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Genes (14)
Species: human : 14 | |
Human | IL23R | 149233 | interleukin 23 receptor | IL-23R gene is associated with autoimmune thyroid diseases only in a specific ethnic group | Human | ZFAT | 57623 | zinc finger and AT hook domain containing | Polymorphism, Single Nucleotide in ZFAT is associated with autoimmune thyroid disease | Human | FOXP3 | 50943 | forkhead box P3 | results suggest that polymorphisms of the FOXP3 gene may play a role in the genetic susceptibility to autoimmune thyroid diseases in Caucasians, perhaps by altering FOXP3 function and/or expression | Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | R620W polymorphism of PTPN22 is not major risk allele for SLE susceptibility in Caucasians from northern America, the UK, or Finland, but it appears to be risk factor for concurrent autoimmune diseases of autoimmune thyroid disease and SLE data suggest that the codon 620 polymorphism of the PTPN22 gene does not have a causal role for autoimmune thyroid diseases in the Japanese | Human | TSHR | 7253 | thyroid stimulating hormone receptor | Title:|Association:Not Found|Conclusion:Not Found | Human | TPO | 7173 | thyroid peroxidase | human TPO has a discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases | Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | Autoimmune thyroid disease induced by thyroglobulin and lipopolysaccharide is inhibited by soluble TNF receptor type I | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | the +869T/C polymorphism in the TGF-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease | Human | TG | 7038 | thyroglobulin | analysis of family data did not show linkage of the thyroglobulin gene with autoimmune thyroid diseases nor did analysis of case-control data show association of Tgms2 or SNPs with Graves' disease Title:Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease.|Association:Y|Conclusion:Although these findings may represent a random chance event, in view of previous reports of linkage and association of this gene region to AITD, this may be an example of a rare causal variant of a complex disease. At this stage, we cannot exclude the Tg region as harboring a susceptibility locus for autoimmune thyroid disease No differences in allele frequencies were observed between autoimmune thyroid disease cases and controls for D8S284 variant We have identified the thyroglobulin gene in females with autoimmune thyroid diseases | Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | SDF1 gene variant is present in patients with type 1 diabetes mellitus and autoimmune thyroid disease | Human | SLC26A4 | 5172 | solute carrier family 26 (anion exchanger), member 4 | Title:PDS is a new susceptibility gene to autoimmune thyroid diseases: association and linkage study.|Association:Not Found|Conclusion:Not Found work suggests that the pendrin gene should be considered a new susceptibility gene to autoimmune thyroid diseases | Human | IL2RA | 3559 | interleukin 2 receptor, alpha | euthyroid female relatives of autoimmune thyroid disease patients had a reduced expression of CD25 on CD4+ T cells | Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | Title:Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.|Association:Y|Conclusion:These results confirm and expand on our previous study suggesting that alleles of the TSHR and CTLA-4 genes, or genes near them contribute to AITD susceptibility and set the stage for future studies of interactions between these genes and AITD. Polymorphisms occur in the pathogenic mechanism of autoimmune thyroid diseases (REVIEW) the CTLA4 gene is involved in the susceptibility for Graves' disease and autoimmune thyroid disease in the Japanese Results suggest that the linkage of the CTLA-4 A49G single nucleotide polymorphism to autoimmune thyroid disease is most likely secondary to linkage disequilibrium Title:Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease.|Association:Y|Conclusion:An association was detected between the CTLA-4 gene polymorphism and younger-onset type 1 diabetes with AITD. The G variant was suggested to be genetically linked to AITD-associated type 1 diabetes of younger onset in this apanese population. The defect in these patients presumably lies in a T-cell-mediated autoimmune mechanism. Title:Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese.|Association:Y|Conclusion:These results suggested that the CTLA4 gene is involved in the susceptibility for GD and AITD in the Japanese. Association of CTLA4 with type 1 diabetes in previous studies may have been secondary to autoimmune thyroid disease | Human | FASLG | 356 | Fas ligand (TNF superfamily, member 6) | Fas ligand appear to be differentially expressed on peripheral lymphocytes in the two opposite phenotypes of autoimmune thyroid disease |
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