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Genes (21)
Species: human : 21 | |
Human | TP63 | 8626 | tumor protein p63 | We performed a systematic evaluation of p63 expression in cytological and histological preparations of 10 fibroadenoma specimens. | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family. | Human | SCG2 | 7857 | secretogranin II | We examined CgA, SgI and SgII mRNA expression by reverse transcription-polymerase chain reaction in rat mammary adenocarcinoma and fibroadenoma which had arisen spontaneously in aging Fischer-344 rats. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | The TIMP-1 levels released into the culture media by carcinoma tissues were significantly lower than those by fibroadenoma tissues, although there were no significant differences in the levels of MMP-1, MMP-2, MMP-9 and TIMP-2. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | The TIMP-1 levels released into the culture media by carcinoma tissues were significantly lower than those by fibroadenoma tissues, although there were no significant differences in the levels of MMP-1, MMP-2, MMP-9 and TIMP-2. | Human | SRD5A2 | 6716 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. | Human | SNCG | 6623 | synuclein, gamma (breast cancer-specific protein 1) | To evaluate the clinical relevance of SNCG expression in breast cancer progression and its correlation with clinical parameters, we analyzed SNCG expression in 79 clinical breast specimens from primary breast cancer, hyperplasia, and fibroadenoma patients by reverse transcription-PCR. | Human | RHEB | 6009 | Ras homolog enriched in brain | RHEB could be used cytopathologically to distinguish fibroadenoma from malignant breast carcinomas as a secondary diagnostic tool | Human | PZP | 5858 | pregnancy-zone protein | Thus, PZP levels in breast cancer patients did not differ from those of fibroadenoma patients or healthy women. | Human | PTEN | 5728 | phosphatase and tensin homolog | | Human | PPP2CA | 5515 | protein phosphatase 2, catalytic subunit, alpha isozyme | The expression of the three catalytic subunits of protein phosphatase (PP) type 1, PP1 alpha, PP1 gamma 1 and PP1 delta, as well as the one catalytic subunit of PP type 2, PP2AC, were examined in ten cases of mammary dysplasia, ten cases of fibroadenoma and 12 cases of invasive ductal carcinoma, using immunohistochemical analysis. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | METHODS: The expressions of VEGF and nm23-H1 gene were detected using immunohistochemical method (SP) in the breast cancer tissues of 48 young and 30 postmenopausal women with breast cancer and in breast fibroadenoma tissues of 10 patients for analysis of the association of the expressions with the patients; clinical and pathological characteristics, with also observation of the 5-year survival rate in each patient group. METHODS: The expressions of VEGF and nm23-H(1) gene were detected using immunohistochemical method (SP) in the breast cancer tissues of 48 young and 30 postmenopausal women with breast cancer and in breast fibroadenoma tissues of 10 patients for analysis of the association of the expressions with the patients; clinical and pathological characteristics, with also observation of the 5-year survival rate in each patient group. RESULTS: The rates of axillary lymph node metastasis was higher in the young women than in the postmenopausal women, who also had significantly different rates of VEGF and nm23-H(1) expressions in the breast cancer tissues (P<0.01, P<0.01 and P<0.05, respectively); between the two breast cancer groups and breast fibroadenoma group, the expressions were also different (P<0.01). | Human | KRT16 | 3868 | keratin 16 | In samples from normal tissue and a fibroadenoma, the antibody recognized a major Mr 48,000 component, a size appropriate for K16. | Human | INHBA | 3624 | inhibin, beta A | review article of gene expression of inhibin beta A in normal breast carcinoma, fibroadenoma, and normal mammary tissue | Human | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | RESULTS: HIF-1alpha expression in nuclei was found in DCIS and IDC, but not in normal or fibroadenoma cells. | Human | GJA1 | 2697 | gap junction protein, alpha 1, 43kDa | Phosphorylated Cx43, is up-regulated in hyperplasias and dysplasias and fibroadenoma and is strongly up-regulated in invasive carcinomas | Human | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | Western blot analysis demonstrated the presence of FGF-1 protein in all of the samples from breast cancer, but not benign tumors such as mastopathy and fibroadenoma. The extent and intensity of immunoreactive FGF-1 polypeptides in cancer cells was statistically much greater than those of cells from fibroadenoma or mastopathy. | Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | HER-2 polymorphism, especially in a homozygous form might play some role in the etiology of breast fibroadenoma formation | Human | EIF4EBP1 | 1978 | eukaryotic translation initiation factor 4E binding protein 1 | Thus, we examined 165 invasive breast cancers with specific antibodies for the phosphorylation of Akt, mTOR, and 4E-BP1 by immunohistochemistry and compared them with normal breast epithelium, fibroadenoma, intraductal hyperplasia, and ductal carcinoma in situ. | Human | CTAG1B | 1485 | cancer/testis antigen 1B | In 1 case of fibroadenoma, NY-ESO-1 mRNA was 8% of the testicular level, and protein was detected by Western blot analysis. | Human | BMPR1A | 657 | bone morphogenetic protein receptor, type IA | |
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