Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | RESULTS: There was a strong inverse correlation between the levels of nm23 mRNA expression and nm23 antigen expression and the development of metastases of all seven human uveal melanomas and both murine skin melanomas transplanted intracamerally. |
Human | CMM4 | 474388 | Melanoma, cutaneous malignant, 4 | |
Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | Because of the primary clinical relevance of cancer-testis antigens; expression in neoplastic tissues, 68 unrelated or sequential metastatic lesions from 56 patients were used to characterize the molecular mechanisms regulating the presence and levels of expression of different cancer-testis antigens of the MAGE family (i.e., MAGE2, 3 and 4) in cutaneous melanoma. Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma. |
Human | RASEF | 158158 | RAS and EF-hand domain containing | Expression of RASEF, a known gene in this region, was examined in tumor tissue from 10 sporadic CMM lesions and was found to be decreased in 70% of these tumors compared with RASEF expression in a human reference RNA pool from 10 different cell types and in 10 breast tumors. |
Human | NCRNA00032 | 158035 | | Integrative analysis of functional genomics data was applied to determine the role of C9orf14 in CMM development. |
Human | MIB2 | 142678 | mindbomb E3 ubiquitin protein ligase 2 | Notably, 23 of 25 benign nevi expressed skeletrophin in cytoplasm, but 18 of 38 cases of primary skin melanoma appeared to lack skeletrophin expression. |
Human | MAGED4B | 81557 | melanoma antigen family D, 4B | It has previously been reported that MAGE-1, -2, -3 and -4 genes are expressed in human cancers including cutaneous melanoma. |
Human | RMI1 | 80010 | RecQ mediated genome instability 1 | Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma |
Human | TRPM8 | 79054 | transient receptor potential cation channel, subfamily M, member 8 | results reveal that a functional TRPM8 protein is expressed in human melanoma cells to involve the mechanism underlying tumor progression via the Ca(2+) handling pathway, providing us with a novel target of drug development for malignant melanoma |
Human | SPANXC | 64663 | SPANX family, member C | genetic variability of SPANX-B & SPANX-C in a sample of Sicilian male population including patients with cutaneous melanoma; statistical significant difference for a particular class of SPANX-C gene was found comparing patients with melanoma & controls |
Human | PRDM16 | 63976 | PR domain containing 16 | Positive reactivity to HMB-45 and MEL-1 was as follows: oral melanomas, 13/16 and 9/16, respectively; cutaneous melanomas, 8/8 and 8/8; melanoma of the digit, 1/1 and 1/1; all pigmented melanomas, 16/18 and 14/18; all amelanotic tumours, 6/7 and 4/7. |
Human | FXYD5 | 53827 | FXYD domain containing ion transport regulator 5 | Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma. Over expression of dysadherin is associated with cutaneous malignant melanoma METHODS: Expression of both dysadherin and E-cadherin was investigated immunohistochemically in 115 patients with cutaneous malignant melanoma to determine the correlation between the 2 molecules and their associations with both patient survival and the clinicopathologic features of the tumors. CONCLUSIONS: Thus, increased expression of dysadherin was a significant indicator of poor prognosis in patients with cutaneous malignant melanoma. |
Human | DKK2 | 27123 | dickkopf WNT signaling pathway inhibitor 2 | loss of DKK expression plays a role in development or progression of malignant melanoma |
Human | DKK3 | 27122 | dickkopf WNT signaling pathway inhibitor 3 | loss of DKK expression plays a role in development or progression of malignant melanoma |
Human | BBC3 | 27113 | BCL2 binding component 3 | PUMA expression is significantly reduced in human cutaneous melanomas. |
Human | ABCA12 | 26154 | ATP-binding cassette, sub-family A (ABC1), member 12 | study identified two novel ABCA12 mutations in two unrelated non-bullous congenital ichthyosiform erythroderma patients; both patients presented with multiple skin malignancies including malignant melanoma |
Human | BRMS1 | 25855 | breast cancer metastasis suppressor 1 | Thus, BRMS1 functions as a metastasis suppressor in more than one tumor type (i.e., breast carcinoma and cutaneous melanoma) by modifying several metastasis-associated phenotypes. BRMS1 functions as a metastasis suppressor in more than one tumor type(i.e., breast carcinoma and cutaneous melanoma)by modifying several metastasis-associated phenotypes |
Human | DKK1 | 22943 | dickkopf WNT signaling pathway inhibitor 1 | loss of DKK expression plays a role in development or progression of malignant melanoma |
Human | CHEK2 | 11200 | checkpoint kinase 2 | Rarity of germline 1100delC mutation in CHK2 in patients with malignant melanoma of the skin. |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | The RASSF1A gene is turned off in a significant number of melanomas and that CpG promoter region hypermethylation may play a role in the transcriptional inactivation of the RASSF1A gene in malignant melanoma |
Human | PSIP1 | 11168 | PC4 and SFRS1 interacting protein 1 | OBJECTIVE: To determine the immunophenotypic differences between uveal and cutaneous melanomas, employing standard melanoma markers as well as p75 neurotrophin receptor (p75NTR) and microphthalmia transcription factor (MITF). |
Human | IL24 | 11009 | interleukin 24 | study demonstrate that expression of the MDA-7 tumor suppressor can negatively regulate iNOS expression in malignant melanoma cell lines |
Human | DBF4 | 10926 | DBF4 homolog (S. cerevisiae) | There is the differential regulation of a novel gene, namely ASK/Dbf4, in melanoma and suggest that up-regulation of ASK/Dbf4 is a novel molecular determinant with prognostic relevance that confers a proliferative advantage in cutaneous melanoma |
Human | IGF2BP3 | 10643 | insulin-like growth factor 2 mRNA binding protein 3 | IMP-3 appears to be involved in the progression of malignant melanoma |
Human | HOXB13 | 10481 | homeobox B13 | HOXB13 is downregulated by methylation and functions as a tumor suppressor in malignant melanoma |