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Details
Link-It Detail - Disease - Liver Failure, Acute
Debug Stats
  • ### Total Build Time: 275 ms 37.937 KB
  • CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 624 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 549 bytes
  • CONCEPT_CHILDREN gt=6 ms Completed: 6 ms rowSize= 562 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=11 ms Completed: 11 ms rowSize= 1.500 KB
  • CONCEPT_RELATIONSHIPS gt=197 ms Completed: 197 ms rowSize= 14.056 KB
  • CONCEPT_GENES gt=32 ms Completed: 32 ms rowSize= 18.991 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Liver Failure, Acute C0162557
Definition (1)
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Liver Failure C0085605
Children (1)
img Massive Hepatic Necrosis C0001364
Ancestral Roots
RootRoot Plus OneDepthParent
img Digestive System Diseases C0012242img Liver Diseases C00238955img Liver Failure C0085605
Relationships (105)

Relation Types:
diso_​to_​anat : 14
diso_​to_​chem : 24
diso_​to_​diso : 57
diso_​to_​phen : 3
diso_​to_​phys : 7


Relationships:
none : 97
is_​associated_​anatomic_​site_​of : 3
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 1
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO322img chemically induced C0007994
DISO_to_DISO200img chemically induced C0007994
DISO_to_DISO181img Complication Aspects C1171258
DISO_to_ANAT134img In Blood C0005768
DISO_to_ANAT95img Liver C0023884
DISO_to_CHEM90img Acetaminophen C0000970
DISO_to_DISO87img Complication Aspects C1171258
DISO_to_ANAT81img In Blood C0005768
DISO_to_DISO70img Hepatic Encephalopathy C0019151
DISO_to_DISO62img Disease, Drug-Induced Liver C0860207
DISO_to_CHEM57img Analgesics, Non Narcotic C0242937
DISO_to_ANAT52img Hepatocyte C0227525
DISO_to_DISO52img End Stage Liver Disease C0745744
DISO_to_ANAT51img Hepatocyte C0227525
DISO_to_ANAT44img Liver C0023884
DISO_to_DISO44img Hepatic Encephalopathy C0019151
DISO_to_DISO41img Hepatitis B C0019163
DISO_to_CHEM39img Acetaminophen C0000970
DISO_to_PHEN39img genetic aspects C0017399
DISO_to_DISO35img Chronic Hepatitis B C0524909
DISO_to_DISO32img Brain Edema C1527311
DISO_to_DISO31img Liver Cirrhosis C0023890
DISO_to_DISO25img Intracranial Hypertension C0151740
DISO_to_ANAT24img Brain C0006104
DISO_to_DISO24img Hepatitis, Viral, Human C0019195
Genes (18)

Species:
human : 18
SpeciesGeneGeneIdGene NameEvidence
HumanGFM185476G elongation factor, mitochondrial 1
img OMIM, Score=1000, UMLKSK CUI: C0162557
HumanRGN9104regucalcin
img GENERIF, Score=1000, Pubmed Id: 18507831, UMLKSK CUI: C0162557
HumanVIP7432vasoactive intestinal peptide
img GENERIF, Score=1000, Pubmed Id: 11884208, UMLKSK CUI: C0162557
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 15968724, UMLKSK CUI: C0162557
HumanS100A126283S100 calcium binding protein A12
img GENERIF, Score=1000, Pubmed Id: 11884208, UMLKSK CUI: C0162557
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=884, Pubmed Id: 19017995, UMLKSK CUI: C0162557
HumanPOLG5428polymerase (DNA directed), gamma
img GENERIF, Score=1000, Pubmed Id: 17923349, UMLKSK CUI: C0162557
HumanNPY4852neuropeptide Y
img GENERIF, Score=1000, Pubmed Id: 11884208, UMLKSK CUI: C0162557
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
img GENERIF, Score=1000, Pubmed Id: 12399227, UMLKSK CUI: C0162557
HumanNOS24843nitric oxide synthase 2, inducible
img GENERIF, Score=1000, Pubmed Id: 12399227, UMLKSK CUI: C0162557
HumanIL183606interleukin 18 (interferon-gamma-inducing factor)
img GENERIF, Score=1000, Pubmed Id: 12679613, UMLKSK CUI: C0162557
HumanHMOX13162heme oxygenase (decycling) 1
img GENERIF, Score=756, Pubmed Id: 15547665, UMLKSK CUI: C0162557
HumanHADH3033hydroxyacyl-CoA dehydrogenase
img OMIM, Score=1000, UMLKSK CUI: C0162557
HumanGC2638group-specific component (vitamin D binding protein)
img GENERIF, Score=1000, Pubmed Id: 17763397, UMLKSK CUI: C0162557
HumanCD40LG959CD40 ligand
img GENERIF, Score=1000, Pubmed Id: 18652769, UMLKSK CUI: C0162557
HumanFAS355Fas cell surface death receptor
img GENERIF, Score=1000, Pubmed Id: 12679613, UMLKSK CUI: C0162557
HumanALAS1211aminolevulinate, delta-, synthase 1
img GENERIF, Score=756, Pubmed Id: 15547665, UMLKSK CUI: C0162557
HumanACADM34acyl-CoA dehydrogenase, C-4 to C-12 straight chain
img GENERIF, Score=1000, Pubmed Id: 17186412, UMLKSK CUI: C0162557
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0162557Liver Failure, Acute0self