interleukin 1, beta | IL-1beta polymorphisms were not related to oral lichen planus development |
Human | IFNG | 3458 | interferon, gamma | Title:Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus|Association:Not Found|Conclusion:In conclusion, we suggest that genetic polymorphism of the first intron of the promoter gene of IFN-gamma may be an important risk factor to develop oral lesions of LP, whereas an increase in the frequency of -308A TNF-alpha allele may best contribute to the development of additional skin involvement. IFN-gamma UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP-HCV+ve (oral lichen planus-chronic hepatitis c) patients compared with OLP-HCV-ve that approached the statistical significance Title:Two new polymorphisms in the human interferon gamma (IFN-gamma) promoter.|Association:Not Found|Conclusion:These two polymorphisms have not been detected in the Centre d'Etude du Polymorphisme Humain (CEPH) reference population. |
Human | HLA-DRA | 3122 | | Title:Increased frequency of HLA-DR6 allele in Italian patients with hepatitis C virus-associated oral lichen planus.|Association:Not Found|Conclusion:HCV-related OLP therefore appears to be a distinctive subset particularly associated with the HLA class II allele HLA-DR6. This could partially explain the peculiar geographical heterogeneity of the association between HCV and LP. |
Human | CXCR3 | 2833 | chemokine (C-X-C motif) receptor 3 | Data suggest that in oral lichen planus, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+)T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells |
Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | Data suggest that in oral lichen planus, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+)T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells |
Human | CD44 | 960 | CD44 molecule (Indian blood group) | our findings provided additional evidence that the pathological stress, such as chronic inflammation, altered the expression of CD44 isoforms in oral epithelia and saliva of oral lichen planus patients |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | The low frequency of apoptotic phenomena (caspase-3 and Bax) in epithelial cells of oral lichen planus may create a favourable substrate for malignant transformation |