Genes (95)
Species: human : 92 mouse : 3 | |
Mouse | ERVK4 | 60359 | | Expression of some HERV-K LTRs was found to be high in human and murine germ cell tumors (testicular teratocarcinomas) and low in non-germ-cell tumors. | Mouse | ERVK5 | 60358 | | Expression of some HERV-K LTRs was found to be high in human and murine germ cell tumors (testicular teratocarcinomas) and low in non-germ-cell tumors. | Mouse | ERVK2 | 2087 | | In contrast to most other human endogenous retroviral families, various HERV-K members have open reading frames that code for functional viral proteins which can form noninfectious particles in some germ cell tumors. Expression of some HERV-K LTRs was found to be high in human and murine germ cell tumors (testicular teratocarcinomas) and low in non-germ-cell tumors. The HERV-K viral genes are highly transcribed in germ cell tumors but are transcribed to lower or undetectable levels in most other tissue and tumor types. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | The results from this study suggest that systemic inhibition of GGT would inhibit the nephrotoxic side-effect of cisplatin without interfering with its activity towards germ cell tumours. Therefore, expression of GGT is not necessary for the therapeutic effect of cisplatin in germ cell tumours. The relationship between GGT expression and clinical response to platinum-based chemotherapy was examined in 41 human germ cell tumours. | Human | ERVK7 | 449619 | | Click here to display 10 evidence detail records. | Human | DPPA3 | 359787 | developmental pluripotency associated 3 | Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. The expression patterns of mouse and human DPPA3, in undifferentiated embryonic cells, embryonic germ cells and adult germ cell tumours, together suggest a role for this gene in maintaining cell pluripotentiality. | Human | SNAI3 | 333929 | snail family zinc finger 3 | Human SNAI3 mRNA was expressed in skin melanotic melanoma, lung epidermoid carcinoma, and germ cell tumor. | Human | NANOG | 79923 | Nanog homeobox | Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Nanog possesses an oncogenic potential that may be related to the role it plays in germ cell tumors and to its function in self renewal of ES cells Notably, human STELLAR is located distal to a previously uncharacterized homeobox gene, which is the human homolog of the recently identified murine gene, Nanog, and proximal to the GDF3 locus, whose transcription is restricted to germ cell tumor cells. Conclusions : NANOG is a new marker for testicular CIS and germ cell tumours and the high level of NANOG along with OCT-4 are determinants of the stem cell-like pluripotency of the preinvasive CIS cell. NANOG is a new marker for testicular carcinoma in situ and germ cell tumours Nanog expression also marks the pluripotent germ cells of the nascent gonad at E11.5-E12.5 and is highly expressed in germ cell tumour and teratoma-derived cell lines. | Human | ERVK6 | 64006 | | Click here to display 9 evidence detail records. | Human | ERVK4 | 60359 | | The HERV-K family was expressed in normal tissues such as muscle, skin and brain, as well as in germ cell tumors and other cancerous tissues. The HERV-K viral genes are highly transcribed in germ cell tumors but are transcribed to lower or undetectable levels in most other tissue and tumor types. Selective Differential Display of RNAs containing interspersed repeats: analysis of changes in the transcription of HERV-K LTRs in germ cell tumors. In humans, one ERV family, human endogenous retrovirus-K (HERV-K) is abundantly expressed, and is associated with germ cell tumours, while ERV3 env is expressed in normal human testis. In contrast to most other human endogenous retroviral families, various HERV-K members have open reading frames that code for functional viral proteins which can form noninfectious particles in some germ cell tumors. | Human | ERVK5 | 60358 | | Selective Differential Display of RNAs containing interspersed repeats: analysis of changes in the transcription of HERV-K LTRs in germ cell tumors. In humans, one ERV family, human endogenous retrovirus-K (HERV-K) is abundantly expressed, and is associated with germ cell tumours, while ERV3 env is expressed in normal human