| Debug Stats | ### Total Build Time: 14 ms 34.015 KB CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 364 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 223 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytesCONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 32.101 KBCONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.167 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
|
Genes (23)
Species:
human : 23 | |
| Human | LOC100507436 | 100507436 | | Title:[Studies on the polymorphism of MICA gene in four Chinese populations]|Association:Not Found|Conclusion:Alleles of MICA gene exon 5 are conservative in all populations studied so far. The results suggest that genetically BMT might be an independent ethnic population. Title:[Polymorphism of short tandem repeat of exon 5 of MHC class-I chain related gene A and association with nasopharyngeal carcinoma in a southern Chinese population]|Association:Not Found|Conclusion:MICA-STR polymorphism is associated with NPC, and MICA*A9 is a genetic susceptibility marker of male individuals for NPC in a southern Chinese population. | | Human | NAT6 | 24142 | N-acetyltransferase 6 (GCN5-related) | newly identified polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase and the proline-rich domains; analysis suggests no likely association between nasopharyngeal cancer and the FUS2 gene polymorphism | | Human | TNF | 7124 | tumor necrosis factor | Title:Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma.|Association:Not Found|Conclusion:The P2/P2 genotype of the HSP70-2 gene may be a marker of increased risk of NPC in Tunisians. | | Human | PIGR | 5284 | polymeric immunoglobulin receptor | Title:[Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]|Association:Not Found|Conclusion:SNP C8880T of pIgR is related with NPC susceptibility; pIgR gene may be associated to risk of NPC development. Title:Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer.|Association:Not Found|Conclusion:We present genetic evidence leading to hypothesize a possibility of PIGR to function as the EBV nasopharyngeal epithelium receptor via IgA-EBV complex transcytosis failure. The PIGR1739C-->T is a missense mutation changing alanine to valine near endoproteolytic cleavage site. This variant could alter the efficiency of PIGR to release IgA-EBV complex and consequently increase the susceptibility of populations in endemic areas to develop NPC. | | Human | PFN1 | 5216 | profilin 1 | adenosine triphosphate synthase alpha chain was up-regulated, whereas annexin II, annexin V, beta(2)-tubulin, and profilin 1 were down-regulated in nasopharyngeal cancer cell lines | | Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Title:Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type.|Association:Not Found|Conclusion:This study was performed to improve the definition of the pathogenetic factors implicated in UCNT by addressing the correlation between cytokine polymorphisms and clinical parameters. This is the first study investigating the possible role of the IL-18 and IL-10 polymorphisms in the development and outcome of UCNT. In our genetic analysis there is no evidence for involvement of IL-10 promoter polymorphisms alone in the genetic predisposition to this tumor. On the other hand, IL18 genetic variants may represent a genetic risk factor for tumor aggressiveness. | | Human | HSPA1B | 3304 | heat shock 70kDa protein 1B | Title:Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma.|Association:Not Found|Conclusion:The P2/P2 genotype of the HSP70-2 gene may be a marker of increased risk of NPC in Tunisians. | | Human | HLA-E | 3133 | | Title:HLA-E polymorphism in patients with nasopharyngeal carcinoma|Association:Y|Conclusion:This observation suggests a possible role for HLA-E in NPC development, possibly via natural killer cell or cytotoxic lymphocyte function. | | Human | HLA-DRB1 | 3123 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Not Found|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HLA-DQB1 | 3119 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Not Found|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HLA-DQA1 | 3117 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Not Found|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HLA-DPB1 | 3115 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Not Found|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HLA-B | 3106 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Not Found|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HLA-A | 3105 | | Title:Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan|Association:Y|Conclusion:The restriction of the association of HLA-A2 with NPC to HLA-A*0207 probably explains previously observed associations of HLA-A2 with NPC among Chinese but not Caucasians. The extended haplotypes associated with NPC might, in part, explain the higher rates of NPC in this ethnic group. | | Human | HGF | 3082 | hepatocyte growth factor (hepapoietin A; scatter factor) | A direct role for HGF in the invasive phenotype and motility of nasopharyngeal cancer cells was shown | | Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | Title:[Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China]|Association:Y|Conclusion:In high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied. | | Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Title:[Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China]|Association:Y|Conclusion:In high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied. | | Human | NQO1 | 1728 | NAD(P)H dehydrogenase, quinone 1 | Title:[Quinone oxidoreductase gene polymorphism and genetic susceptibility to nasopharyngeal carcinoma]|Association:Y|Conclusion:The cDNA 609 T allele of NQO1 gene is very likely to be associated with the genetic susceptibility to nasopharyngeal carcinoma. | | Human | CYP2E1 | 1571 | cytochrome P450, family 2, subfamily E, polypeptide 1 | expression of human cytochrome P450 2E1 gene in embryonic nasopharynx, nasopharyngeal cancer cell lines and tissue | | Human | CYP2A13 | 1553 | cytochrome P450, family 2, subfamily A, polypeptide 13 | Title:Genetic polymorphisms of the human CYP2A13 gene:identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.|Association:Not Found|Conclusion:The frequencies of the Arg257Cys allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. Title:Single nucleotide polymorphisms of the human cyp2a13 gene: evidence for a null allele.|Association:Not Found|Conclusion:The frequency of the Arg25Gln mutation in Asian newborns (9.6%) was very similar to that found in the Chinese population (10.9%). On the other hand, the Arg101Stop mutation was not detected in 136 newborn samples examined (23 white, 21 black, 19 Hispanic, and 73 Asian), suggesting that this mutation may be unique for the Chinese patient population. Haplotype analysis indicated that the Arg25Gln and Arg257Cys mutations are parts of a common haplotype. However, an additional haplotype that consists of the 25Gln but not the 257Cys allele was also identified. | | Human | CYP2A6 | 1548 | cytochrome P450, family 2, subfamily A, polypeptide 6 | Title:|Association:Not Found|Conclusion:Not Found | | Human | CR2 | 1380 | complement component (3d/Epstein Barr virus) receptor 2 | Title:Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer.|Association:Not Found|Conclusion:We present genetic evidence leading to hypothesize a possibility of PIGR to function as the EBV nasopharyngeal epithelium receptor via IgA-EBV complex transcytosis failure. The PIGR1739C-->T is a missense mutation changing alanine to valine near endoproteolytic cleavage site. This variant could alter the efficiency of PIGR to release IgA-EBV complex and consequently increase the susceptibility of populations in endemic areas to develop NPC. | | Human | ANXA5 | 308 | annexin A5 | adenosine triphosphate synthase alpha chain was up-regulated, whereas annexin II, annexin V, beta(2)-tubulin, and profilin 1 were down-regulated in nasopharyngeal cancer cell lines |
|