testis. In contrast to most other human endogenous retroviral families, various HERV-K members have open reading frames that code for functional viral proteins which can form noninfectious particles in some germ cell tumors. The HERV-K family was expressed in normal tissues such as muscle, skin and brain, as well as in germ cell tumors and other cancerous tissues. The HERV-K viral genes are highly transcribed in germ cell tumors but are transcribed to lower or undetectable levels in most other tissue and tumor types. | Human | KIF27 | 55582 | kinesin family member 27 | KIF7 mRNA was expressed in embryonic stem (ES) cells, melanotic melanoma and Jurkat T cells, while KIF27 mRNA was expressed in testis, pancreatic islet, germ cell tumors and Jurkat T cells. | Human | ST7L | 54879 | suppression of tumorigenicity 7 like | Because allelic loss or rearrangements of human chromosome 1p13 region are reported in breast cancer, germ cell tumors, squamous cell carcinoma of head and neck, non-small cell lung cancer, gastrointestinal stromal/smooth muscle tumors (GIST), meningioma, melanoma, acute megakaryoblastic leukemia (M7), and Kaposi;s sarcoma, ST7R might be a novel tumor suppressor gene on human chromosome 1p13. | Human | DACT1 | 51339 | dishevelled-binding antagonist of beta-catenin 1 | DAPPER1 mRNA was expressed in amnion, fetal brain, eye, heart, adult brain medulla, gastric cancer (signet ring cell features), RER+ colon tumor, acute lymphoblastic leukemia, germ cell tumor, chondrosarcoma, and parathyroid tumor. | Human | DHH | 50846 | desert hedgehog | Chromosomal localization of PTCH2 places it on chromosome 1p33-34, a region deleted in some germ cell tumors, raising the possibility that PTCH2 may be a tumor suppressor in Dhh target cells. | Human | ERVWE1 | 30816 | | Specificity of antibodies directed against Env protein of human endogenous retroviruses in patients with germ cell tumors. We report here that 85% of the patients with germ cell tumors (GCTs) produce antibodies directed against Env protein of human endogenous retroviruses. | Human | RACGAP1 | 29127 | Rac GTPase activating protein 1 | A protein of the predicted size 58 kDa, which we call MgcRacGAP, was detected in human testis as well as in germ cell tumor extracts by immunoblotting with antibodies specific to recombinant protein. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | Melanomas, squamous cell carcinomas, basal cell carcinomas, soft tissue tumors (including epithelioid sarcomas and synovial sarcoma), thymomas, and germ cell tumors were negative for AMACR. | Human | SRGAP2 | 23380 | SLIT-ROBO Rho GTPase activating protein 2 | FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. | Human | CHEK2 | 11200 | checkpoint kinase 2 | As DNA breaks occur commonly during gametogenesis, and p53 is wild-type and overexpressed in testicular cancer, we examined abundance and localisation of the Chk2 protein during normal development of human testes, and at various stages of germ-cell tumour (GCT) pathogenesis. Our findings suggest that deregulation of CHEK2 and/or PPP2R2A is of pathogenetic importance in at least a subset of germ cell tumors. deregulation of CHEK2 and/or PPP2R2A is of pathogenetic importance in at least a subset of germ cell tumors | Human | PNMA2 | 10687 | paraneoplastic Ma antigen 2 | Eighteen patients had antibodies limited to Ma2: they developed limbic, hypothalamic, and brainstem encephalitis, and 78% had germ-cell tumors of the testis. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. | Human | MSLN | 10232 | mesothelin | All germ cell tumors, with the exception of teratomas, were consistently negative for mesothelin. | Human | SRGAP3 | 9901 | SLIT-ROBO Rho GTPase activating protein 3 | FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. | Human | GDF3 | 9573 | growth differentiation factor 3 | Notably, human STELLAR is located distal to a previously uncharacterized homeobox gene, which is the human homolog of the recently identified murine gene, Nanog, and proximal to the GDF3 locus, whose transcription is restricted to germ cell tumor cells. | Human | XAGE1D | 9503 | X antigen family, member 1D | XAGE-1 and XAGE-2 are expressed in Ewing;s sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor. |
|